Sesn2 - sestrin 2 Gene

Also Known as HI95; Ses2; SEST2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 230784

Summary

Enables GDP-dissociation inhibitor activity. Involved in several processes, including DNA damage response, signal transduction by p53 class mediator; negative regulation of TORC1 signaling; and negative regulation of translation in response to endoplasmic reticulum stress. Acts upstream of or within several processes, including positive regulation of lipophagy; protein kinase B signaling; and regulation of cAMP-dependent protein kinase activity. Part of TORC2 complex and nucleotide-activated protein kinase complex. Is expressed in central nervous system and retina. Orthologous to human SESN2 (sestrin 2). [provided by Alliance of Genome Resources, Apr 2022]

Sesn2 Products (1)

mRNA Protein Name
NM_144907.1 NP_659156.1 sestrin-2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GDP-dissociation inhibitor activity IDA
IDA: Inferred from direct assay
25259925 MGI
enables PH domain binding IPI
IPI: Inferred from physical interaction
31915252 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
18692468 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within D-glucose import IMP
IMP: Inferred from mutant phenotype
22958918 MGI
involved in DNA damage response, signal transduction by p53 class mediator IMP
IMP: Inferred from mutant phenotype
18692468 MGI
acts upstream of or within activation of protein kinase activity IDA
IDA: Inferred from direct assay
31915252 MGI
involved in cellular response to amino acid stimulus IMP
IMP: Inferred from mutant phenotype
25259925 MGI
involved in cellular response to oxidative stress IMP
IMP: Inferred from mutant phenotype
23274085 MGI
acts upstream of or within fatty acid beta-oxidation IGI
IGI: Inferred from genetic interaction
22958918 MGI
acts upstream of or within glucose homeostasis IGI
IGI: Inferred from genetic interaction
22958918 MGI
acts upstream of or within mitochondrial DNA metabolic process IMP
IMP: Inferred from mutant phenotype
22958918 MGI
acts upstream of or within mitochondrion organization IMP
IMP: Inferred from mutant phenotype
22958918 MGI
involved in negative regulation of TORC1 signaling IMP
IMP: Inferred from mutant phenotype
24947615 MGI
involved in negative regulation of cell growth IDA
IDA: Inferred from direct assay
20203043 MGI
involved in negative regulation of translation in response to endoplasmic reticulum stress IMP
IMP: Inferred from mutant phenotype
24947615 MGI
acts upstream of or within positive regulation of lipophagy IMP
IMP: Inferred from mutant phenotype
22958918 MGI
acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
22958918 MGI
acts upstream of or within regulation of cAMP-dependent protein kinase activity IMP
IMP: Inferred from mutant phenotype
22958918 MGI
acts upstream of or within regulation of gluconeogenesis IMP
IMP: Inferred from mutant phenotype
22958918 MGI
acts upstream of or within regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
22958918 MGI
acts upstream of or within response to glucose IGI
IGI: Inferred from genetic interaction
22958918 MGI
acts upstream of or within response to glucose IMP
IMP: Inferred from mutant phenotype
22958918 MGI
acts upstream of or within response to insulin IGI
IGI: Inferred from genetic interaction
22958918 MGI
acts upstream of or within response to insulin IMP
IMP: Inferred from mutant phenotype
22958918 MGI
acts upstream of or within triglyceride homeostasis IMP
IMP: Inferred from mutant phenotype
22958918 MGI
Cellular Component GO Annotation Evidence References Source
part of TORC2 complex IDA
IDA: Inferred from direct assay
25377878 MGI
part of nucleotide-activated protein kinase complex IDA
IDA: Inferred from direct assay
18692468 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sestrin-2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N2593 Isorhapontigenin 99.82% Unkown
HY-RS12735 SESN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20488 Sesn2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26996 Sesn2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sesn2 NCBI NCBI:83667