Tnfsf13b - tumor necrosis factor (ligand) superfamily, member 13b Gene

Also Known as BAFF; BLyS; TALL1; THANK; zTNF4; TALL-1; Tnlg7a; TNFSF20; D8Ertd387e

Species: Mus musculus

Gene Type: protein coding
Gene ID: 24099

Summary

Predicted to enable receptor ligand activity. Involved in B cell differentiation and tumor necrosis factor-mediated signaling pathway. Acts upstream of or within B cell homeostasis; positive regulation of germinal center formation; and positive regulation of lymphocyte activation. Predicted to be located in several cellular components, including focal adhesion; perinuclear region of cytoplasm; and plasma membrane. Predicted to be active in extracellular space. Is expressed in genitourinary system. Used to study IgA glomerulonephritis and Sjogren's syndrome. Orthologous to human TNFSF13B (TNF Superfamily member 13b). [provided by Alliance of Genome Resources, Apr 2022]

Tnfsf13b Products (2)

mRNA Protein Name
NM_001347309.1 NP_001334238.1 tumor necrosis factor ligand superfamily member 13B isoform 2
NM_033622.2 NP_296371.1 tumor necrosis factor ligand superfamily member 13B isoform 1

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within B cell costimulation IDA
IDA: Inferred from direct assay
15240667 MGI
acts upstream of or within B cell differentiation IMP
IMP: Inferred from mutant phenotype
17581616 MGI
involved in B cell differentiation IMP
IMP: Inferred from mutant phenotype
18624351 MGI
acts upstream of or within B cell homeostasis IMP
IMP: Inferred from mutant phenotype
14557413 MGI
acts upstream of B cell proliferation IDA
IDA: Inferred from direct assay
15240667 MGI
acts upstream of or within T cell costimulation IDA
IDA: Inferred from direct assay
15240667 MGI
acts upstream of T cell proliferation IDA
IDA: Inferred from direct assay
15240667 MGI
acts upstream of or within cytokine production IDA
IDA: Inferred from direct assay
17581616 MGI
acts upstream of or within cytokine production IMP
IMP: Inferred from mutant phenotype
17581616 MGI
acts upstream of germinal center formation IMP
IMP: Inferred from mutant phenotype
14557413 MGI
acts upstream of or within immunoglobulin production IGI
IGI: Inferred from genetic interaction
15485634 MGI
acts upstream of or within immunoglobulin production IMP
IMP: Inferred from mutant phenotype
17581616 MGI
acts upstream of or within positive regulation of B cell proliferation IDA
IDA: Inferred from direct assay
15240667 MGI
acts upstream of or within positive regulation of T cell proliferation IDA
IDA: Inferred from direct assay
15240667 MGI
acts upstream of or within positive regulation of germinal center formation IMP
IMP: Inferred from mutant phenotype
14557413 MGI
acts upstream of or within regulation of immune response IMP
IMP: Inferred from mutant phenotype
14557413 MGI
acts upstream of or within skin development IMP
IMP: Inferred from mutant phenotype
17581616 MGI
acts upstream of or within transitional one stage B cell differentiation IMP
IMP: Inferred from mutant phenotype
17581616 MGI
involved in tumor necrosis factor-mediated signaling pathway IGI
IGI: Inferred from genetic interaction
18624351 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tumor necrosis factor ligand superfamily member 13B

  • b cell-activating factor

  • tumor necrosis factor ligand 7a

Recombinant Tnfsf13b Proteins

Cat. No. Product Name Accession Purity
HY-P70816 BAFF/TNFSF13B Protein, Mouse (HEK293, Fc) Q9WU72-1 (A127-L309) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P700161AF Animal-Free BAFF/TNFSF13B Protein, Mouse (His) Q9WU72 (A127-L309) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14824 TNFSF13B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17086 Tnfsf13b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23530 Tnfsf13b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992101 Aritinercept Inhibitor 99.9% Unkown
HY-P992479 UBP1213 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tnfsf13b NCBI NCBI:10673