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Shank3 - SH3 and multiple ankyrin repeat domains 3 Gene

Also Known as Spank-2; proSAP2

Species: Mus musculus

Gene Type: protein coding

Gene ID: 58234

Summary

Enables ionotropic glutamate receptor binding activity; protein C-terminus binding activity; and scaffold protein binding activity. A structural constituent of postsynaptic density. Involved in several processes, including learning or memory; modulation of chemical synaptic transmission; and postsynapse organization. Acts upstream of or within several processes, including MAPK cascade; negative regulation of actin filament bundle assembly; and regulation of AMPA glutamate receptor clustering. Located in glutamatergic synapse and neuron spine. Is extrinsic component of cytoplasmic side of plasma membrane. Is expressed in brain and cerebral cortex. Used to study Phelan-McDermid syndrome; autism spectrum disorder; and schizophrenia. Human ortholog(s) of this gene implicated in Phelan-McDermid syndrome and schizophrenia 15. Orthologous to human SHANK3 (SH3 and multiple ankyrin repeat domains 3). [provided by Alliance of Genome Resources, Apr 2022]

Shank3 Products (1)

mRNA	Protein	Name
NM_021423.4	NP_067398.3	SH3 and multiple ankyrin repeat domains protein 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ionotropic glutamate receptor binding	IPI IPI: Inferred from physical interaction	15207857	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15569713	MGI
enables scaffold protein binding	IPI IPI: Inferred from physical interaction	16606358	MGI
enables structural constituent of postsynaptic density	IDA IDA: Inferred from direct assay	27161151	MGI
enables structural constituent of postsynaptic density	IEP IEP: Inferred from expression pattern	27161151	MGI
enables structural constituent of postsynaptic density	IMP IMP: Inferred from mutant phenotype	27161151	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in AMPA glutamate receptor clustering	IMP IMP: Inferred from mutant phenotype	21558424	MGI
acts upstream of or within MAPK cascade	IGI IGI: Inferred from genetic interaction	15569713	MGI
involved in NMDA glutamate receptor clustering	IMP IMP: Inferred from mutant phenotype	21558424	MGI
involved in associative learning	IMP IMP: Inferred from mutant phenotype	26158416	MGI
involved in brain morphogenesis	IMP IMP: Inferred from mutant phenotype	21423165	MGI
acts upstream of or within dendritic spine morphogenesis	IMP IMP: Inferred from mutant phenotype	21558424	MGI
involved in dendritic spine morphogenesis	IMP IMP: Inferred from mutant phenotype	21167025	MGI
acts upstream of or within embryonic epithelial tube formation	IGI IGI: Inferred from genetic interaction	15569713	MGI
involved in exploration behavior	IMP IMP: Inferred from mutant phenotype	21558424	MGI
involved in gene expression	IMP IMP: Inferred from mutant phenotype	30116174	MGI
involved in glial cell proliferation	IMP IMP: Inferred from mutant phenotype	27785461	MGI
involved in guanylate kinase-associated protein clustering	IMP IMP: Inferred from mutant phenotype	21558424	MGI
involved in learning	IMP IMP: Inferred from mutant phenotype	21558424	MGI
acts upstream of or within learning or memory	IMP IMP: Inferred from mutant phenotype	21558424	MGI
involved in locomotion	IMP IMP: Inferred from mutant phenotype	21558424	MGI
acts upstream of or within locomotory behavior	IMP IMP: Inferred from mutant phenotype	21558424	MGI
involved in locomotory exploration behavior	IMP IMP: Inferred from mutant phenotype	21423165	MGI
involved in long-term synaptic depression	IMP IMP: Inferred from mutant phenotype	21795692	MGI
involved in long-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	21558424	MGI
involved in memory	IMP IMP: Inferred from mutant phenotype	21558424	MGI
involved in modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	27161151	MGI
involved in modulation of chemical synaptic transmission	IEP IEP: Inferred from expression pattern	27161151	MGI
involved in modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	27161151	MGI
acts upstream of or within negative regulation of actin filament bundle assembly	IDA IDA: Inferred from direct assay	19208628	MGI
involved in negative regulation of cell volume	IMP IMP: Inferred from mutant phenotype	21423165	MGI
involved in neural precursor cell proliferation	IMP IMP: Inferred from mutant phenotype	27785461	MGI
involved in neuromuscular process controlling balance	IMP IMP: Inferred from mutant phenotype	21558424	MGI
involved in positive regulation of dendritic spine development	IMP IMP: Inferred from mutant phenotype	21795692	MGI
involved in positive regulation of excitatory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	21167025	MGI
involved in positive regulation of glutamate receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	21795692	MGI
involved in positive regulation of long-term neuronal synaptic plasticity	IMP IMP: Inferred from mutant phenotype	21167025	MGI
involved in positive regulation of long-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	21167025	MGI
involved in positive regulation of synapse structural plasticity	IMP IMP: Inferred from mutant phenotype	21167025	MGI
involved in positive regulation of synaptic transmission, glutamatergic	IMP IMP: Inferred from mutant phenotype	21167025	MGI
involved in postsynaptic density assembly	IMP IMP: Inferred from mutant phenotype	21423165	MGI
acts upstream of or within regulation of AMPA glutamate receptor clustering	IMP IMP: Inferred from mutant phenotype	21558424	MGI
involved in regulation of behavioral fear response	IMP IMP: Inferred from mutant phenotype	21423165	MGI
involved in regulation of dendritic spine morphogenesis	IMP IMP: Inferred from mutant phenotype	21795692	MGI
involved in regulation of grooming behavior	IMP IMP: Inferred from mutant phenotype	21423165	MGI
involved in regulation of long-term synaptic depression	IMP IMP: Inferred from mutant phenotype	21795692	MGI
involved in regulation of long-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	21558424	MGI
acts upstream of or within regulation of synaptic plasticity	IMP IMP: Inferred from mutant phenotype	21558424	MGI
involved in response to interleukin-17	IMP IMP: Inferred from mutant phenotype	31853066	MGI
acts upstream of or within social behavior	IMP IMP: Inferred from mutant phenotype	21558424	MGI
involved in social behavior	IMP IMP: Inferred from mutant phenotype	21167025	MGI
involved in striatal medium spiny neuron differentiation	IMP IMP: Inferred from mutant phenotype	21423165	MGI
involved in synapse assembly	IMP IMP: Inferred from mutant phenotype	21423165	MGI
acts upstream of or within vocalization behavior	IMP IMP: Inferred from mutant phenotype	21558424	MGI
involved in vocalization behavior	IMP IMP: Inferred from mutant phenotype	21167025	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	27161151	MGI
is active in glutamatergic synapse	IEP IEP: Inferred from expression pattern	27161151	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	27161151	MGI
located in neuron projection	IDA IDA: Inferred from direct assay	21795692	MGI
located in neuron spine	IDA IDA: Inferred from direct assay	16606358	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	16606358	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
SH3 and multiple ankyrin repeat domains protein 3	SH3/ankyrin domain gene 3 proline-rich synapse-associated protein 2

