1. Metabolic Enzyme/Protease
  2. Phospholipase
  3. ARN19874

ARN19874 is a selective, reversible uncompetitive N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) activity inhibitor with an IC50 of ~34 μM.

For research use only. We do not sell to patients.

ARN19874 Chemical Structure

ARN19874 Chemical Structure

CAS No. : 2190502-57-7

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 709 In-stock
Solution
10 mM * 1 mL in DMSO USD 709 In-stock
Solid
5 mg USD 645 In-stock
10 mg   Get quote  
50 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

ARN19874 is a selective, reversible uncompetitive N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) activity inhibitor with an IC50 of ~34 μM[1].

IC50 & Target

IC50: ~34 μM (NAPE-PLD)[1]

Molecular Weight

394.40

Formula

C19H14N4O4S

CAS No.
Appearance

Solid

Color

Off-white to pink

SMILES

O=S(C1=CC2=C(NC(NC2=O)=O)C=C1)(NC3=CC=C(C4=CC=NC=C4)C=C3)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (316.94 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5355 mL 12.6775 mL 25.3550 mL
5 mM 0.5071 mL 2.5355 mL 5.0710 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5355 mL 12.6775 mL 25.3550 mL 63.3874 mL
5 mM 0.5071 mL 2.5355 mL 5.0710 mL 12.6775 mL
10 mM 0.2535 mL 1.2677 mL 2.5355 mL 6.3387 mL
15 mM 0.1690 mL 0.8452 mL 1.6903 mL 4.2258 mL
20 mM 0.1268 mL 0.6339 mL 1.2677 mL 3.1694 mL
25 mM 0.1014 mL 0.5071 mL 1.0142 mL 2.5355 mL
30 mM 0.0845 mL 0.4226 mL 0.8452 mL 2.1129 mL
40 mM 0.0634 mL 0.3169 mL 0.6339 mL 1.5847 mL
50 mM 0.0507 mL 0.2535 mL 0.5071 mL 1.2677 mL
60 mM 0.0423 mL 0.2113 mL 0.4226 mL 1.0565 mL
80 mM 0.0317 mL 0.1585 mL 0.3169 mL 0.7923 mL
100 mM 0.0254 mL 0.1268 mL 0.2535 mL 0.6339 mL
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ARN19874 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
ARN19874
Cat. No.:
HY-118994
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