Kdm2a - lysine (K)-specific demethylase 2A Gene

Also Known as Fbl7; Cxxc8; Fbl11; Jhdm1; Fbxl11; Gm4560; Jhdm1a; lalina; 100043628; 5530401A10Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 225876

Summary

Enables unmethylated CpG binding activity. Acts upstream of or within several processes, including chordate embryonic development; heart looping; and positive regulation of macromolecule metabolic process. Located in chromatin. Is expressed in embryo; forebrain; and limb. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human KDM2A (lysine demethylase 2A). [provided by Alliance of Genome Resources, Apr 2022]

Kdm2a Products (1)

mRNA Protein Name
NM_001001984.2 NP_001001984.2 lysine-specific demethylase 2A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables unmethylated CpG binding IDA
IDA: Inferred from direct assay
20417597 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within heart looping IMP
IMP: Inferred from mutant phenotype
25463925 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
25463925 MGI
acts upstream of or within multicellular organism growth IMP
IMP: Inferred from mutant phenotype
25463925 MGI
acts upstream of or within negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
25463925 MGI
acts upstream of or within negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
25463925 MGI
acts upstream of or within neural tube closure IMP
IMP: Inferred from mutant phenotype
25463925 MGI
acts upstream of or within neuroepithelial cell differentiation IMP
IMP: Inferred from mutant phenotype
25463925 MGI
acts upstream of or within neuron differentiation IMP
IMP: Inferred from mutant phenotype
25463925 MGI
acts upstream of or within positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
25463925 MGI
involved in transcription initiation-coupled chromatin remodeling IMP
IMP: Inferred from mutant phenotype
32584788 MGI
Cellular Component GO Annotation Evidence References Source
located in chromatin IDA
IDA: Inferred from direct assay
20417597 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

lysine-specific demethylase 2A

  • F-box and leucine-rich repeat protein 11

  • F-box protein containing leucine repeats

  • F-box/LRR-repeat protein 11

  • [Histone-H3]-lysine-36 demethylase 1A

  • jmjC domain-containing histone demethylation protein 1A

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12304 IOX1 Inhibitor 99.89% Unkown
HY-13643 Daminozide Inhibitor 99.79% Unkown
HY-107573 KDM2/7-IN-1 Inhibitor 99.9% Unkown
HY-108706 KDM2A/7A-IN-1 Inhibitor 99.94% Unkown
HY-RS07209 KDM2A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-183618 DW-229 Degrader / Unkown
HY-RS16796 Kdm2a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17111 Kdm3a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23237 Kdm2a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kdm2a NCBI NCBI:22992