Gpr68 - G protein-coupled receptor 68 Gene

Also Known as Ogr1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 238377

About Gpr68

Chromosome 12: 100,842,941-100,874,457 reverse strand.GRCm39:CM001005.3

This gene has 7 transcripts (splice variants), 197 orthologues, 1 paralogue and is associated with 17 phenotypes. Broad expression in spleen adult (RPKM 5.7), thymus adult (RPKM 5.5) and 2 other tissues.

Summary

Predicted to enable G protein-coupled receptor activity. Acts upstream of or within cellular response to pH; positive regulation of Insulin secretion involved in cellular response to glucose stimulus; and regulation of myeloid leukocyte differentiation. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Is expressed in early conceptus; primary oocyte; and secondary oocyte. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 2A6. Orthologous to human GPR68 (G protein-coupled receptor 68). [provided by Alliance of Genome Resources, Apr 2022]

Gpr68 Products (4)

mRNA Protein Name
NM_175493.4 NP_780702.1 ovarian cancer G-protein coupled receptor 1
NM_001177673.1 NP_001171144.1 ovarian cancer G-protein coupled receptor 1
NM_001403314.1 NP_001390243.1 ovarian cancer G-protein coupled receptor 1
NM_001177674.2 NP_001171145.1 ovarian cancer G-protein coupled receptor 1

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to pH IMP
IMP: Inferred from mutant phenotype
22733973 MGI
acts upstream of insulin secretion IMP
IMP: Inferred from mutant phenotype
22733973 MGI
acts upstream of monocyte differentiation IMP
IMP: Inferred from mutant phenotype
19479052 MGI
acts upstream of or within negative regulation of monocyte differentiation IMP
IMP: Inferred from mutant phenotype
19479052 MGI
acts upstream of osteoclast development IMP
IMP: Inferred from mutant phenotype
19479052 MGI
acts upstream of or within positive regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
22733973 MGI
acts upstream of or within positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
IMP: Inferred from mutant phenotype
22733973 MGI
acts upstream of or within positive regulation of osteoclast development IMP
IMP: Inferred from mutant phenotype
19479052 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Gpr68 Protein Structure

7tmA_GPR68_OGR1

7tmA_GPR68_OGR1: cd15367 (21 - 48)

7tmA_GPR68_OGR1

7tmA_GPR68_OGR1: cd15367 (21 - 296)

7tmA_GPR68_OGR1

7tmA_GPR68_OGR1: cd15367 (55 - 80)

7tmA_GPR68_OGR1

7tmA_GPR68_OGR1: cd15367 (93 - 123)

7tmA_GPR68_OGR1

7tmA_GPR68_OGR1: cd15367 (135 - 157)

7tmA_GPR68_OGR1

7tmA_GPR68_OGR1: cd15367 (181 - 210)

7tmA_GPR68_OGR1

7tmA_GPR68_OGR1: cd15367 (220 - 250)

7tmA_GPR68_OGR1

7tmA_GPR68_OGR1: cd15367 (264 - 289)

  • 0
  • 100
  • 200
  • 300
  • 365 a.a.
Protein Preferred Names Protein Names

ovarian cancer G-protein coupled receptor 1

  • sphingosylphosphorylcholine receptor

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-154954 Ogremorphin Inhibitor 99.60% Unkown
HY-110279 Ogerin Modulator 99.94% Unkown
HY-134494 MS48107 99.90% Unkown
HY-105791S Sulazepam-d5 Activator / Unkown
HY-169704 Ogerin analogue 1 Control / Unkown
HY-181485 GPR68 antagonist 1 Antagonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gpr68 NCBI NCBI:8111