Nppa - natriuretic peptide type A Gene

Also Known as ANP; Anf; CDD; Pnd

Species: Mus musculus

Gene Type: protein coding
Gene ID: 230899

Summary

This gene encodes members of the natriuretic family of peptides that play an important role in the control of extracellular fluid volume and electrolyte homeostasis. The encoded protein precursor undergoes proteolytic processing to generate multiple functional peptides. Mice lacking the encoded peptides exhibit salt-sensitive hypertension. The transgenic overexpression of the encoded peptides in mice decreases arterial blood pressure without inducing diuresis and natriuresis. This gene is located adjacent to another member of the natriuretic family of peptides on chromosome 4. [provided by RefSeq, Oct 2015]

Nppa Products (1)

mRNA Protein Name
NM_008725.3 NP_032751.1 natriuretic peptides A preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
33245046 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cardiac muscle hypertrophy in response to stress IDA
IDA: Inferred from direct assay
24137001 MGI
acts upstream of cardiac muscle hypertrophy in response to stress IMP
IMP: Inferred from mutant phenotype
26536903 MGI
acts upstream of or within cardiac muscle hypertrophy in response to stress IMP
IMP: Inferred from mutant phenotype
14985074 MGI
involved in female pregnancy IMP
IMP: Inferred from mutant phenotype
22437503 MGI
acts upstream of or within negative regulation of blood pressure IMP
IMP: Inferred from mutant phenotype
23542788 MGI
involved in negative regulation of blood pressure IMP
IMP: Inferred from mutant phenotype
23981445 MGI
involved in regulation of blood pressure IMP
IMP: Inferred from mutant phenotype
22437503 MGI
acts upstream of or within sodium ion export across plasma membrane IMP
IMP: Inferred from mutant phenotype
23542788 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12738802 MGI
located in extracellular space IDA
IDA: Inferred from direct assay
15452027 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

natriuretic peptides A

  • atrial natriuretic factor prohormone

  • atrial natriuretic peptide prohormone

  • atriopeptigen

  • cardiodilatin

  • natriuretic peptide precursor type A

  • preproANF

  • preproANP

  • preproCDD-ANF

  • prepronatriodilatin

  • proANF

  • proANP

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99047 Simtuzumab Inhibitor ≥99.0% Phase 2

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09494 NPPA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-180583 GRK5-IN-5 Inhibitor / Unkown
HY-RS19624 Nppa Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26119 Nppa Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nppa NCBI NCBI:4878