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FOLR2 - folate receptor beta Gene

Also Known as FBP; FOLR1; FR-P3; FRbeta; FR-BETA; BETA-HFR; FBP/PL-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2350

About FOLR2

Cytogenetic location: 11q13.4 Genomic coordinates (GRCh38): 11:72,216,794-72,221,950 (from NCBI)

This gene has 9 transcripts (splice variants), 214 orthologues and 4 paralogues. Broad expression in placenta (RPKM 67.9), gall bladder (RPKM 33.0) and 20 other tissues.

Summary

The protein encoded by this gene is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in Other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. Multiple transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

FOLR2 Products (4)

mRNA	Protein	Name
NM_000803.5	NP_000794.3	folate receptor beta precursor
NM_001113534.2	NP_001107006.1	folate receptor beta precursor
NM_001113535.2	NP_001107007.1	folate receptor beta precursor
NM_001113536.2	NP_001107008.1	folate receptor beta precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables folic acid binding	IDA IDA: Inferred from direct assay	4066659	GOA
enables folic acid receptor activity	IDA IDA: Inferred from direct assay	4066659	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in folic acid transport	IDA IDA: Inferred from direct assay	4066659	GOA
NOT involved in monocyte chemotaxis	IDA IDA: Inferred from direct assay	25015955	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	19116913	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	25015955	GOA
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	4066659	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FOLR2 Protein Structure

Folate_rec

0
100
200
255 a.a.

Protein Preferred Names	Protein Names
folate receptor beta	folate receptor 2 (fetal)

Recombinant FOLR2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76348	FOLR2 Protein, Human (HEK293, His)	P14207 (T17-H228)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78870	FOLR2 Protein, Human (Biotinylated, HEK293, His-Avi)	P14207 (T17-H228)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Neural Tube Defects	Spina Bifida Neural Tube Defect NTD Neural Tube Defects, Susceptibility To Spinal Dysraphism Spina Bifida, Susceptibility To Rachischisis Cleft Spine Open Spine Hydrocele Spinalis Neural Tube Defect Nos Sb - [Spina Bifida] Spinal Hernia Nos Spinal Fissure Nos
Folate Malabsorption, Hereditary	Hereditary Folate Malabsorption Congenital Defect Of Folate Absorption Congenital Folate Malabsorption Folic Acid Transport Defect HFM
Choriocarcinoma Of The Testis	Testicular Choriocarcinoma
Myelomeningocele	Meningomyelocele
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Arthritis	Inflammatory Joint Disease Inflammatory Disorder Of Joint
Thymus Sarcomatoid Carcinoma	Thymic Carcinosarcoma Thymic Sarcomatoid Carcinoma
Subacute Leukemia
Leukemia, Acute Lymphoblastic	Acute Lymphoblastic Leukemia ALL Acute Lymphocytic Leukemia Leukemia, Acute Lymphocytic, Susceptibility To, 1 Acute Lymphoblastic Leukaemia Precursor Lymphoblastic Lymphoma/Leukemia Precursor Lymphoid Neoplasm Leukemia, Acute Lymphoblastic, Susceptibility To B-Cell Acute Lymphoblastic Leukemia Leukemia, Acute Lymphocytic 1 Acute Lymphocytic Leukaemia Acute Lymphoblastic Leukemia/Lymphoma All1 Childhood Acute Lymphoblastic Leukemia Leukemia Acute Lymphoblastic 1 Leukemia Acute Lymphoblastic B-Hyperdiploid Leukemia Acute Lymphocytic Leukemia Acute Lymphocytic 1 Leukemia B-Cell Acute Lymphoblastic Leukemia T-Cell Acute Lymphoblastic Leukemia, Acute Lymphoblastic, 3 ALL3 Lymphoblastic Leukemia Acute Leukemia, Acute, Lymphoblastic Precursor Cell Lymphoblastic Leukemia Lymphoma Leukemia, Lymphocytic, Acute, L1 Leukemia, Acute Lymphoblastic, Susceptibility To, 3

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05030	FOLR2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17201	Folr2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23653	Folr2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990941	Rinatabart		99.47%	Unkown
HY-P992004	KHK2805	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	FOLR2	VGNC	VGNC:72690
Rattus norvegicus	FOLR2	RGD	RGD:1308515
Mus musculus	FOLR2	MGD	MGI:95569
Others	FOLR2	NCBI