Tnfrsf14 - tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) Gene

Also Known as TR2; Atar; HveA; Hvem; Tnfrs14

Species: Mus musculus

Gene Type: protein coding
Gene ID: 230979

Summary

Predicted to enable cytokine binding activity and ubiquitin protein Ligase binding activity. Acts upstream of or within several processes, including defense response to bacterium; negative regulation of alpha-beta T cell proliferation; and positive regulation of macromolecule metabolic process. Located in external side of plasma membrane. Is expressed in liver lobe. Orthologous to human TNFRSF14 (TNF Receptor Superfamily member 14). [provided by Alliance of Genome Resources, Apr 2022]

Tnfrsf14 Products (1)

mRNA Protein Name
NM_178931.2 NP_849262.1 tumor necrosis factor receptor superfamily member 14 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15568026 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of CD4-positive, alpha-beta T cell proliferation IDA
IDA: Inferred from direct assay
15568026 MGI
acts upstream of T cell migration IMP
IMP: Inferred from mutant phenotype
21236258 MGI
acts upstream of cytokine production involved in immune response IMP
IMP: Inferred from mutant phenotype
21236258 MGI
acts upstream of or within defense response to Gram-negative bacterium IMP
IMP: Inferred from mutant phenotype
22801499 MGI
acts upstream of or within defense response to Gram-positive bacterium IMP
IMP: Inferred from mutant phenotype
22801499 MGI
acts upstream of or within negative regulation of CD4-positive, alpha-beta T cell proliferation IDA
IDA: Inferred from direct assay
15568026 MGI
acts upstream of or within positive regulation of T cell migration IMP
IMP: Inferred from mutant phenotype
21236258 MGI
acts upstream of or within positive regulation of cytokine production involved in immune response IMP
IMP: Inferred from mutant phenotype
21236258 MGI
acts upstream of or within positive regulation of peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
15568026 MGI
Cellular Component GO Annotation Evidence References Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
15568026 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tumor necrosis factor receptor superfamily member 14

  • herpes virus entry mediator A

  • herpesvirus entry mediator A

  • tumor necrosis factor receptor-like 2

Recombinant Tnfrsf14 Proteins

Cat. No. Product Name Accession Purity
HY-P71992 HVEM/TNFRSF14 Protein, Mouse (HEK293, hFc) Q80WM9 (Q39-V207) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P73108 HVEM/TNFRSF14 Protein, Mouse (HEK293, His-Fc) Q80WM9/NP_849262.1 (P40-Q206) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14806 TNFRSF14 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174517 Human TNFRSF14 mRNA / Unkown
HY-RS17316 Tnfrsf14 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23771 Tnfrsf14 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tnfrsf14 NCBI NCBI:8764