SUN1 - Sad1 and UNC84 domain containing 1 Gene

Also Known as UNC84A

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23353

About SUN1

Cytogenetic location: 7p22.3 Genomic coordinates (GRCh38): 7:815,557-874,934 (from NCBI)

This gene has 35 transcripts (splice variants), 264 orthologues and 4 paralogues. Ubiquitous expression in endometrium (RPKM 45.0), skin (RPKM 41.1) and 25 other tissues.

Summary

This gene is a member of the unc-84 homolog family and encodes a nuclear envelope protein with an Unc84 (SUN) domain. The protein is involved in nuclear anchorage and migration. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2019]

SUN1 Products (72)

mRNA	Protein	Name
NM_001130965.3	NP_001124437.1	SUN domain-containing protein 1 isoform a
NM_001171944.2	NP_001165415.1	SUN domain-containing protein 1 isoform c
NM_001171945.2	NP_001165416.1	SUN domain-containing protein 1 isoform d
NM_001171946.2	NP_001165417.1	SUN domain-containing protein 1 isoform e
NM_001367633.1	NP_001354562.1	SUN domain-containing protein 1 isoform a
NM_001367634.1	NP_001354563.1	SUN domain-containing protein 1 isoform a
NM_001367635.1	NP_001354564.1	SUN domain-containing protein 1 isoform f
NM_001367636.1	NP_001354565.1	SUN domain-containing protein 1 isoform g
NM_001367637.1	NP_001354566.1	SUN domain-containing protein 1 isoform h
NM_001367638.1	NP_001354567.1	SUN domain-containing protein 1 isoform i
NM_001367639.1	NP_001354568.1	SUN domain-containing protein 1 isoform j
NM_001367640.1	NP_001354569.1	SUN domain-containing protein 1 isoform k
NM_001367641.1	NP_001354570.1	SUN domain-containing protein 1 isoform l
NM_001367642.1	NP_001354571.1	SUN domain-containing protein 1 isoform m
NM_001367643.1	NP_001354572.1	SUN domain-containing protein 1 isoform n
NM_001367644.1	NP_001354573.1	SUN domain-containing protein 1 isoform o
NM_001367645.1	NP_001354574.1	SUN domain-containing protein 1 isoform p
NM_001367646.1	NP_001354575.1	SUN domain-containing protein 1 isoform q
NM_001367647.1	NP_001354576.1	SUN domain-containing protein 1 isoform r
NM_001367648.1	NP_001354577.1	SUN domain-containing protein 1 isoform s
NM_001367649.1	NP_001354578.1	SUN domain-containing protein 1 isoform t
NM_001367651.1	NP_001354580.1	SUN domain-containing protein 1 isoform u
NM_001367653.1	NP_001354582.1	SUN domain-containing protein 1 isoform v
NM_001367655.1	NP_001354584.1	SUN domain-containing protein 1 isoform w
NM_001367658.1	NP_001354587.1	SUN domain-containing protein 1 isoform x
NM_001367660.1	NP_001354589.1	SUN domain-containing protein 1 isoform y
NM_001367662.1	NP_001354591.1	SUN domain-containing protein 1 isoform z
NM_001367664.1	NP_001354593.1	SUN domain-containing protein 1 isoform aa
NM_001367665.1	NP_001354594.1	SUN domain-containing protein 1 isoform bb
NM_001367666.1	NP_001354595.1	SUN domain-containing protein 1 isoform cc
NM_001367667.1	NP_001354596.1	SUN domain-containing protein 1 isoform dd
NM_001367668.1	NP_001354597.1	SUN domain-containing protein 1 isoform ee
NM_001367669.1	NP_001354598.1	SUN domain-containing protein 1 isoform ff
NM_001367670.1	NP_001354599.1	SUN domain-containing protein 1 isoform gg
NM_001367671.1	NP_001354600.1	SUN domain-containing protein 1 isoform hh
NM_001367672.1	NP_001354601.1	SUN domain-containing protein 1 isoform ii
NM_001367673.1	NP_001354602.1	SUN domain-containing protein 1 isoform jj
