Ccl19 - chemokine (C-C motif) ligand 19 Gene

Also Known as ELC; CKb11; MIP3B; Gm2023; Scya19; exodus-3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 24047

Summary

Enables CCR7 Chemokine Receptor binding activity and chemokine activity. Involved in several processes, including positive regulation of T cell activation; positive regulation of cellular component organization; and positive regulation of cytokine production. Located in external side of plasma membrane. Is expressed in Peyer's patch; inguinal lymph node; thymus; and thymus primordium. Orthologous to human CCL19 (C-C motif chemokine ligand 19). [provided by Alliance of Genome Resources, Apr 2022]

Ccl19 Products (1)

mRNA Protein Name
NM_011888.4 NP_036018.1 C-C motif chemokine 19 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables CCR7 chemokine receptor binding IPI
IPI: Inferred from physical interaction
9507024 MGI
enables chemokine activity IDA
IDA: Inferred from direct assay
12200351 MGI
Biological Process GO Annotation Evidence References Source
involved in T cell costimulation IDA
IDA: Inferred from direct assay
15845453 MGI
involved in cell maturation IDA
IDA: Inferred from direct assay
15845453 MGI
involved in dendritic cell chemotaxis IDA
IDA: Inferred from direct assay
12200351 MGI
involved in immunological synapse formation IDA
IDA: Inferred from direct assay
15845453 MGI
involved in mature conventional dendritic cell differentiation IDA
IDA: Inferred from direct assay
15845453 MGI
involved in positive regulation of GTPase activity IDA
IDA: Inferred from direct assay
12609829 MGI
acts upstream of positive regulation of JUN kinase activity IDA
IDA: Inferred from direct assay
16027136 MGI
involved in positive regulation of T cell proliferation IDA
IDA: Inferred from direct assay
15845453 MGI
involved in positive regulation of T-helper 1 cell differentiation IDA
IDA: Inferred from direct assay
15845453 MGI
involved in positive regulation of chemotaxis IDA
IDA: Inferred from direct assay
9507024 MGI
involved in positive regulation of dendritic cell antigen processing and presentation IMP
IMP: Inferred from mutant phenotype
15845453 MGI
involved in positive regulation of dendritic cell dendrite assembly IDA
IDA: Inferred from direct assay
12200351 MGI
involved in positive regulation of endocytosis IDA
IDA: Inferred from direct assay
16027136 MGI
involved in positive regulation of glycoprotein biosynthetic process IDA
IDA: Inferred from direct assay
15845453 MGI
involved in positive regulation of interleukin-1 beta production IDA
IDA: Inferred from direct assay
15845453 MGI
acts upstream of positive regulation of interleukin-12 production IDA
IDA: Inferred from direct assay
15845453 MGI
involved in positive regulation of receptor-mediated endocytosis IDA
IDA: Inferred from direct assay
12609829 MGI
involved in positive regulation of tumor necrosis factor production IDA
IDA: Inferred from direct assay
15845453 MGI
involved in regulation of cell projection assembly IDA
IDA: Inferred from direct assay
12200351 MGI
Cellular Component GO Annotation Evidence References Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
19008373 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

C-C motif chemokine 19

  • EBI-1 ligand chemokine

  • EBI1 ligand chemokine

  • EBV-induced molecule 1 ligand chemokine

  • chemokine CCL19

  • epstein-Barr virus-induced molecule 1 ligand chemokine

  • small-inducible cytokine A19

Recombinant Ccl19 Proteins

Cat. No. Product Name Accession Purity
HY-P7264 MIP-3 beta/CCL19 Protein, Mouse O70460 (G26-S108) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P7264A MIP-3 beta/CCL19 Protein, Mouse (sf9, His) O70460 (G26-S108) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-133073 CCR7 Ligand 1 Antagonist 99.19% Unkown
HY-120427 Cosalane Antagonist 99.78% Unkown
HY-173052 SLW131 / Unkown
HY-RS02088 CCL19 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174764 Human CCL19 mRNA / Unkown
HY-RS16941 Ccl19 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23384 Ccl19 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ccl19 NCBI NCBI:6363