CCL19 - C-C motif chemokine ligand 19 Gene

Also Known as ELC; CKb11; MIP3B; MIP-3b; SCYA19

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6363

About CCL19

Cytogenetic location: 9p13.3 Genomic coordinates (GRCh38): 9:34,689,570-34,691,276 (from NCBI)

This gene has 3 transcripts (splice variants), 96 orthologues and 25 paralogues. Biased expression in appendix (RPKM 274.6), lymph node (RPKM 208.4) and 5 other tissues.

Summary

This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs. It specifically binds to Chemokine Receptor CCR7. [provided by RefSeq, Sep 2014]

CCL19 Products (1)

mRNA	Protein	Name
NM_006274.3	NP_006265.1	C-C motif chemokine 19 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables CCR chemokine receptor binding	IPI IPI: Inferred from physical interaction	20002784	GOA
enables CCR10 chemokine receptor binding	IDA IDA: Inferred from direct assay	10706668	GOA
enables chemokine activity	IDA IDA: Inferred from direct assay	15778365	GOA
enables chemokine receptor binding	IDA IDA: Inferred from direct assay	23341447	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	27044744	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IDA IDA: Inferred from direct assay	12949249	GOA
involved in cellular response to virus	IMP IMP: Inferred from mutant phenotype	25754930	GOA
involved in dendritic cell chemotaxis	IDA IDA: Inferred from direct assay	15778365	GOA
involved in establishment of T cell polarity	IDA IDA: Inferred from direct assay	12729902	GOA
involved in killing of cells of another organism	IDA IDA: Inferred from direct assay	12949249	GOA
involved in myeloid dendritic cell chemotaxis	IDA IDA: Inferred from direct assay	14592837	GOA
involved in negative regulation of dendritic cell apoptotic process	IDA IDA: Inferred from direct assay	15059845	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	15778365	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	25754930	GOA
involved in positive regulation of JNK cascade	IDA IDA: Inferred from direct assay	15778365	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	15059845	GOA
involved in positive regulation of cell motility	IDA IDA: Inferred from direct assay	15778365	GOA
involved in positive regulation of neutrophil chemotaxis	IDA IDA: Inferred from direct assay	21051556	GOA
involved in positive regulation of non-canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	15059845	GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	15059845	GOA
involved in positive regulation of protein kinase activity	IDA IDA: Inferred from direct assay	14592837	GOA
involved in release of sequestered calcium ion into cytosol	IDA IDA: Inferred from direct assay	14592837	GOA
involved in response to nitric oxide	IDA IDA: Inferred from direct assay	16249377	GOA
involved in response to prostaglandin E	IDA IDA: Inferred from direct assay	14592837	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCL19 Protein Structure

IL8

0
98 a.a.

Protein Preferred Names	Protein Names
C-C motif chemokine 19	CC chemokine ligand 19

CCL19 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CCL19	Q99731	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	CCL19	Q99731	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

CCL19 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81925	CCL19 beta Antibody (YA1670)	WB, FC	Human
HY-P83178	CCL19 beta Antibody (YA2923)	WB	Human

Related Diseases

Diseases	Alias
Polyradiculoneuropathy
Allergic Contact Dermatitis	Dermatitis, Allergic Contact Contact Dermatitis, Allergic Dermatitis Allergic Contact Allergic Contact Eczema Acd - [Allergic Contact Dermatitis] Allergic Contact Dermatitis, Unspecified Cause Allergic Dermatitis Allergic Eczema Allergy Dermatitis Allergy Eczema Allergic Contact Eczema Due To Clothing Or Footwear Perfume Allergic Contact Dermatitis Allergic Contact Dermatitis Due To Cosmetics Allergic Contact Eczema Due To Cosmetics Or Fragrances Allergic Contact Eczema Due To Dental Materials Allergic Contact Eczema Due To Food Flavours Or Additives Allergic Contact Eczema Due To Hairdressing Products Allergic Contact Eczema Due To Metals Or Metal Salts Allergic Contact Eczema Due To Proteins Allergic Contact Eczema Due To Plastics Or Resin Systems Allergic Contact Eczema Due To Preservatives Or Biocides Allergic Contact Eczema Due To Rubber Chemicals Rubber Dermatitis Allergic Contact Eczema Due To Systemic Medicaments Allergic Contact Eczema Due To Topical Medicaments Allergic Contact Dermatitis Due To Drugs In Contact With Skin
Primary Central Nervous System Lymphoma	Pcnsl Primary Cns Lymphoma Primary Brain Lymphoma Primary Lymphoma, Cns Primary Cerebral Lymphoma
B-Lymphoblastic Leukemia/Lymphoma	B Lymphoblastic Leukemia/Lymphoma B-All Precursor B Lymphoblastic Lymphoma/Leukemia C-All Lymphoblastic Lymphoma, Nos Common Precursor B All Lymphoblastic B-Cell Lymphoma Pro-B All B-Precursor Lymphoma Lbl - [Lymphoblastic Lymphoma]
Sodoku Disease	Spirillosis Sodoku Spirillary Fever Rat-Bite Fever Rat-Bite Fever Due To Spirillum Minus Spirillary Rat-Bite Fever Sokosho
Common Variable Immunodeficiency	Cvid Common Variable Agammaglobulinemia Common Variable Immune Deficiency Acquired Hypogammaglobulinemia Hypogamma-Globulinemia, Acquired Idiopathic Immunoglobulin Deficiency Primary Antibody Deficiency Primary Hypogammaglobulinemia Acquired Agammaglobulinemia Sporadic Hypogammaglobulinemia Common Variable Hypogamma-Globulinemia Immunoglobulin Deficiency, Late-Onset Common Variable Hypogammaglobulinemia Immunodeficiency, Common Variable
Cardiomyopathy, Familial Hypertrophic, 1	Asymmetric Septal Hypertrophy Familial Hypertrophic Cardiomyopathy Hypertrophic Cardiomyopathy 1 CMH1 Hypertrophic Cardiomyopathy 19 CMH Ventricular Hypertrophy, Hereditary Ash Hypertrophic Subaortic Stenosis, Idiopathic Cardiomyopathy, Familial Hypertrophic Cardiomyopathy, Hypertrophic, 1, Digenic Cardiomyopathy, Familial Hypertrophic 1 Hcm Hereditary Ventricular Hypertrophy Idiopathic Hypertrophic Subaortic Stenosis Hypertrophic Cardiomyopathy Cardiomyopathy, Hypertrophic, Familial Cardiomyopathy, Hypertrophic, 1 Familial Asymmetric Septal Hypertrophy Heritable Hypertrophic Cardiomyopathy Fhc Cardiomyopathy, Hypertrophic, Familial, Type 1
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-133073	CCR7 Ligand 1	Antagonist	99.19%	Unkown
HY-120427	Cosalane	Antagonist	99.78%	Unkown
HY-173052	SLW131		/	Unkown
HY-RS02088	CCL19 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174764	Human CCL19 mRNA		/	Unkown
HY-RS16941	Ccl19 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23384	Ccl19 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CCL19	VGNC	VGNC:26946
Canis familiaris	CCL19	VGNC	VGNC:38883
Mus musculus	CCL19	MGD	MGI:1346316
Felis catus	CCL19	VGNC	VGNC:60541
Rattus norvegicus	CCL19	RGD	RGD:1310336
Macaca mulatta	CCL19	VGNC	VGNC:70697
Others	CCL19	NCBI