ALDH1A1 - aldehyde dehydrogenase 1 family, member A1 Gene

Also Known as Ahd2; Aldh1; Aldh2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24188

About ALDH1A1

Primary_assembly 1: 218,042,127-218,152,961 forward strand.mRatBN7.2:CM026974.1

This gene has 2 transcripts (splice variants), 200 orthologues, 20 paralogues and is associated with 53 phenotypes. Biased expression in Kidney (RPKM 2289.1), Testes (RPKM 1535.4) and 6 other tissues.

Summary

Enables benzaldehyde dehydrogenase (NAD+) activity; identical protein binding activity; and retinal dehydrogenase activity. Involved in several processes, including estrous cycle; maintenance of lens transparency; and retinoic acid metabolic process. Located in cytoplasm and nucleus. Orthologous to human ALDH1A1 (aldehyde dehydrogenase 1 family member A1). [provided by Alliance of Genome Resources, Apr 2022]

ALDH1A1 Products (1)

mRNA Protein Name
NM_022407.3 NP_071852.2 aldehyde dehydrogenase 1A1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables aldehyde dehydrogenase (NAD+) activity IDA
IDA: Inferred from direct assay
10998257 RGD
enables aldehyde dehydrogenase (NAD+) activity IMP
IMP: Inferred from mutant phenotype
15623782 RGD
enables benzaldehyde dehydrogenase (NAD+) activity IDA
IDA: Inferred from direct assay
10998257 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
10998257 RGD
enables retinal dehydrogenase activity IDA
IDA: Inferred from direct assay
7832787 RGD
Biological Process GO Annotation Evidence References Source
involved in 9-cis-retinoic acid metabolic process IDA
IDA: Inferred from direct assay
17167544 RGD
involved in cellular detoxification of aldehyde IMP
IMP: Inferred from mutant phenotype
15623782 RGD
involved in estrous cycle IEP
IEP: Inferred from expression pattern
18202528 RGD
involved in kidney development IEP
IEP: Inferred from expression pattern
15567713 RGD
involved in liver development IEP
IEP: Inferred from expression pattern
14729401 RGD
involved in maintenance of lens transparency IMP
IMP: Inferred from mutant phenotype
15623782 RGD
involved in midgut development IEP
IEP: Inferred from expression pattern
15964596 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
18202528 RGD
involved in response to ethanol IDA
IDA: Inferred from direct assay
17673211 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
18807137 RGD
involved in response to oxidative stress IMP
IMP: Inferred from mutant phenotype
15623782 RGD
involved in response to retinoic acid IEP
IEP: Inferred from expression pattern
11169459 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
10323328 RGD
involved in retinoic acid biosynthetic process IMP
IMP: Inferred from mutant phenotype
21138835 RGD
involved in retinoid metabolic process IDA
IDA: Inferred from direct assay
7832787 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ALDH1A1 Protein Structure

ALDH_F1AB_F2_RALDH1

ALDH_F1AB_F2_RALDH1: cd07141 (33 - 513)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 520 a.a.
Protein Preferred Names Protein Names

aldehyde dehydrogenase 1A1

retinal dehydrogenase 1

  • 3-deoxyglucosone dehydrogenase

  • ALDH-E1

  • ALHDII

  • RALDH 1

  • aldehyde dehydrogenase 1, subfamily A1

  • aldehyde dehydrogenase 2

  • aldehyde dehydrogenase family 1 member A1

  • aldehyde dehydrogenase family 1, subfamily A1

  • aldehyde dehydrogenase, cytosolic

  • ralDH1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (35)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-138097 α-NETA ≥98.0% Unkown
HY-18768 NCT-501 99.59% Unkown
HY-125085 ALDH3A1-IN-3 Inhibitor 99.43% Unkown
HY-122912 ALDH1A inhibitor 673A 99.15% Unkown
HY-148466 IGUANA-1 Inhibitor 98.93% Unkown
HY-110294 CM037 Inhibitor 99.55% Unkown
HY-135841 CM010 Inhibitor 99.70% Unkown
HY-112278 NCT-506 Inhibitor 99.93% Unkown
HY-146683 KS106 99.87% Unkown
HY-146682 KS100 99.61% Unkown
HY-126003 ALDH1A1-IN-2 Inhibitor 99.31% Unkown
HY-112277 NCT-505 Inhibitor 99.37% Unkown
HY-123621 GNE-375 Inhibitor 99.93% Unkown
HY-155816 PROTAC NSD3 degrader-1 99.40% Unkown
HY-148243 IGUANA-1 free base Inhibitor 99.69% Unkown
HY-157567 FSI-TN42 Inhibitor 98.07% Unkown
HY-128299 ALDH3A1-IN-4 Inhibitor 99.91% Unkown
HY-134917 Aldi-2 Inhibitor / Unkown
HY-146240 ALDH1A1-IN-3 Inhibitor / Unkown
HY-157872 ALDH1A1-IN-4 Inhibitor / Unkown
HY-158026 ALDH1A1-IN-5 Inhibitor / Unkown
HY-159111 KS124 / Unkown
HY-187170 BM-51 Inhibitor / Unkown
HY-18768A NCT-501 hydrochloride Inhibitor / Unkown
HY-D3185 AlDeSense AM / Unkown
HY-RS00560 ALDH1A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00561 Aldh1a1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS00562 ALDH1A1 Rat Pre-designed siRNA Set A / Unkown
HY-RS00565 ALDH1B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00566 ALDH1L1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-180872 ALDH1A1 modulator-1 / Unkown
HY-RS17566 Aldh1b1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21224 Aldh1l1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24026 Aldh1b1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27740 Aldh1l1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens ALDH1A1 NCBI NCBI:216