AK1 - Ak1 adenylate kinase 1 Gene

Also Known as Ak 1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24183

Summary

Enables adenylate kinase activity. Contributes to phosphotransferase activity, phosphate group as acceptor. Involved in several processes, including nervous system development; nucleobase-containing small molecule metabolic process; and positive regulation of neuron maturation. Located in neuron projection; perinuclear region of cytoplasm; and sarcomere. Biomarker of middle cerebral artery infarction; myocardial infarction; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in congenital nonspherocytic hemolytic anemia and hemolytic anemia. Orthologous to human AK1 (adenylate kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

AK1 Products (1)

mRNA Protein Name
NM_024349.4 NP_077325.2 adenylate kinase isoenzyme 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables adenylate kinase activity IDA
IDA: Inferred from direct assay
8468325 RGD
contributes to phosphotransferase activity, phosphate group as acceptor IDA
IDA: Inferred from direct assay
19049516 RGD
Biological Process GO Annotation Evidence References Source
involved in ADP biosynthetic process IDA
IDA: Inferred from direct assay
19049516 RGD
involved in AMP metabolic process IDA
IDA: Inferred from direct assay
19049516 RGD
involved in cerebellum development IEP
IEP: Inferred from expression pattern
9920788 RGD
involved in inosine biosynthetic process IDA
IDA: Inferred from direct assay
19049516 RGD
involved in muscle organ development IEP
IEP: Inferred from expression pattern
8468325 RGD
involved in neuron differentiation IEP
IEP: Inferred from expression pattern
10101232 RGD
involved in olfactory bulb development IEP
IEP: Inferred from expression pattern
9920788 RGD
involved in positive regulation of D-glucose transmembrane transport IMP
IMP: Inferred from mutant phenotype
21059655 RGD
involved in positive regulation of neuron maturation IEP
IEP: Inferred from expression pattern
9920788 RGD
involved in response to activity IEP
IEP: Inferred from expression pattern
17002673 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
10383487 RGD
involved in response to testosterone IEP
IEP: Inferred from expression pattern
10383487 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
17058275 RGD
Cellular Component GO Annotation Evidence References Source
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
9648858 RGD
located in sarcomere IDA
IDA: Inferred from direct assay
12432079 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

adenylate kinase isoenzyme 1

  • ATP-AMP transphosphorylase 1

  • ATP:AMP phosphotransferase

  • adenylate kinase isoenzyme 1-like

  • adenylate monophosphate kinase

  • myokinase

Recombinant AK1 Proteins

Cat. No. Product Name Accession Purity
HY-P74427 Adenylate Kinase 1/AK1 Protein, Rat (His) P39069 (M1-K194) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-147831 HR-19011 99.64% Unkown
HY-101465 AK-1 Inhibitor 99.84% Unkown
HY-RS00505 AK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174999 JAK3-IN-18 Inhibitor / Unkown
HY-RS04242 EIF2AK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W587827 Thiamine triphosphoric acid ester / Unkown
HY-RS16851 Ak1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22002 Eif2ak1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23292 Ak1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28519 Eif2ak1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens AK1 NCBI NCBI:203