Ago1 - argonaute RISC catalytic subunit 1 Gene

Also Known as Eif2c1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 236511

Summary

This gene encodes a member of the argonaute family of proteins, which associate with small RNAs and have important roles in RNA interference (RNAi) and RNA silencing. This protein binds to MicroRNAs (miRNAs) or small interfering RNAs (siRNAs) and represses translation of mRNAs that are complementary to them. It is also involved in transcriptional gene silencing (TGS) of promoter regions that are complementary to bound short antigene RNAs (agRNAs), as well as in the degradation of miRNA-bound mRNA targets. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target, and that its mRNA could give rise to an additional C-terminally extended isoform by use of an alternative in-frame translation termination codon. [provided by RefSeq, Nov 2015]

Ago1 Products (4)

mRNA	Protein	Name
NM_001317173.1	NP_001304102.1	protein argonaute-1 isoform 1x
NM_001317174.1	NP_001304103.1	protein argonaute-1 isoform 2
NM_001378879.1	NP_001365808.1	protein argonaute-1 isoform 3
NM_153403.3	NP_700452.2	protein argonaute-1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA binding	IDA IDA: Inferred from direct assay	19536157	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	22053081	MGI
enables miRNA binding	IDA IDA: Inferred from direct assay	22053081	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	19269368	MGI
enables transcription cis-regulatory region binding	IMP IMP: Inferred from mutant phenotype	22053081	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within miRNA metabolic process	IDA IDA: Inferred from direct assay	22053081	MGI
acts upstream of or within positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	22053081	MGI
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	26764146	MGI
involved in positive regulation of non-canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	26764146	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	22053081	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	22053081	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in P-body	IDA IDA: Inferred from direct assay	19898466	MGI
part of RISC complex	IDA IDA: Inferred from direct assay	19536157	MGI
located in cytosol	IDA IDA: Inferred from direct assay	22053081	MGI
located in nucleus	IDA IDA: Inferred from direct assay	22053081	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
protein argonaute-1	Piwi/Argonaute family protein meIF2C1 argonaute 1 argonaute RISC catalytic component 1 argonaute1 eIF-2C 1 eIF2C 1 eukaryotic translation initiation factor 2C, 1 mAgo1

Ago1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Ago1	Q8CJG1	Trim32	Mus musculus	Q8CH72	Anti Bait CoIP	19269368

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00452	AGO1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18906	Ago1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25397	Ago1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ago1	NCBI	NCBI:26523