NM_001367674.1	NP_001354603.1	SUN domain-containing protein 1 isoform kk
NM_001367675.1	NP_001354604.1	SUN domain-containing protein 1 isoform ll
NM_001367676.1	NP_001354605.1	SUN domain-containing protein 1 isoform mm
NM_001367677.1	NP_001354606.1	SUN domain-containing protein 1 isoform nn
NM_001367678.1	NP_001354607.1	SUN domain-containing protein 1 isoform oo
NM_001367679.1	NP_001354608.1	SUN domain-containing protein 1 isoform pp
NM_001367680.1	NP_001354609.1	SUN domain-containing protein 1 isoform qq
NM_001367681.1	NP_001354610.1	SUN domain-containing protein 1 isoform rr
NM_001367682.1	NP_001354611.1	SUN domain-containing protein 1 isoform ss
NM_001367683.1	NP_001354612.1	SUN domain-containing protein 1 isoform tt
NM_001367684.1	NP_001354613.1	SUN domain-containing protein 1 isoform uu
NM_001367685.1	NP_001354614.1	SUN domain-containing protein 1 isoform vv
NM_001367686.1	NP_001354615.1	SUN domain-containing protein 1 isoform ww
NM_001367687.1	NP_001354616.1	SUN domain-containing protein 1 isoform xx
NM_001367688.1	NP_001354617.1	SUN domain-containing protein 1 isoform yy
NM_001367689.1	NP_001354618.1	SUN domain-containing protein 1 isoform zz
NM_001367690.1	NP_001354619.1	SUN domain-containing protein 1 isoform aaa
NM_001367691.1	NP_001354620.1	SUN domain-containing protein 1 isoform bbb
NM_001367692.1	NP_001354621.1	SUN domain-containing protein 1 isoform ccc
NM_001367693.1	NP_001354622.1	SUN domain-containing protein 1 isoform ddd
NM_001367694.1	NP_001354623.1	SUN domain-containing protein 1 isoform eee
NM_001367695.1	NP_001354624.1	SUN domain-containing protein 1 isoform fff
NM_001367696.1	NP_001354625.1	SUN domain-containing protein 1 isoform ggg
NM_001367697.1	NP_001354626.1	SUN domain-containing protein 1 isoform hhh
NM_001367698.1	NP_001354627.1	SUN domain-containing protein 1 isoform iii
NM_001367699.1	NP_001354628.1	SUN domain-containing protein 1 isoform jjj
NM_001367700.1	NP_001354629.1	SUN domain-containing protein 1 isoform kkk
NM_001367701.1	NP_001354630.1	SUN domain-containing protein 1 isoform lll
NM_001367702.1	NP_001354631.1	SUN domain-containing protein 1 isoform mmm
NM_001367703.1	NP_001354632.1	SUN domain-containing protein 1 isoform nnn
NM_001367704.1	NP_001354633.1	SUN domain-containing protein 1 isoform ooo
NM_001367705.1	NP_001354634.1	SUN domain-containing protein 1 isoform ppp
NM_001367706.1	NP_001354635.1	SUN domain-containing protein 1 isoform qqq
NM_001367708.1	NP_001354637.1	SUN domain-containing protein 1 isoform sss
NM_025154.6	NP_079430.3	SUN domain-containing protein 1 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cytoskeleton-nuclear membrane anchor activity	IDA IDA: Inferred from direct assay	18396275	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	22632968	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18396275	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in nuclear matrix anchoring at nuclear membrane	IDA IDA: Inferred from direct assay	18396275	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of meiotic nuclear membrane microtubule tethering complex	IDA IDA: Inferred from direct assay	18396275	GOA
located in nuclear envelope	IDA IDA: Inferred from direct assay	19933576	GOA
colocalizes with nuclear envelope	IMP IMP: Inferred from mutant phenotype	21610090	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SUN1 Protein Structure

MRP

Sad1_UNC

0
200
400
600
785 a.a.

