Xrn1 - 5'-3' exoribonuclease 1 Gene

Also Known as exo; Dhm2; mXrn1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 24127

Summary

Enables 5'-3' exoribonuclease activity; G-quadruplex DNA binding activity; and G-quadruplex RNA binding activity. Involved in RNA phosphodiester bond hydrolysis, exonucleolytic. Located in P-body. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human XRN1 (5'-3' exoribonuclease 1). [provided by Alliance of Genome Resources, Apr 2022]

Xrn1 Products (2)

mRNA Protein Name
NM_001311130.1 NP_001298059.1 5'-3' exoribonuclease 1 isoform 2
NM_011916.3 NP_036046.2 5'-3' exoribonuclease 1 isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 5'-3' RNA exonuclease activity IDA
IDA: Inferred from direct assay
9049243 MGI
enables G-quadruplex DNA binding IDA
IDA: Inferred from direct assay
9049243 MGI
enables G-quadruplex RNA binding IDA
IDA: Inferred from direct assay
9049243 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
29033321 MGI
Cellular Component GO Annotation Evidence References Source
located in P-body IDA
IDA: Inferred from direct assay
18625844 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
9049243 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

5'-3' exoribonuclease 1

  • protein Dhm2

  • strand-exchange protein 1 homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-173593A Adenosine-3',5'-bisphosphate ammonium solution (100 mM) Inhibitor 99.16% Unkown
HY-173593 Adenosine-3',5'-bisphosphate Inhibitor / Unkown
HY-RS15902 XRN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21461 Xrn1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27979 Xrn1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Xrn1 NCBI NCBI:54464