SMG5 - SMG5 nonsense mediated mRNA decay factor Gene

Also Known as EST1B; SMG-5; LPTSRP1; LPTS-RP1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23381

About SMG5

Cytogenetic location: 1q22 Genomic coordinates (GRCh38): 1:156,249,224-156,291,516 (from NCBI)

This gene has 5 transcripts (splice variants), 209 orthologues and 1 paralogue. Ubiquitous expression in heart (RPKM 16.7), testis (RPKM 16.4) and 25 other tissues.

Summary

SMG5 is involved in nonsense-mediated mRNA decay (Ohnishi et al., 2003 [PubMed 14636577]).[supplied by OMIM, Mar 2008]

SMG5 Products (5)

mRNA	Protein	Name
NM_001323614.2	NP_001310543.1	nonsense-mediated mRNA decay factor SMG5 isoform 2
NM_001323615.2	NP_001310544.1	nonsense-mediated mRNA decay factor SMG5 isoform 3
NM_001323616.2	NP_001310545.1	nonsense-mediated mRNA decay factor SMG5 isoform 4
NM_001323617.2	NP_001310546.1	nonsense-mediated mRNA decay factor SMG5 isoform 4
NM_015327.3	NP_056142.2	nonsense-mediated mRNA decay factor SMG5 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	16809764	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12699629	GOA
enables protein phosphatase 2A binding	IDA IDA: Inferred from direct assay	14636577	GOA
enables telomerase RNA binding	IPI IPI: Inferred from physical interaction	15857955	GOA
enables telomeric DNA binding	IDA IDA: Inferred from direct assay	17916692	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	16809764	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in regulation of dephosphorylation	IMP IMP: Inferred from mutant phenotype	14636577	GOA
involved in regulation of telomere maintenance	IMP IMP: Inferred from mutant phenotype	16809764	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	14636577	GOA
located in nucleus	IDA IDA: Inferred from direct assay	14636577	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SMG5 Protein Structure

EST1

EST1_DNA_bind

PIN_4

0
200
400
600
800
1016 a.a.

Protein Preferred Names	Protein Names
nonsense-mediated mRNA decay factor SMG5	EST1 telomerase component homolog B

SMG5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SMG5	Q9UPR3	SMG7	Homo sapiens	Q92540	Pull Down	23348841

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Pancreatic Adenosquamous Carcinoma	Adenosquamous Carcinoma Of Pancreas Adenosquamous Carcinoma Of The Pancreas
Metaphyseal Chondrodysplasia, Schmid Type	MCDS Schmid Metaphyseal Chondrodysplasia Metaphyseal Chondrodysplasia Schmid Type Spondylometaphyseal Dysplasia, Japanese Type Japanese Type Spondylometaphyseal Dysplasia Schmid Type Metaphyseal Dysplasia Metaphyseal Chondrodysplasia Type Schmid Schmid Type Metaphyseal Chondrodysplasia SMCD Chondrodysplasia, Metaphyseal, Schmid Type Corneal Dystrophy, Subepithelial Mucinous

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13431	SMG5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SMG5	VGNC	VGNC:65487
Macaca mulatta	SMG5	VGNC	VGNC:77768
Mus musculus	SMG5	MGD	MGI:2447364
Bos taurus	SMG5	VGNC	VGNC:55683
Canis familiaris	SMG5	VGNC	VGNC:46555
Rattus norvegicus	SMG5	RGD	RGD:1584731
Others	SMG5	NCBI