Ffar1 - free fatty acid receptor 1 Gene

Also Known as Gpr40

Species: Mus musculus

Gene Type: protein coding

Gene ID: 233081

Summary

Enables bioactive lipid receptor activity. Involved in glucose homeostasis; positive regulation of transport; and response to fatty acid. Acts upstream of or within Insulin secretion. Located in plasma membrane. Is expressed in gut and male reproductive gland or organ. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human FFAR1 (Free Fatty Acid Receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Ffar1 Products (1)

mRNA	Protein	Name
NM_194057.3	NP_918946.2	free fatty acid receptor 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables G protein-coupled receptor activity	IDA IDA: Inferred from direct assay	31664108	MGI
enables bioactive lipid receptor activity	IDA IDA: Inferred from direct assay	24130766	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within glucose homeostasis	IMP IMP: Inferred from mutant phenotype	17395749	MGI
involved in glucose homeostasis	IMP IMP: Inferred from mutant phenotype	24130766	MGI
acts upstream of or within insulin secretion	IMP IMP: Inferred from mutant phenotype	17395749	MGI
involved in ion channel modulating, G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	31664108	MGI
involved in ligand-gated ion channel signaling pathway	IDA IDA: Inferred from direct assay	31664108	MGI
involved in phospholipase C-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	31664108	MGI
involved in positive regulation of calcium ion transport	IDA IDA: Inferred from direct assay	24130766	MGI
involved in positive regulation of insulin secretion	IDA IDA: Inferred from direct assay	31664108	MGI
involved in positive regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	24130766	MGI
involved in response to fatty acid	IDA IDA: Inferred from direct assay	24130766	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	24130766	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
free fatty acid receptor 1	G protein-coupled receptor 40 G protein-coupled receptor GPR40

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-153667	MK-2305	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ffar1	NCBI	NCBI:2864