Dlgap1 - DLG associated protein 1 Gene

Also Known as Gkap; Sapap1; mKIAA4162; 9630002F18; GKAP/SAPAP; GKPA/SAPAP; D17Bwg0511e; 4933422O14Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 224997

Summary

Predicted to enable molecular adaptor activity and protein domain specific binding activity. Predicted to be a structural constituent of postsynaptic density. Predicted to be involved in several processes, including aggresome assembly; regulation of postsynaptic neurotransmitter receptor activity; and regulation of proteasomal protein catabolic process. Predicted to act upstream of or within chemical synaptic transmission. Located in postsynaptic density. Is expressed in hippocampus. Orthologous to human DLGAP1 (DLG associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Dlgap1 Products (9)

mRNA Protein Name
NM_001128180.1 NP_001121652.1 disks large-associated protein 1 isoform 3
NM_001128181.1 NP_001121653.1 disks large-associated protein 1 isoform 4
NM_001347411.1 NP_001334340.1 disks large-associated protein 1 isoform 5
NM_001347412.1 NP_001334341.1 disks large-associated protein 1 isoform 6
NM_001347413.1 NP_001334342.1 disks large-associated protein 1 isoform 7
NM_001347414.1 NP_001334343.1 disks large-associated protein 1 isoform 8
NM_001360665.1 NP_001347594.1 disks large-associated protein 1 isoform 6
NM_027712.3 NP_081988.3 disks large-associated protein 1 isoform 2
NM_177639.6 NP_808307.2 disks large-associated protein 1 isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
28671696 MGI
Cellular Component GO Annotation Evidence References Source
located in postsynaptic density IDA
IDA: Inferred from direct assay
17114649 MGI
located in postsynaptic density IMP
IMP: Inferred from mutant phenotype
21558424 MGI
located in synapse IDA
IDA: Inferred from direct assay
15024750 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

disks large-associated protein 1

  • DAP-1 beta

  • PSD-95/SAP90-binding protein 1

  • SAP90/PSD-95 associated protein 1

  • discs, large homolog-associated protein 1

  • guanylate kinase-associated protein

Dlgap1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Dlgap1 Q9D415 Homer1 Mus musculus Q9Z2Y3
Anti Bait CoIP
28671696
Intra
Dlgap1 Q9D415 Grin2a Mus musculus P35436
Anti Bait CoIP
28671696
Intra
Dlgap1 Q9D415 Syngap1 Mus musculus F6SEU4
Anti Bait CoIP
28671696
Intra
Dlgap1 Q9D415 Cnksr2 Mus musculus Q80YA9
Anti Bait CoIP
28671696
Intra
Dlgap1 Q9D415 Shank3 Mus musculus Q4ACU6
Anti Bait CoIP
28671696
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03801 DLGAP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dlgap1 NCBI NCBI:9229