Shank3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Shank3	Q4ACU6	Homer1	Mus musculus	Q9Z2Y3	Anti Tag CoIP	28469556
Intra	Shank3	Q4ACU6	Homer1	Mus musculus	Q9Z2Y3	Pull Down	29111324
Intra	Shank3	Q4ACU6	Homer1	Mus musculus	Q9Z2Y3	Anti Bait CoIP	28671696
Intra	Shank3	Q4ACU6	Homer1	Mus musculus	Q9Z2Y3	Pull Down	28701918
Intra	Shank3	Q4ACU6	Dlg2	Mus musculus	Q91XM9	Pull Down	29111324
Intra	Shank3	Q4ACU6	Dlg2	Mus musculus	Q91XM9	Anti Bait CoIP	28671696
Intra	Shank3	Q4ACU6	Dlg2	Mus musculus	Q91XM9	Anti Tag CoIP	28469556
Intra	Shank3	Q4ACU6	Dlgap1	Mus musculus	Q9D415	Anti Bait CoIP	28671696
Intra	Shank3	Q4ACU6	Baiap2	Mus musculus	Q8BKX1	Anti Tag CoIP	28469556
Intra	Shank3	Q4ACU6	Baiap2	Mus musculus	Q8BKX1	Pull Down	29111324
Intra	Shank3	Q4ACU6	Baiap2	Mus musculus	Q8BKX1	Anti Bait CoIP	28671696
Intra	Shank3	Q4ACU6	Cyfip2	Mus musculus	Q5SQX6	Anti Bait CoIP	28671696

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12852	SHANK3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-163345	5-HT7R antagonist 2	Antagonist	/	Unkown
HY-P10106	TAT-PAK18 inhibitory peptide	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Shank3	NCBI	NCBI:85358