HAUS5 - HAUS augmin like complex subunit 5 Gene

Also Known as dgt5; KIAA0841

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23354

About HAUS5

Cytogenetic location: 19q13.12 Genomic coordinates (GRCh38): 19:35,612,735-35,625,355 (from NCBI)

This gene has 9 transcripts (splice variants) and 93 orthologues. Ubiquitous expression in testis (RPKM 4.9), lymph node (RPKM 4.6) and 25 other tissues.

Summary

HAUS5 is 1 of 8 subunits of the 390-kD human augmin complex, or HAUS complex. The augmin complex was first identified in Drosophila, and its name comes from the Latin verb 'augmentare,' meaning 'to increase.' The augmin complex is a microtubule-binding complex involved in microtubule generation within the mitotic spindle and is vital to mitotic spindle assembly (Goshima et al., 2008 [PubMed 18443220]; Uehara et al., 2009 [PubMed 19369198]).[supplied by OMIM, Jun 2010]

HAUS5 Products (1)

mRNA Protein Name
NM_015302.2 NP_056117.1 HAUS augmin-like complex subunit 5

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19369198 GOA
Biological Process GO Annotation Evidence References Source
involved in centrosome cycle IMP
IMP: Inferred from mutant phenotype
19427217 GOA
involved in spindle assembly IMP
IMP: Inferred from mutant phenotype
19369198 GOA
Cellular Component GO Annotation Evidence References Source
part of HAUS complex IDA
IDA: Inferred from direct assay
19369198 GOA
part of HAUS complex IPI
IPI: Inferred from physical interaction
20360068 GOA
located in centrosome IDA
IDA: Inferred from direct assay
21399614 GOA
located in mitotic spindle microtubule IDA
IDA: Inferred from direct assay
30723163 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HAUS5 Protein Structure

HAUS5

HAUS5: HAUS augmin-like complex subunit 5 (5 - 620)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 633 a.a.
Protein Preferred Names Protein Names

HAUS augmin-like complex subunit 5

HAUS5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HAUS5 O94927 HAUS6 Homo sapiens Q7Z4H7
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06017 HAUS5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta HAUS5 VGNC VGNC:73256
Canis familiaris HAUS5 VGNC VGNC:41605
Bos taurus HAUS5 VGNC VGNC:29760
Mus musculus HAUS5 MGD MGI:1919159
Felis catus HAUS5 VGNC VGNC:62757
Rattus norvegicus HAUS5 RGD RGD:2318093
Others HAUS5 NCBI