Micall2 - MICAL-like 2 Gene

Also Known as JRAB; MICAL-L2; mFLJ00139; A930021H16Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 231830

Summary

Enables cytoskeletal protein binding activity and small GTPase binding activity. Involved in several processes, including actin Cytoskeleton organization; bicellular tight junction assembly; and substrate adhesion-dependent cell spreading. Acts upstream of or within endocytic recycling. Located in several cellular components, including actin filament bundle; bicellular tight junction; and recycling endosome. Colocalizes with stress fiber. Is expressed in several structures, including chondrocranium; liver lobe; medulla oblongata basal plate; submandibular gland primordium; and vibrissa. Orthologous to human MICALL2 (MICAL like 2). [provided by Alliance of Genome Resources, Apr 2022]

Micall2 Products (1)

mRNA Protein Name
NM_174850.3 NP_777275.2 MICAL-like protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables actin filament binding IDA
IDA: Inferred from direct assay
18332111 MGI
enables actinin binding IPI
IPI: Inferred from physical interaction
23890175 MGI
enables filamin binding IDA
IDA: Inferred from direct assay
23890175 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16525024 MGI
enables small GTPase binding IPI
IPI: Inferred from physical interaction
18094055 MGI
Biological Process GO Annotation Evidence References Source
involved in actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
23890175 MGI
involved in actin filament polymerization IMP
IMP: Inferred from mutant phenotype
20008558 MGI
involved in bicellular tight junction assembly IMP
IMP: Inferred from mutant phenotype
18094055 MGI
acts upstream of or within endocytic recycling IDA
IDA: Inferred from direct assay
16525024 MGI
involved in endocytic recycling IMP
IMP: Inferred from mutant phenotype
18094055 MGI
involved in neuron projection development IMP
IMP: Inferred from mutant phenotype
20008558 MGI
involved in substrate adhesion-dependent cell spreading IMP
IMP: Inferred from mutant phenotype
23890175 MGI
Cellular Component GO Annotation Evidence References Source
located in actin filament bundle IDA
IDA: Inferred from direct assay
16525024 MGI
located in bicellular tight junction IDA
IDA: Inferred from direct assay
16525024 MGI
located in cell-cell junction IDA
IDA: Inferred from direct assay
18332111 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
18094055 MGI
located in recycling endosome IDA
IDA: Inferred from direct assay
18094055 MGI
colocalizes with stress fiber IDA
IDA: Inferred from direct assay
23890175 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

MICAL-like protein 2

  • junctional Rab13-binding protein

  • molecule interacting with CasL-like 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08429 MICALL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22011 Micall2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28529 Micall2 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Micall2 NCBI NCBI:79778