VU533
Based on 1 publication(s) in Google Scholar
APE-PLD (VU533) activator is a potent NAPE-PLD activator with an EC50 value of 0.30 µM. NAPE-PLD activator (VU533) can enhance NAPE-PLD activity and increase efferocytosis by macrophages. NAPE-PLD activator (VU533) can be used for cardiometabolic diseases research.
For research use only. We do not sell to patients.
- Purity: 99.84%
- CAS No.: 923417-09-8
- Formula: C21H22FN3O3S2
- Molecular Weight:447.55
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Metabolism/Protease Compound Library
HY-L012
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Lipid Metabolism Compound Library
HY-L091
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Metabolic Enzyme Compound Library
HY-L146
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Macrophage Related Compound Library
HY-L174
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
Publications Citing Use of MedChemExpress (MCE) VU533
MoreAll Phospholipase Isoforms
More
Biological Activity
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PLD1 0.3 μM (EC50) |
NAPE-PLD activator (VU533) (0.1-30 μM, 24 h) has no cytotoxicity when tested at 30 μM in either RAW264.7 or HepG2 cells[1].
NAPE-PLD activator (0.1-30 μM, 24 h) increases Nape-pld activity in a concentration-dependent manner in RAW264.7 cells and HepG2 cells[1].
NAPE-PLD activator (10 μM, 6 h) enhances efferocytosis in bone-marrow derived macrophages (BMDM) [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RAW264.7, HepG2
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Concentration:0.1-30 μM
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Incubation Time:24 h
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Result:Showed no cytotoxicity when tested at 30 μM in either RAW264.7 or HepG2 cells.
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Cell Line:BMDM
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Concentration:10 μM
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Incubation Time:6 h
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Result:Enhanced efferocytosis compared to vehicle treated BMDM at 10μM.
Chemical Information
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CAS No. 923417-09-8
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Appearance Solid
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Molecular Weight 447.55
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Formula C21H22FN3O3S2
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Color White to off-white
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SMILES
CC1=C2SC(NC(C3CCN(S(=O)(C4=CC=C(C=C4)F)=O)CC3)=O)=NC2=C(C)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
Solvent & Solubility
DMSO : 125 mg/mL (279.30 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2344 mL | 11.1719 mL | 22.3439 mL | 55.8597 mL |
| 5 mM | 0.4469 mL | 2.2344 mL | 4.4688 mL | 11.1719 mL | |
| 10 mM | 0.2234 mL | 1.1172 mL | 2.2344 mL | 5.5860 mL | |
| 15 mM | 0.1490 mL | 0.7448 mL | 1.4896 mL | 3.7240 mL | |
| 20 mM | 0.1117 mL | 0.5586 mL | 1.1172 mL | 2.7930 mL | |
| 25 mM | 0.0894 mL | 0.4469 mL | 0.8938 mL | 2.2344 mL | |
| 30 mM | 0.0745 mL | 0.3724 mL | 0.7448 mL | 1.8620 mL | |
| 40 mM | 0.0559 mL | 0.2793 mL | 0.5586 mL | 1.3965 mL | |
| 50 mM | 0.0447 mL | 0.2234 mL | 0.4469 mL | 1.1172 mL | |
| 60 mM | 0.0372 mL | 0.1862 mL | 0.3724 mL | 0.9310 mL | |
| 80 mM | 0.0279 mL | 0.1396 mL | 0.2793 mL | 0.6982 mL | |
| 100 mM | 0.0223 mL | 0.1117 mL | 0.2234 mL | 0.5586 mL |
VU533 Related Classifications
HY-155774 Related Classifications
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