Bves - blood vessel epicardial substance Gene

Also Known as Pop1; mBVES; Popdc1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 23828

Summary

Enables cAMP binding activity. Involved in several processes, including positive regulation of receptor recycling; response to ischemia; and substrate adhesion-dependent cell spreading. Acts upstream of or within several processes, including hematopoietic progenitor cell differentiation; regulation of heart rate; and sinoatrial node cell development. Located in several cellular components, including bicellular tight junction; lateral plasma membrane; and sarcolemma. Is integral component of membrane. Is expressed in several structures, including gut; heart; leg muscle; reproductive system; and respiratory system. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2X. Orthologous to human BVES (blood vessel epicardial substance). [provided by Alliance of Genome Resources, Apr 2022]

Bves Products (1)

mRNA Protein Name
NM_024285.3 NP_077247.1 blood vessel epicardial substance

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cAMP binding IDA
IDA: Inferred from direct assay
22354168 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16188940 MGI
Biological Process GO Annotation Evidence References Source
involved in cell migration involved in heart development IMP
IMP: Inferred from mutant phenotype
24048452 MGI
acts upstream of or within hematopoietic progenitor cell differentiation IGI
IGI: Inferred from genetic interaction
24029230 MGI
involved in positive regulation of locomotion IDA
IDA: Inferred from direct assay
18541910 MGI
involved in positive regulation of receptor recycling IDA
IDA: Inferred from direct assay
20057356 MGI
involved in regulation of GTPase activity IDA
IDA: Inferred from direct assay
18541910 MGI
involved in regulation of cell shape IDA
IDA: Inferred from direct assay
18541910 MGI
involved in regulation of endocytic recycling IMP
IMP: Inferred from mutant phenotype
24048452 MGI
acts upstream of or within regulation of heart rate IMP
IMP: Inferred from mutant phenotype
22354168 MGI
acts upstream of or within regulation of membrane potential IGI
IGI: Inferred from genetic interaction
22354168 MGI
involved in response to ischemia IMP
IMP: Inferred from mutant phenotype
24066022 MGI
acts upstream of or within sinoatrial node cell development IMP
IMP: Inferred from mutant phenotype
22354168 MGI
involved in substrate adhesion-dependent cell spreading IDA
IDA: Inferred from direct assay
20057356 MGI
involved in vesicle docking IMP
IMP: Inferred from mutant phenotype
24048452 MGI
involved in vesicle-mediated transport IDA
IDA: Inferred from direct assay
20057356 MGI
Cellular Component GO Annotation Evidence References Source
located in bicellular tight junction IDA
IDA: Inferred from direct assay
16188940 MGI
located in caveola IDA
IDA: Inferred from direct assay
24066022 MGI
located in cell projection membrane IDA
IDA: Inferred from direct assay
24048452 MGI
located in lateral plasma membrane IDA
IDA: Inferred from direct assay
16188940 MGI
located in membrane IDA
IDA: Inferred from direct assay
10882522 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
18541910 MGI
located in sarcolemma IDA
IDA: Inferred from direct assay
24066022 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

blood vessel epicardial substance

  • popeye 1

  • popeye domain-containing protein 1

  • popeye protein 1

Bves Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Bves Q9ES83 Arhgef25 Mus musculus Q9CWR0
Y2H
18541910
Intra
Bves Q9ES83 Arhgef25 Mus musculus Q9CWR0
Pull Down
18541910
Cross
Bves Q9ES83 Vamp3 Rattus norvegicus P63025
IF
20057356
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P11741 BV2 / Unkown
HY-RS01687 BVES Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bves NCBI NCBI:11149