ALDH1A1 - aldehyde dehydrogenase 1 family member A1 Gene

Also Known as ALDC; ALDH1; HEL-9; HEL12; PUMB1; ALDH11; RALDH1; ALDH-E1; HEL-S-53e

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 216

About ALDH1A1

Cytogenetic location: 9q21.13 Genomic coordinates (GRCh38): 9:72,900,671-72,953,053 (from NCBI)

This gene has 7 transcripts (splice variants), 207 orthologues and 17 paralogues. Broad expression in liver (RPKM 321.0), duodenum (RPKM 249.1) and 18 other tissues.

Summary

The protein encoded by this gene belongs to the aldehyde dehydrogenase family. Aldehyde dehydrogenase is the next enzyme after alcohol dehydrogenase in the major pathway of alcohol metabolism. There are two major aldehyde dehydrogenase isozymes in the liver, cytosolic and mitochondrial, which are encoded by distinct genes, and can be distinguished by their electrophoretic mobility, kinetic properties, and subcellular localization. This gene encodes the cytosolic isozyme. Studies in mice show that through its role in retinol metabolism, this gene may also be involved in the regulation of the metabolic responses to high-fat diet. [provided by RefSeq, Mar 2011]

ALDH1A1 Products (1)

mRNA	Protein	Name
NM_000689.5	NP_000680.2	aldehyde dehydrogenase 1A1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables 3-deoxyglucosone dehydrogenase activity	IDA IDA: Inferred from direct assay	17175089	GOA
enables aldehyde dehydrogenase (NAD+) activity	IDA IDA: Inferred from direct assay	4015840	GOA
enables aldehyde dehydrogenase (NAD+) activity	IMP IMP: Inferred from mutant phenotype	15623782	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular detoxification of aldehyde	IMP IMP: Inferred from mutant phenotype	15623782	GOA
involved in fructosamine catabolic process	IDA IDA: Inferred from direct assay	17175089	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	12941160	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ALDH1A1 Protein Structure

Aldedh

0
100
200
300
400
501 a.a.

Protein Preferred Names	Protein Names
aldehyde dehydrogenase 1A1	3-deoxyglucosone dehydrogenase ALDH class 1 ALHDII RALDH 1 acetaldehyde dehydrogenase 1 aldehyde dehydrogenase 1, soluble aldehyde dehydrogenase, liver cytosolic epididymis luminal protein 12 epididymis luminal protein 9 epididymis secretory sperm binding protein Li 53e retinal dehydrogenase 1 retinaldehyde dehydrogenase 1

ALDH1A1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ALDH1A1	P00352	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
Intra	ALDH1A1	P00352	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053
Intra	ALDH1A1	P00352	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
Intra	ALDH1A1	P00352	GFAP	Homo sapiens	P14136	Y2H Pooling	32814053
Intra	ALDH1A1	P00352	GFAP	Homo sapiens	P14136	Validated Y2H	32814053
Intra	ALDH1A1	P00352	GFAP	Homo sapiens	P14136	Y2H Array	32814053
Intra	ALDH1A1	P00352	DBH	Homo sapiens	P09172	Y2H Pooling	32814053
Intra	ALDH1A1	P00352	DBH	Homo sapiens	P09172	Validated Y2H	32814053
Intra	ALDH1A1	P00352	DBH	Homo sapiens	P09172	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ALDH1A1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7474	ALDH1A1 Protein, Human (His)	P00352 (M1-S501)	≥ 95%, as determined by reducing SDS-PAGE.

