FGF11 - fibroblast growth factor 11 Gene

Also Known as FHF3; FHF-3; FGF-11

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2256

About FGF11

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,438,298-7,444,937 (from NCBI)

This gene has 6 transcripts (splice variants), 1 gene allele, 277 orthologues and 21 paralogues. Broad expression in adrenal (RPKM 9.9), skin (RPKM 7.0) and 14 other tissues.

Summary

The protein encoded by this gene is a member of the Fibroblast Growth Factor (FGF) family. FGF Family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this gene has not yet been determined. The expression pattern of the mouse homolog implies a role in nervous system development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

FGF11 Products (2)

mRNA Protein Name
NM_001303460.2 NP_001290389.1 fibroblast growth factor 11 isoform 2
NM_004112.4 NP_004103.1 fibroblast growth factor 11 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FGF11 Protein Structure

FGF

FGF: Fibroblast growth factor (72 - 197)

  • 0
  • 100
  • 200
  • 225 a.a.
Protein Preferred Names Protein Names

fibroblast growth factor 11

  • fibroblast growth factor homologous factor 3

FGF11 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
FGF11 Q92914 HMBOX1 Homo sapiens Q6NT76
Y2H Prey Pooling
32296183
Intra
FGF11 Q92914 HMBOX1 Homo sapiens Q6NT76
Y2H Array
32296183
Intra
FGF11 Q92914 THAP1 Homo sapiens Q9NVV9
Validated Y2H
32296183
Intra
FGF11 Q92914 THAP1 Homo sapiens Q9NVV9
Y2H Array
32296183
Intra
FGF11 Q92914 THAP1 Homo sapiens Q9NVV9
Y2H Prey Pooling
32296183
Intra
FGF11 Q92914 STAC3 Homo sapiens Q96MF2
Y2H Prey Pooling
32296183
Intra
FGF11 Q92914 STAC3 Homo sapiens Q96MF2
Validated Y2H
32296183
Intra
FGF11 Q92914 STAC3 Homo sapiens Q96MF2
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant FGF11 Proteins

Cat. No. Product Name Accession Purity
HY-P700054AF Animal-Free FGF-11 isoform 1 Protein, Human (His) Q92914 (M1-P225) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P700055AF Animal-Free FGF-11 isoform 2 Protein, Human (His) NP_001290389.1 (M1-P166) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Spinocerebellar Ataxia 27

  • Spinocerebellar Ataxia Type 27

  • SCA27

  • Cerebellar Ataxia Autosomal Dominant Fgf14-Related

  • Vestibulocerebellar Disorder With Predominant Ocular Signs

  • Cerebellar Ataxia, Autosomal Dominant, Fgf14-Related

  • Nystagmus 4, Congenital, Autosomal Dominant, Formerly

  • Nys4, Formerly

  • Ataxia, Spinocerebellar, Type 27
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04888 FGF11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174710 Human FGF11 mRNA / Unkown
HY-RS20926 Fgf11 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27443 Fgf11 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta FGF11 VGNC VGNC:104600
Bos taurus FGF11 VGNC VGNC:28971
Canis familiaris FGF11 VGNC VGNC:40840
Rattus norvegicus FGF11 RGD RGD:620162
Mus musculus FGF11 MGD MGI:109167
Felis catus FGF11 VGNC VGNC:62245
Others FGF11 NCBI