Ythdc2 - YTH domain containing 2 Gene

Also Known as mYTHDC2; 3010002F02Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 240255

Summary

Enables 3'-5' RNA helicase activity and N6-methyladenosine-containing RNA binding activity. Involved in germline cell cycle switching, mitotic to meiotic cell cycle; oocyte development; and spermatid development. Located in cytoplasm and ribonucleoprotein granule. Is expressed in germ cell of ovary; ovary; seminiferous tubule; spermatocyte; and testis. Orthologous to human YTHDC2 (YTH domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]

Ythdc2 Products (1)

mRNA Protein Name
NM_001163013.1 NP_001156485.1 3'-5' RNA helicase YTHDC2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 3'-5' RNA helicase activity IDA
IDA: Inferred from direct assay
29360036 MGI
enables N6-methyladenosine-containing RNA reader activity IDA
IDA: Inferred from direct assay
28809393 MGI
enables RNA binding IDA
IDA: Inferred from direct assay
29087293 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
26742488 MGI
Biological Process GO Annotation Evidence References Source
involved in germline cell cycle switching, mitotic to meiotic cell cycle IMP
IMP: Inferred from mutant phenotype
29033321 MGI
involved in oocyte development IMP
IMP: Inferred from mutant phenotype
29033321 MGI
involved in spermatid development IMP
IMP: Inferred from mutant phenotype
29033321 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
28380054 MGI
located in ribonucleoprotein granule IDA
IDA: Inferred from direct assay
29087293 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

3'-5' RNA helicase YTHDC2

  • YTH domain-containing protein C2

  • keen to exit meiosis leaving testes under-populated protein

  • ketu

  • probable ATP-dependent RNA helicase YTHDC2

Ythdc2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83572 YTHDC2 Antibody (YA3317) WB, IP Human
HY-P83572A YTHDC2 Antibody (YA3317)(PBS only) WB, IP Human

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-168610 YTH-IN-1 Inhibitor 98.66% Unkown
HY-181117 YTH-IN-2 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ythdc2 NCBI NCBI:64848