Spry1 - sprouty RTK signaling antagonist 1 Gene

Also Known as spry-1; sprouty1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 24063

Summary

Involved in negative regulation of cell differentiation and negative regulation of signal transduction. Acts upstream of or within several processes, including bud elongation involved in lung branching; kidney development; and negative regulation of signal transduction. Predicted to be located in Golgi apparatus and nucleoplasm. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; branchial arch; embryo ectoderm; limb; and sensory organ. Orthologous to human SPRY1 (sprouty RTK signaling antagonist 1). [provided by Alliance of Genome Resources, Apr 2022]

Spry1 Products (4)

mRNA Protein Name
NM_001305440.1 NP_001292369.1 protein sprouty homolog 1
NM_001305441.1 NP_001292370.1 protein sprouty homolog 1
NM_001305442.1 NP_001292371.1 protein sprouty homolog 1
NM_011896.3 NP_036026.1 protein sprouty homolog 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16339969 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of ERK1 and ERK2 cascade IGI
IGI: Inferred from genetic interaction
21764747 MGI
acts upstream of or within bud elongation involved in lung branching IGI
IGI: Inferred from genetic interaction
21764747 MGI
acts upstream of or within establishment of mitotic spindle orientation IGI
IGI: Inferred from genetic interaction
21764747 MGI
acts upstream of or within metanephros development IGI
IGI: Inferred from genetic interaction
17537792 MGI
acts upstream of or within negative regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
11585837 MGI
involved in negative regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
29501879 MGI
acts upstream of or within negative regulation of ERK1 and ERK2 cascade IGI
IGI: Inferred from genetic interaction
21764747 MGI
involved in negative regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
19043405 MGI
acts upstream of or within negative regulation of GTPase activity IDA
IDA: Inferred from direct assay
11585837 MGI
acts upstream of or within negative regulation of MAP kinase activity IDA
IDA: Inferred from direct assay
16339969 MGI
acts upstream of or within negative regulation of Ras protein signal transduction IDA
IDA: Inferred from direct assay
11585837 MGI
acts upstream of or within negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
11585837 MGI
involved in negative regulation of epithelial to mesenchymal transition IDA
IDA: Inferred from direct assay
25576668 MGI
acts upstream of or within negative regulation of fibroblast growth factor receptor signaling pathway IDA
IDA: Inferred from direct assay
11585837 MGI
involved in negative regulation of lens fiber cell differentiation IDA
IDA: Inferred from direct assay
29501879 MGI
acts upstream of or within negative regulation of neurotrophin TRK receptor signaling pathway IDA
IDA: Inferred from direct assay
11585837 MGI
involved in negative regulation of transforming growth factor beta receptor signaling pathway IDA
IDA: Inferred from direct assay
25576668 MGI
acts upstream of or within organ induction IMP
IMP: Inferred from mutant phenotype
15691764 MGI
acts upstream of or within ureteric bud development IGI
IGI: Inferred from genetic interaction
15691764 MGI
acts upstream of or within ureteric bud development IMP
IMP: Inferred from mutant phenotype
15691764 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein sprouty homolog 1

  • inhibitor of receptor tyrosine kinases

  • sprouty homolog 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13721 SPRY1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21767 Spry1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28284 Spry1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Spry1 NCBI NCBI:10252