Protein Preferred Names	Protein Names
SUN domain-containing protein 1	Sad1 unc-84 domain protein 1

SUN1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SUN1	O94901	KASH5	Homo sapiens	Q8N6L0	Pull Down	33393904
Intra	SUN1	O94901	SYNE4	Homo sapiens	Q8N205	X-Ray Diffraction	33393904
Intra	SUN1	O94901	SYNE4	Homo sapiens	Q8N205	Pull Down	33393904
Intra	SUN1	O94901	SYNE4	Homo sapiens	Q8N205	Biophysical	33393904
Intra	SUN1	O94901	IRAG2	Homo sapiens	Q12912	X-Ray Diffraction	38291267
Intra	SUN1	O94901	SUN1	Homo sapiens	O94901	Comig Non-Denat Gel	22632968
Intra	SUN1	O94901	IRAG2	Homo sapiens	Q12912	SAXS	38291267
Intra	SUN1	O94901	KASH5	Homo sapiens	Q8N6L0	X-Ray Diffraction	33393904
Intra	SUN1	O94901	SYNE4	Homo sapiens	Q8N205	GMS	33393904
Intra	SUN1	O94901	KASH5	Homo sapiens	Q8N6L0	GMS	33393904
Intra	SUN1	O94901	IRAG2	Homo sapiens	Q12912	GMS	38291267
Intra	SUN1	O94901	SYNE1	Homo sapiens	Q8NF91	X-Ray Diffraction	33393904
Intra	SUN1	O94901	SYNE1	Homo sapiens	Q8NF91	Pull Down	33393904
Intra	SUN1	O94901	SYNE1	Homo sapiens	Q8NF91	GMS	33393904

Cross: Cross-species interaction Intra: Intraspecies interaction

SUN1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82277	SUN1 Antibody (YA2022)	WB, IHC-P, ICC/IF, FC	Human

