Usp3 - ubiquitin specific peptidase 3 Gene
Species: Mus musculus
Summary
The protein encoded by this gene is a chromatin-associated histone 2A and 2B deubiquitinating enzyme that negatively regulates the DNA damage response. Mice deficient for this enzyme have reduced hematopoietic stem cell reserves, demonstrating a requirement in hematopoietic stem cell homeostasis. In addition, knock down of protein levels results in spontaneous tumor development and shortened lifespan, consistent with a function in preserving chromosomal integrity. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
Usp3 Products (3)
| mRNA | Protein | Name |
|---|---|---|
| NM_001302116.1 | NP_001289045.1 | ubiquitin carboxyl-terminal hydrolase 3 isoform 2 |
| NM_001302122.1 | NP_001289051.1 | ubiquitin carboxyl-terminal hydrolase 3 isoform 3 |
| NM_144937.4 | NP_659186.1 | ubiquitin carboxyl-terminal hydrolase 3 isoform 1 |
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
ubiquitin carboxyl-terminal hydrolase 3 |
|
|
Related Agents
- Pre-clinical Phase
Pre-clinical Phase
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-157428 | USP3 ZnF-UBD ligand-1 | 99.61% | Unkown | |
| HY-172193 | UBD1031 | Antagonist | / | Unkown |
| HY-RS15540 | USP3 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS17498 | Usp3 Mouse Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS23955 | Usp3 Rat Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
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