Homer1 - homer scaffolding protein 1 Gene

Also Known as SYN47; Ves-1; vesl-1; homer-1; PSD-Zip45

Species: Mus musculus

Gene Type: protein coding
Gene ID: 26556

Summary

Predicted to enable several functions, including scaffold protein binding activity; transmembrane transporter binding activity; and type 5 metabotropic glutamate receptor binding activity. Predicted to be a structural constituent of postsynapse. Involved in regulation of ion transport and regulation of postsynaptic neurotransmitter receptor activity. Acts upstream of or within several processes, including behavioral response to cocaine; chemical homeostasis within a tissue; and skeletal muscle fiber development. Located in several cellular components, including apical part of cell; myofibril; and postsynaptic density. Is active in glutamatergic synapse and postsynaptic cytosol. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human HOMER1 (homer scaffold protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Homer1 Products (5)

mRNA Protein Name
NM_001284189.2 NP_001271118.1 homer protein homolog 1 isoform b
NM_001347598.1 NP_001334527.1 homer protein homolog 1 isoform M
NM_011982.4 NP_036112.1 homer protein homolog 1 isoform S
NM_147176.4 NP_671705.2 homer protein homolog 1 isoform L
NM_152134.3 NP_687036.1 homer protein homolog 1 isoform d

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12176012 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within behavioral response to cocaine IMP
IMP: Inferred from mutant phenotype
15294147 MGI
acts upstream of or within positive regulation of calcium ion transport IMP
IMP: Inferred from mutant phenotype
18268005 MGI
involved in regulation of calcium ion import IMP
IMP: Inferred from mutant phenotype
14505576 MGI
involved in regulation of cation channel activity IMP
IMP: Inferred from mutant phenotype
14505576 MGI
involved in regulation of postsynaptic neurotransmitter receptor activity IDA
IDA: Inferred from direct assay
11418862 MGI
involved in regulation of postsynaptic neurotransmitter receptor activity IMP
IMP: Inferred from mutant phenotype
11418862 MGI
involved in regulation of store-operated calcium entry IMP
IMP: Inferred from mutant phenotype
14505576 MGI
acts upstream of or within skeletal muscle contraction IMP
IMP: Inferred from mutant phenotype
18268005 MGI
acts upstream of or within skeletal muscle fiber development IMP
IMP: Inferred from mutant phenotype
18268005 MGI
Cellular Component GO Annotation Evidence References Source
located in Z disc IDA
IDA: Inferred from direct assay
18268005 MGI
located in apical part of cell IDA
IDA: Inferred from direct assay
12860966 MGI
located in axon IDA
IDA: Inferred from direct assay
23791195 MGI
located in costamere IDA
IDA: Inferred from direct assay
18268005 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
12176012 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
11418862 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
11418862 MGI
located in membrane IDA
IDA: Inferred from direct assay
15579147 MGI
located in neuron projection IDA
IDA: Inferred from direct assay
21795692 MGI
located in neuron projection IMP
IMP: Inferred from mutant phenotype
21664258 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
12176012 MGI
located in postsynapse IDA
IDA: Inferred from direct assay
24554721 MGI
is active in postsynaptic cytosol IDA
IDA: Inferred from direct assay
24530450 MGI
is active in postsynaptic density IDA
IDA: Inferred from direct assay
21664258 MGI
located in postsynaptic density IDA
IDA: Inferred from direct assay
21558424 MGI
located in postsynaptic density IMP
IMP: Inferred from mutant phenotype
21558424 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

homer protein homolog 1

  • VASP/Ena-related gene up-regulated during seizure and LTP 1

  • homer homolog 1

  • homer, neuronal immediate early gene, 1

  • immediate early gene protein Homer1A

Homer1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Homer1 Q9Z2Y3 Dlgap1 Mus musculus Q9D415
Anti Bait CoIP
28671696
Intra
Homer1 Q9Z2Y3 Shank3 Mus musculus Q4ACU6
Anti Bait CoIP
28671696
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-100001 SKF-96365 (hydrochloride) 99.93% Unkown
HY-125942 SKF-96365 99.97% Unkown
HY-RS06283 HOMER1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21139 Homer1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27657 Homer1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Homer1 NCBI NCBI:9456