Related Diseases

Diseases	Alias
Deafness, Autosomal Recessive 76	DFNB76 Autosomal Recessive Nonsyndromic Deafness 76 Autosomal Recessive Deafness 76 Deafness, Autosomal Recessive, 76 Deafness, Autosomal Recessive, Type 76
Hyperalphalipoproteinemia 1	Hyperalphalipoproteinemia HALP1 Cetp Deficiency Cholesterol-Ester Transfer Protein Deficiency Familial Hyperalphalipoproteinemia Cholesteryl Ester Transfer Protein Deficiency Cept Deficiency Cholesterol Ester Transfer Protein Deficiency
Emery-Dreifuss Muscular Dystrophy 5, Autosomal Dominant	EDMD5 Autosomal Dominant Emery-Dreifuss Muscular Dystrophy 5 Emd5 Dystrophy, Muscular, Emery-Dreifuss, Type 5, Autosomal Dominant
Deafness, Autosomal Recessive 40	DFNB40 Autosomal Recessive Nonsyndromic Deafness 40 Autosomal Recessive Deafness 40
Deafness, Autosomal Recessive 55	DFNB55 Autosomal Recessive Nonsyndromic Deafness 55 Autosomal Recessive Deafness 55
Emery-Dreifuss Muscular Dystrophy 1, X-Linked	EDMD1 Emd1 Muscular Dystrophy, Tardive, Dreifuss-Emery Type, With Contractures X-Linked Emery-Dreifuss Muscular Dystrophy 1 Humeroperoneal Neuromuscular Disease X-Linked Emery-Dreifuss Muscular Dystrophy Scapuloperoneal Syndrome, X-Linked, Formerly Humeroperoneal Neuromuscular Disease, Formerly Scapuloperoneal Syndrome, X-Linked Muscular Dystrophy Tardive Dreifuss-Emery Type With Contractures Scapuloperoneal Syndrome X-Linked X-Edmd Dystrophy, Muscular, Emery-Dreifuss, Type 1, X-Linked
Emery-Dreifuss Muscular Dystrophy 2, Autosomal Dominant	EDMD2 Autosomal Dominant Emery-Dreifuss Muscular Dystrophy Emd2 Emery-Dreifuss Muscular Dystrophy, Autosomal Dominant Scapuloilioperoneal Atrophy With Cardiopathy Muscular Dystrophy With Early Contractures And Cardiomyopathy, Autosomal Dominant Hauptmann-Thannhauser Muscular Dystrophy Cardiomyopathy, Dilated, With Quadriceps Myopathy Autosomal Dominant Emery-Dreifuss Muscular Dystrophy 2 Muscular Dystrophy, Limb-Girdle, Type 1b Muscular Dystrophy, Limb-Girdle, Type 1b, Formerly Lgmd1b, Formerly Muscular Dystrophy, Proximal, Type 1b, Formerly Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 1b Lgmd1b Limb-Girdle Muscular Dystrophy 1b Muscular Dystrophy, Proximal, Type 1b Muscular Dystrophy With Early Contractures And Cardiomyopathy Autosomal Dominant
Emery-Dreifuss Muscular Dystrophy 3, Autosomal Recessive	EDMD3 Autosomal Recessive Emery-Dreifuss Muscular Dystrophy 3 Autosomal Recessive Emery-Dreifuss Muscular Dystrophy Emery-Dreifuss Muscular Dystrophy Atypical Autosomal Recessive Dystrophy, Muscular, Emery-Dreifuss, Type 3, Autosomal Recessive Emery-Dreifuss Muscular Dystrophy 3
Emery-Dreifuss Muscular Dystrophy 7, Autosomal Dominant	EDMD7 Autosomal Dominant Emery-Dreifuss Muscular Dystrophy 7 Emery-Dreifuss Muscular Dystrophy 7, Ad Emd7 Dystrophy, Muscular, Emery-Dreifuss, Type 7, Autosomal Dominant
Charcot-Marie-Tooth Disease, Axonal, Type 2b1	Charcot-Marie-Tooth Disease Type 2b1 Charcot-Marie-Tooth Disease, Type 2b1 CMT2B1 Autosomal Recessive Axonal Cmt4c1 Autosomal Recessive Charcot-Marie-Tooth Disease Type 2b1 Charcot-Marie-Tooth Disease Neuronal Type 2b1 Charcot-Marie-Tooth Neuropathy Type 2b1 Charcot-Marie-Tooth Disease, Neuronal, Type 2b1 Charcot-Marie-Tooth Disease, Axonal, Autosomal Recessive, Type 2b1 Charcot-Marie-Tooth Neuropathy, Type 2b1 Autosomal Recessive Axonal Charcot-Marie-Tooth Disease Type 2b1 Ar-Cmt2b1 Charcot-Marie-Tooth Disease 2b1 Charcot-Marie-Tooth Disease Axonal Autosomal Recessive B1 Charcot-Marie-Tooth Disease Axonal Type 2b1
Emery-Dreifuss Muscular Dystrophy 4, Autosomal Dominant	EDMD4 Emery-Dreifuss Muscular Dystrophy 4 With Variable Features Autosomal Dominant Emery-Dreifuss Muscular Dystrophy 4 Emd4 Dystrophy, Muscular, Emery-Dreifuss, Type 4, Autosomal Dominant Emery-Dreifuss Muscular Dystrophy 4
