Xpc - xeroderma pigmentosum, complementation group C Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22591

Summary

Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and damaged DNA binding activity. Involved in UV-damage excision repair. Acts upstream of or within mitotic intra-S DNA damage checkpoint signaling; pyrimidine dimer repair by nucleotide-excision repair; and response to UV. Located in nucleus and site of DNA damage. Used to study lung Cancer and xeroderma pigmentosum group C. Human ortholog(s) of this gene implicated in pancreatic cancer; serous cystadenocarcinoma; xeroderma pigmentosum; and xeroderma pigmentosum group C. Orthologous to human XPC (XPC complex subunit, DNA damage recognition and repair factor). [provided by Alliance of Genome Resources, Apr 2022]

Xpc Products (1)

mRNA Protein Name
NM_009531.2 NP_033557.2 DNA repair protein complementing XP-C cells homolog

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA polymerase II-specific DNA-binding transcription factor binding IDA
IDA: Inferred from direct assay
25901318 MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
25901318 MGI
enables damaged DNA binding IDA
IDA: Inferred from direct assay
22431748 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
22431748 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within DNA damage response IMP
IMP: Inferred from mutant phenotype
15010313 MGI
acts upstream of or within DNA repair IMP
IMP: Inferred from mutant phenotype
12555660 MGI
involved in UV-damage excision repair IDA
IDA: Inferred from direct assay
22431748 MGI
acts upstream of or within mitotic intra-S DNA damage checkpoint signaling IGI
IGI: Inferred from genetic interaction
15533840 MGI
acts upstream of or within nucleotide-excision repair IDA
IDA: Inferred from direct assay
12815074 MGI
involved in nucleotide-excision repair IDA
IDA: Inferred from direct assay
22431748 MGI
acts upstream of or within nucleotide-excision repair IMP
IMP: Inferred from mutant phenotype
9067411 MGI
acts upstream of or within pyrimidine dimer repair by nucleotide-excision repair IMP
IMP: Inferred from mutant phenotype
17049932 MGI
acts upstream of or within response to UV-B IMP
IMP: Inferred from mutant phenotype
15010313 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
12815074 MGI
is active in site of DNA damage IDA
IDA: Inferred from direct assay
22431748 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DNA repair protein complementing XP-C cells homolog

  • p125

  • xeroderma pigmentosum group C-complementing protein homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-157786 XPC-5462 Inhibitor 99.65% Unkown
HY-157784 XPC-7724 Inhibitor 99.46% Unkown
HY-128772 XPC-6444 Inhibitor 98.93 Unkown
HY-RS15885 XPC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20245 Xpc Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26753 Xpc Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Xpc NCBI NCBI:7508