Ddc - dopa decarboxylase Gene

Also Known as AADC

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24311

Summary

Enables several functions, including amino acid binding activity; aromatic-L-amino-acid decarboxylase activity; and pyridoxal phosphate binding activity. Involved in several processes, including aminergic neurotransmitter loading into synaptic vesicle; phenol-containing compound biosynthetic process; and response to pyrethroid. Located in axon; neuronal cell body; and synaptic vesicle. Used to study Parkinson's disease. Biomarker of Parkinson's disease; end stage renal disease; nephrotic syndrome; and portal hypertension. Human ortholog(s) of this gene implicated in Parkinson's disease; aromatic L-amino acid decarboxylase deficiency; bipolar disorder; and inherited metabolic disorder. Orthologous to human DDC (dopa decarboxylase). [provided by Alliance of Genome Resources, Apr 2022]

Ddc Products (3)

mRNA Protein Name
NM_001270852.1 NP_001257781.1 aromatic-L-amino-acid decarboxylase isoform a
NM_001270853.1 NP_001257782.1 aromatic-L-amino-acid decarboxylase isoform b
NM_012545.4 NP_036677.1 aromatic-L-amino-acid decarboxylase isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables amino acid binding IDA
IDA: Inferred from direct assay
10569946 RGD
enables aromatic-L-amino-acid decarboxylase activity IDA
IDA: Inferred from direct assay
3379830 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
16981894 RGD
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
19903816 RGD
enables pyridoxal phosphate binding IDA
IDA: Inferred from direct assay
8422386 RGD
Biological Process GO Annotation Evidence References Source
involved in aminergic neurotransmitter loading into synaptic vesicle IDA
IDA: Inferred from direct assay
19903816 RGD
involved in cellular response to alkaloid IEP
IEP: Inferred from expression pattern
18696327 RGD
involved in cellular response to growth factor stimulus IEP
IEP: Inferred from expression pattern
17306206 RGD
involved in cellular response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
18602388 RGD
involved in circadian rhythm IEP
IEP: Inferred from expression pattern
12047348 RGD
involved in dopamine biosynthetic process IDA
IDA: Inferred from direct assay
12703659 RGD
involved in isoquinoline alkaloid metabolic process IEP
IEP: Inferred from expression pattern
18305432 RGD
involved in phytoalexin metabolic process IEP
IEP: Inferred from expression pattern
19185027 RGD
involved in response to pyrethroid IEP
IEP: Inferred from expression pattern
19017407 RGD
involved in serotonin biosynthetic process IDA
IDA: Inferred from direct assay
10027744 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
19589383 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
19589383 RGD
located in synaptic vesicle IDA
IDA: Inferred from direct assay
19903816 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

aromatic-L-amino-acid decarboxylase

  • L-Dopa decarboxylase

  • dopa decarboxylase (aromatic L-amino acid decarboxylase)

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-17392 Zalcitabine Inhibitor 99.81% Yes

Pre-clinical Phase

Bioactive Molecules (15)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-118594 Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate Inhibitor 99.83% Unkown
HY-139997 DDC-01-163 Degrader 99.05% Unkown
HY-151048 JBJ-07-149 Inhibitor 99.09% Unkown
HY-156179 DDC 2′,3′-O-disulfate Inhibitor / Unkown
HY-156180 DDC 3′-O-β-D glucuronide / Unkown
HY-163203 DDC18-8A Inhibitor / Unkown
HY-163461 4F-DDC Inhibitor / Unkown
HY-170351 NH2-PEG2-OMs / Unkown
HY-RS03608 DDC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-170350 Pomalidomide-PEG2-OMs / Unkown
HY-180325 DDC4002 Inhibitor / Unkown
HY-RS16935 Ddc Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23378 Ddc Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W393396 3'-NH2-ddC / Unkown
HY-W784611 3'-NH-Tr-2',3'-ddC(Bz)-5'-CE-Phosphoramidite / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ddc NCBI NCBI:1644