Emery-Dreifuss Muscular Dystrophy	Edmd Emery-Dreifuss Syndrome Muscular Dystrophy, Emery-Dreifuss Humeroperoneal Neuromuscular Disease Muscular Dystrophy, Tardive, Dreifuss-Emery Type, With Contractures Scapuloperoneal Syndrome, X-Linked Benign Scapuloperoneal Muscular Dystrophy With Early Contractures Muscular Dystrophy, Emery-Dreifuss Type Muscular Dystrophy Emery-Dreifuss Dystrophy, Muscular, Emery-Dreifuss Emd - [Emery-Dreifuss Muscular Dystrophy]
Muscular Dystrophy, Congenital, Lmna-Related	Congenital Muscular Dystrophy Congenital Muscular Dystrophy Due To Lmna Mutation MDCL L-Cmd Lmna-Related Congenital Muscular Dystrophy Muscular Dystrophy, Congenital Congenital Muscular Dystrophy Lmna-Related Lmna-Related Cmd Cmd Mdc Muscular Dystrophy Congenital Lmna-Related Dystrophy, Muscular, Congenital, Lmna-Related Dystrophy, Muscular, Congenital Hereditary Muscular Dystrophy Congenital Hereditary Muscular Dystrophy Congenital Progressive Muscular Dystrophy Hereditary Progressive Muscular Dystrophy
Greenberg Dysplasia	Hem Dysplasia Greenberg Skeletal Dysplasia Hem Skeletal Dysplasia GRBGD Hydrops-Ectopic Calcification-Moth-Eaten Skeletal Dysplasia Moth-Eaten Skeletal Dysplasia Chondrodystrophy, Hydropic And Prenatally Lethal Type Hydrops-Ectopic Calcification-Motheaten Syndrome Skeletal Dysplasia, Greenberg Type Autosomal Recessive Lethal Chondrodystrophy With Congenital Hydrops Hydrops, Ectopic Calcification, Moth-Eaten Skeletal Dysplasia Hem Hem/Greenberg Dysplasia Hydrops - Ectopic Calcification - Moth-Eaten Skeletal Dysplasia
Myopathy, X-Linked, With Postural Muscle Atrophy	Emery-Dreifuss Muscular Dystrophy 6, X-Linked XMPMA X-Linked Myopathy With Postural Muscle Atrophy X-Linked Emery-Dreifuss Muscular Dystrophy 6 EDMD6 Emd6
Pelger-Huet Anomaly	PHA Pelger-Huët Anomaly Ovoid Neutrophil Nuclei, Developmental Delay, Epilepsy And Skeletal Abnormalities Pelger Huet Anomaly Pelger-Huet Nuclear Anomaly
Muscular Dystrophy	Muscular Dystrophies Congenital Md Congenital Muscular Dystrophy Cmd Mdc Dystrophy, Muscular Gower'S Muscular Dystrophy Progressive Musclular Dystrophy Pseudohypertrophic Atrophy Pseudohypertrophic Muscle Paralysis Pseudohypertrophic Muscular Atrophy Pseudohypertrophic Muscular Dystrophy Pseudohypertrophic Paralysis Pseudomuscular Hypertrophy
Spinocerebellar Ataxia, Autosomal Recessive 8	Arca1 Autosomal Recessive Cerebellar Ataxia Type 1 SCAR8 Autosomal Recessive Spinocerebellar Ataxia 8 Autosomal Recessive Ataxia, Beauce Type Recessive Ataxia Of Beauce Syne1-Related Autosomal Recessive Cerebellar Ataxia Ataxia, Recessive, Of Beauce Cerebellar Ataxia, Autosomal Recessive, Type 1 Spinocerebellar Ataxia Autosomal Recessive 8 Autosomal Recessive Ataxia Beauce Type Spinocerebellar Ataxia, Autosomal Recessive, 8 Ataxia Recessive Of Beauce Ataxia, Spinocerebellar, Autosomal Recessive, Type 8
Cardiomyopathy, Dilated, 1h	Dilated Cardiomyopathy 1h Dilated Cardiomyopathy With Conduction Defect CMD1H Cardiomyopathy, Dilated, With Conduction Defect
Cardiomyopathy, Dilated, 1a	Dilated Cardiomyopathy 1a Cdcd1 CMD1A Cardiomyopathy, Familial Idiopathic Familial Dilated Cardiomyopathy With Conduction Defect Due To Lmna Mutation Cardiomyopathy, Dilated, With Conduction Defect 1 Cardiomyopathy, Idiopathic Dilated Cardiomyopathy, Congestive Dilated Cardiomyopathy With Conduction Defect 1 Cardiomyopathy Dilated With Conduction Defect Type 1 Cardiomyopathy, Dilated 1a Cardiomyopathy Dilated With Conduction Defect 1 Cardiomyopathy, Dilated, Type 1a
Hutchinson-Gilford Progeria Syndrome	Progeria HGPS Hutchinson-Gilford Syndrome Hutchinson-Gilford Progeria Hutchinson Gilford Syndrome Hutchinson Gilford Progeria Syndrome Hutchinson-Gilford Disease Progeria Of Childhood Hutchinson-Gilford-Progeria Syndrome
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14029	SUN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22335	Sun1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SUN1	VGNC	VGNC:106960
Mus musculus	SUN1	MGD	MGI:1924303
Macaca mulatta	SUN1	VGNC	VGNC:78161
Canis familiaris	SUN1	VGNC	VGNC:46984
Rattus norvegicus	SUN1	RGD	RGD:1359142
Felis catus	SUN1	VGNC	VGNC:65841
Others	SUN1	NCBI