FGL1 - fibrinogen like 1 Gene

Also Known as HPS; HFREP1; HP-041; LFIRE1; LFIRE-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2267

About FGL1

Cytogenetic location: 8p22 Genomic coordinates (GRCh38): 8:17,864,389-17,895,538 (from NCBI)

This gene has 11 transcripts (splice variants), 126 orthologues and 25 paralogues. Restricted expression toward liver (RPKM 275.4).

Summary

Fibrinogen-like 1 is a member of the fibrinogen family. This protein is homologous to the carboxy terminus of the fibrinogen beta- and gamma- subunits which contains the four conserved cysteines of fibrinogens and fibrinogen related proteins. However, this protein lacks the platelet-binding site, cross-linking region and a thrombin-sensitive site which are necessary for fibrin clot formation. This protein may play a role in the development of hepatocellular carcinomas. Four alternatively spliced transcript variants encoding the same protein exist for this gene. [provided by RefSeq, Jul 2008]

FGL1 Products (4)

mRNA Protein Name
NM_004467.4 NP_004458.3 fibrinogen-like protein 1 precursor
NM_147203.2 NP_671736.2 fibrinogen-like protein 1 precursor
NM_201552.1 NP_963846.1 fibrinogen-like protein 1 precursor
NM_201553.1 NP_963847.1 fibrinogen-like protein 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
30580966 GOA
Biological Process GO Annotation Evidence References Source
involved in hepatocyte proliferation IDA
IDA: Inferred from direct assay
19880967 GOA
Cellular Component GO Annotation Evidence References Source
located in extracellular region IDA
IDA: Inferred from direct assay
30580966 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FGL1 Protein Structure

Fibrinogen_C

Fibrinogen_C: Fibrinogen beta and gamma chains, C-terminal globular domain (80 - 304)

  • 0
  • 100
  • 200
  • 312 a.a.
Protein Preferred Names Protein Names

fibrinogen-like protein 1

  • hepassocin

Recombinant FGL1 Proteins

Cat. No. Product Name Accession Purity
HY-P70737 FGL1 Protein, Human (HEK293, His, solution) Q08830 (L23-I312) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P70740 FGL1 Protein, Human (HEK293, mFc) Q08830 (L23-I312) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72369 FGL1 Protein, Human (Biotinylated, HEK293, Avi-His) Q08830 (L23-I312) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P78128 FGL1 Protein, Human (Biotinylated, 242a.a, HEK293, His-Avi) Q08830 (D64-N305) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P78443 FGL1 protein, Human (242a.a, HEK293, His-Avi) Q08830 (D64-N305) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P78875 FGL1 Protein, Human (Biotinylated, HEK293, Fc-Avi) Q08830 (L23-I312) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P78876 FGL1 Protein, Human (Biotinylated, 249a.a, HEK293, Fc-Avi) Q08830 (D64-I312) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P701077 FGL1 Protein, Human (242a.a, HEK293, hFc) Q08830 (D64-N305) ≥ 95%, as determined by reducing SDS-PAGE.

FGL1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P84514 FGL1 Antibody (YA4211) IHC-P, ICC/IF, FC, ELISA Human
HY-P84514A FGL1 Antibody (YA4211)(PBS only) IHC-P, ICC/IF, FC, ELISA Human

Related Diseases

Diseases Alias
Hepatocellular Carcinoma

  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Carcinoma, Hepatocellular

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99156 Relatlimab 98.00% Phase 4

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-164308 SA-15-P Inhibitor 99.62% Unkown
HY-RS04927 FGL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17106 Fgl1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23550 Fgl1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Bioactive MoleculesInhibitory Antibodies (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990243 Anti-Mouse FGL-1 Antibody (177R4) Ligand 96.31% Unkown
HY-P992352 ES005 / Unkown
HY-P992461 SHR-1802 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus FGL1 VGNC VGNC:78497
Rattus norvegicus FGL1 RGD RGD:620169
Mus musculus FGL1 MGD MGI:102795
Bos taurus FGL1 VGNC VGNC:28992
Macaca mulatta FGL1 VGNC VGNC:84000
Canis familiaris FGL1 VGNC VGNC:40864
Others FGL1 NCBI