Napepld - N-acyl phosphatidylethanolamine phospholipase D Gene

Also Known as Mbldc1; NAPE-PLD; A530089G06

Species: Mus musculus

Gene Type: protein coding
Gene ID: 242864

Summary

Enables N-acylphosphatidylethanolamine-specific Phospholipase D activity. Involved in several processes, including N-acylphosphatidylethanolamine metabolic process; host-mediated regulation of intestinal microbiota composition; and positive regulation of brown fat cell differentiation. Acts upstream of or within N-acylethanolamine metabolic process. Predicted to be located in Golgi apparatus. Predicted to be active in cytoplasm and membrane-bounded organelle. Orthologous to human NAPEPLD (N-acyl phosphatidylethanolamine Phospholipase D). [provided by Alliance of Genome Resources, Apr 2022]

Napepld Products (4)

mRNA Protein Name
NM_001359963.1 NP_001346892.1 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform b
NM_001359964.1 NP_001346893.1 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform a
NM_001359965.1 NP_001346894.1 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform b
NM_178728.6 NP_848843.1 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables N-acylphosphatidylethanolamine-specific phospholipase D activity IDA
IDA: Inferred from direct assay
14634025 MGI
enables N-acylphosphatidylethanolamine-specific phospholipase D activity IMP
IMP: Inferred from mutant phenotype
16605240 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within N-acylethanolamine metabolic process IDA
IDA: Inferred from direct assay
14634025 MGI
acts upstream of or within N-acylethanolamine metabolic process IMP
IMP: Inferred from mutant phenotype
16818490 MGI
involved in N-acylphosphatidylethanolamine metabolic process IDA
IDA: Inferred from direct assay
15760304 MGI
involved in N-acylphosphatidylethanolamine metabolic process IMP
IMP: Inferred from mutant phenotype
16605240 MGI
involved in host-mediated regulation of intestinal microbiota composition IMP
IMP: Inferred from mutant phenotype
25757720 MGI
involved in positive regulation of brown fat cell differentiation IMP
IMP: Inferred from mutant phenotype
25757720 MGI
involved in positive regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
25757720 MGI
involved in temperature homeostasis IMP
IMP: Inferred from mutant phenotype
25757720 MGI
Cellular Component GO Annotation Evidence References Source
is active in hippocampal mossy fiber to CA3 synapse IDA
IDA: Inferred from direct assay
18234884 MGI
is active in postsynaptic membrane IDA
IDA: Inferred from direct assay
24346263 MGI
is active in presynapse IDA
IDA: Inferred from direct assay
18234884 MGI
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
24346263 MGI
is active in smooth endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
18234884 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D

  • Metallo-beta-lactamase domain containing 1

  • NAPE-hydrolyzing phospholipase D

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-131181 LEI-401 Inhibitor 99.73% Unkown
HY-155773 VU534 Inhibitor 98.10% Unkown
HY-155774 VU533 99.84% Unkown
HY-118994 ARN19874 Inhibitor 99.54% Unkown
HY-RS09031 NAPEPLD Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22012 Napepld Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28530 Napepld Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Napepld NCBI NCBI:222236