ALDH1A1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80536	ALDH1A1 Antibody (YA631)	WB, IHC-P, IP	Human, Mouse
HY-P80536A	ALDH1A1 Antibody (YA631)(PBS only)	WB, IHC-P, IP	Human, Mouse
HY-P83886	ALDH1A1 Antibody (YA3583)	WB, IHC-P, ELISA	Human
HY-P83886A	ALDH1A1 Antibody (YA3583)(PBS only)	WB, IHC-P, ELISA	Human
HY-P83887	ALDH1A1 Antibody (YA3584)	WB, IHC-P, FC, ELISA	Human
HY-P83887A	ALDH1A1 Antibody (YA3584)(PBS only)	WB, IHC-P, FC, ELISA	Human
HY-P85033	ALDH1A1 Antibody (YA4725)	WB, IHC-P, ICC/IF, ELISA	Human
HY-P86223	ALDH1A1 Antibody (YA5915)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Succinic Semialdehyde Dehydrogenase Deficiency	4-Hydroxybutyric Aciduria Ssadh Deficiency Gamma-Hydroxybutyric Aciduria Gaba Metabolic Defect SSADHD Ssadh Succinate-Semialdehyde Dehydrogenase Deficiency Gamma-Hydroxybutyricaciduria 4-Hydroxybutyricaciduria Gamma-Hydroxybutyric Acidemia Succinate Semialdehyde Dehydrogenase Deficiency
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Leukemia, Myeloid, Acute Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Anaerobic Meningitis
Androgen Insensitivity Syndrome	Androgen Resistance Syndrome AIS Testicular Feminization Syndrome Androgen Receptor Deficiency Dihydrotestosterone Receptor Deficiency Dhtr Deficiency Ar Deficiency Testicular Feminization Tfm Androgen Insensitivity Androgen-Insensitivity Syndrome Goldberg-Maxwell Syndrome Complete Androgen Insensitivity Syndrome Cais Feminisation - Testicular Goldberg - Maxwell Syndrome Androgen Insensitivity Syndrome, Complete Morris Syndrome Ary AR Insensitivity Syndrome, Androgen Androgen Insensitivity Nos
Alcohol Dependence	Alcoholism Alcohol Dependence, Susceptibility To Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against Alcohol Dependence, Protection Against Alcoholism, Susceptibility To Alcoholic Intoxication, Chronic Pharyngeal Neoplasms Chronic Alcoholism Dipsomania Alcohol Addiction Ethanol Dependence Chronic Ethanolism Chronic Alcoholic Disease Nos Alcoholic Disease Nos Alcoholic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (34)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-138097	α-NETA		≥98.0%	Unkown
HY-18768	NCT-501		99.59%	Unkown
HY-125085	ALDH3A1-IN-3	Inhibitor	99.43%	Unkown
HY-122912	ALDH1A inhibitor 673A		99.15%	Unkown
HY-148466	IGUANA-1	Inhibitor	98.93%	Unkown
HY-110294	CM037	Inhibitor	99.55%	Unkown
HY-135841	CM010	Inhibitor	99.70%	Unkown
HY-112278	NCT-506	Inhibitor	99.93%	Unkown
HY-146683	KS106		99.87%	Unkown
HY-146682	KS100		99.61%	Unkown
HY-126003	ALDH1A1-IN-2	Inhibitor	99.31%	Unkown
HY-112277	NCT-505	Inhibitor	99.37%	Unkown
HY-123621	GNE-375	Inhibitor	99.93%	Unkown
HY-155816	PROTAC NSD3 degrader-1		99.40%	Unkown
HY-148243	IGUANA-1 free base	Inhibitor	99.69%	Unkown
HY-157567	FSI-TN42	Inhibitor	98.05%	Unkown
HY-128299	ALDH3A1-IN-4	Inhibitor	99.91%	Unkown
HY-134917	Aldi-2	Inhibitor	/	Unkown
HY-146240	ALDH1A1-IN-3	Inhibitor	/	Unkown
HY-157872	ALDH1A1-IN-4	Inhibitor	/	Unkown
HY-158026	ALDH1A1-IN-5	Inhibitor	/	Unkown
HY-159111	KS124		/	Unkown
HY-18768A	NCT-501 hydrochloride	Inhibitor	/	Unkown
HY-D3185	AlDeSense AM		/	Unkown
HY-RS00560	ALDH1A1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00561	Aldh1a1 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS00562	ALDH1A1 Rat Pre-designed siRNA Set A		/	Unkown
HY-RS00565	ALDH1B1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00566	ALDH1L1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-180872	ALDH1A1 modulator-1		/	Unkown
HY-RS17566	Aldh1b1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21224	Aldh1l1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24026	Aldh1b1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27740	Aldh1l1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ALDH1A1	RGD	RGD:2087
Canis familiaris	ALDH1A1	VGNC	VGNC:37782
Felis catus	ALDH1A1	VGNC	VGNC:97345
Bos taurus	ALDH1A1	VGNC	VGNC:25808
Macaca mulatta	ALDH1A1	VGNC	VGNC:81351
Others	ALDH1A1	NCBI