Drd1 - dopamine receptor D1 Gene

Also Known as D1a; Drd-1; Drd1a

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 24316

About Drd1

Cytogenetic location: 5q35.2 Genomic coordinates (GRCh38): 5:175,440,036-175,444,182 (from NCBI)

This gene has 1 transcript (splice variant), 262 orthologues and 25 paralogues.

Summary

Enables several functions, including G protein-coupled receptor binding activity; G-protein alpha-subunit binding activity; and enzyme binding activity. Involved in several processes, including learning; modulation of chemical synaptic transmission; and response to alkaloid. Located in several cellular components, including caveola; dendrite; and neuronal cell body. Is integral component of membrane. Is active in glutamatergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Used to study Parkinson's disease; end stage renal disease; and obesity. Biomarker of several diseases, including heroin dependence; hyperglycemia; neurodegenerative disease (multiple); tracheal stenosis; and ureteral obstruction. Human ortholog(s) of this gene implicated in hypertension and kidney failure. Orthologous to human DRD1 (Dopamine Receptor D1). [provided by Alliance of Genome Resources, Apr 2022]

Drd1 Products (3)

mRNA	Protein	Name
NM_012546.3	NP_036678.3	D(1A) dopamine receptor
XM_006253599.4	XP_006253661.1	D(1A) dopamine receptor isoform X1
XM_006253600.4	XP_006253662.1	D(1A) dopamine receptor isoform X1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATPase binding	IPI IPI: Inferred from physical interaction	20623535	RGD
enables D3 dopamine receptor binding	IPI IPI: Inferred from physical interaction	14732731	RGD
enables G protein-coupled receptor activity	IDA IDA: Inferred from direct assay	11818555	RGD
enables G-protein alpha-subunit binding	IPI IPI: Inferred from physical interaction	15798088	RGD
enables angiotensin receptor binding	IPI IPI: Inferred from physical interaction	22193384	RGD
enables dopamine binding	IMP IMP: Inferred from mutant phenotype	27483345	RGD
enables dopamine neurotransmitter receptor activity, coupled via Gs	IDA IDA: Inferred from direct assay	11818555	RGD
enables heterocyclic compound binding	IPI IPI: Inferred from physical interaction	16855100	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	12122054	RGD
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	23328768	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	22843680	RGD
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	12408866	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in adenylate cyclase-activating dopamine receptor signaling pathway	IDA IDA: Inferred from direct assay	8702641	RGD
involved in adenylate cyclase-activating dopamine receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	12688394	RGD
involved in associative learning	IEP IEP: Inferred from expression pattern	23437091	RGD
involved in associative learning	IMP IMP: Inferred from mutant phenotype	15245880	RGD
involved in behavioral response to cocaine	IMP IMP: Inferred from mutant phenotype	16377433	RGD
involved in calcium-mediated signaling	IDA IDA: Inferred from direct assay	14983054	RGD
involved in cellular response to hypoxia	IEP IEP: Inferred from expression pattern	20969567	RGD
involved in cellular response to insulin stimulus	IEP IEP: Inferred from expression pattern	12707290	RGD
involved in eating behavior	IDA IDA: Inferred from direct assay	12944496	RGD
involved in grooming behavior	IDA IDA: Inferred from direct assay	12944496	RGD
involved in intracellular protein transport	IMP IMP: Inferred from mutant phenotype	16641250	RGD
involved in locomotory behavior	IMP IMP: Inferred from mutant phenotype	16377433	RGD
involved in negative regulation of cell migration	IMP IMP: Inferred from mutant phenotype	12688394	RGD
involved in negative regulation of cellular response to hypoxia	IMP IMP: Inferred from mutant phenotype	27638511	RGD
involved in negative regulation of circadian sleep/wake cycle, sleep	IDA IDA: Inferred from direct assay	12944496	RGD
involved in negative regulation of protein kinase activity	IMP IMP: Inferred from mutant phenotype	12688394	RGD
involved in negative regulation of synaptic transmission	IDA IDA: Inferred from direct assay	17314300	RGD
involved in operant conditioning	IMP IMP: Inferred from mutant phenotype	15245880	RGD
involved in orbitofrontal cortex development	IEP IEP: Inferred from expression pattern	22015925	RGD
involved in positive regulation of feeding behavior	IMP IMP: Inferred from mutant phenotype	11705777	RGD
involved in positive regulation of long-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	20377617	RGD
involved in positive regulation of membrane potential	IMP IMP: Inferred from mutant phenotype	18662324	RGD
involved in positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	26277342	RGD
involved in postsynaptic modulation of chemical synaptic transmission	EXP EXP: Inferred from Experiment	15175382	RGD
involved in postsynaptic modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	15175382	RGD
involved in regulation of monoatomic ion transport	IDA IDA: Inferred from direct assay	14983054	RGD
involved in regulation of vasoconstriction	IMP IMP: Inferred from mutant phenotype	15778266	RGD
involved in response to activity	IEP IEP: Inferred from expression pattern	19759268	RGD
involved in response to amino acid	IEP IEP: Inferred from expression pattern	17052844	RGD
involved in response to amphetamine	IEP IEP: Inferred from expression pattern	19145071	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	20534718	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	23873704	RGD
involved in response to food	IEP IEP: Inferred from expression pattern	20875839	RGD
involved in response to nicotine	IEP IEP: Inferred from expression pattern	23447334	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	20673846	RGD
involved in response to retinoic acid	IEP IEP: Inferred from expression pattern	15939542	RGD
involved in response to steroid hormone	IEP IEP: Inferred from expression pattern	18809391	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	15798088	RGD
involved in social behavior	IMP IMP: Inferred from mutant phenotype	21557291	RGD
involved in striatum development	IEP IEP: Inferred from expression pattern	22015925	RGD
involved in synapse assembly	IEP IEP: Inferred from expression pattern	10051231	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in axon	IDA IDA: Inferred from direct assay	17576511	RGD
located in axon terminus	IDA IDA: Inferred from direct assay	17576511	RGD
located in caveola	IDA IDA: Inferred from direct assay	15265765	RGD
located in cell surface	IDA IDA: Inferred from direct assay	27483345	RGD
located in dendrite	IDA IDA: Inferred from direct assay	16641250	RGD
located in dendritic shaft	IDA IDA: Inferred from direct assay	16228995	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	11818555	RGD
located in dendritic spine head	IDA IDA: Inferred from direct assay	21809413	RGD
located in dendritic spine neck	IDA IDA: Inferred from direct assay	21809413	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	18340460	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	17576511	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	18424554	RGD
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	18340460	RGD
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	18340460	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Drd1 Protein Structure

7tm_1

0
100
200
300
400
446 a.a.

Protein Preferred Names	Protein Names
D(1A) dopamine receptor	Dopamine-1A receptor dopamine receptor D1A

Related Diseases

Diseases	Alias
Gilles De La Tourette Syndrome	Tourette Syndrome Tourette Disorder GTS Ts Gilles De La Tourette'S Syndrome Motor-Verbal Tic Disorder Guinon'S Disease Psychogenic Tics Tourette'S Syndrome Chronic Motor And Vocal Tic Disorder Td Tourette'S Disease Combined Vocal And Multiple Motor Tic Disorder [De La Tourette] Combined Vocal And Multiple Motor Tic Disorder Tic De La Tourette
Bestiality	Zoophilia
Psychotic Disorder	Psychotic Disorders Mental Or Behavioural Disorder Psychotic Mental Disorders
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Substance Abuse	Substance-Related Disorders Substance Abuse Problem
Bruxism	Sleep Bruxism Sleep-Related Bruxism Bruxism - Teeth Grinding Grinding Teeth Sleep Related Bruxism Teeth Grinding Sleep Related Teeth Grinding
Huntington Disease	Huntington'S Disease Huntington Chorea HD Huntington'S Chorea Huntington Chronic Progressive Hereditary Chorea Juvenile Huntington Disease Chronic Progressive Chorea Chronic Progressive Hereditary Chorea Hc - [Huntington Chorea] Hereditary Chorea Progressive Hereditary Chorea
Drug Dependence
Cocaine Dependence
Panic Disorder	Panic Anxiety Syndrome Panic Panic Disorder 1 Episodic Paroxysmal Anxiety Disorder
Autoimmune Lymphoproliferative Syndrome, Type Iii	ALPS3 Autoimmune Lymphoproliferative Syndrome Type 3 Cvid9 Immunodeficiency, Common Variable, 9, Formerly Cvid9, Formerly Autoimmune Lymphoproliferative Syndrome Type Iii Common Variable Immunodeficiency 9 Autoimmune Lymphoproliferative Syndrome 3 Immunodeficiency, Common Variable, 9 Type 3 Autoimmune Lymphoproliferative Syndrome Immunodeficiency, Variable, Common, Type 9
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic
Impulse Control Disorder	Disruptive, Impulse Control, And Conduct Disorders
Cocaine Abuse	Cocaine-Related Disorders
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Obsessive-Compulsive Disorder	OCD Obsessive-Compulsive Disorder, Susceptibility To Anancastic Neurosis Obsessive Compulsive Disorder Anankastic Neurosis Obsessive-Compulsive Neurosis Obsessive Compulsive Behavior
Migraine With Or Without Aura 1	Migraine Migraine With Or Without Aura, Susceptibility To, 1 Migraine Disorder Migraine Variant Migraines Migraine Disorders Mgr1 Mgau Ma Migraine With Or Without Aura Classic Migraine Common Migraine Disorder, Migraine Headache Migraine Headache Migrainous Migraine Headache Migraine Syndrome Headache Including Migraine Migraine, Susceptibility To
Dystonia	Dystonic Disease Dystonic Disorder Dystonia Disorders Neuroleptic Dyskinesia
Heroin Dependence
Oppositional Defiant Disorder	Disorder Oppositional Defiance Behavioural Disorder Oppositional Defiance Disruptive Mood Dysregulation Disorder
Restless Legs Syndrome	Wed Willis-Ekbom Disease Restless Leg Syndrome Ekbom Syndrome Wittmaack-Ekbom Syndrome Willis Ekbom Disease Ekbom'S Syndrome Rls Restless Legs Restless Legs Syndrome, Susceptibility To
Alcohol Dependence	Alcoholism Alcohol Dependence, Susceptibility To Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against Alcohol Dependence, Protection Against Alcoholism, Susceptibility To Alcoholic Intoxication, Chronic Pharyngeal Neoplasms Chronic Alcoholism Dipsomania Alcohol Addiction Ethanol Dependence Chronic Ethanolism Chronic Alcoholic Disease Nos Alcoholic Disease Nos Alcoholic
Opiate Dependence	Opioid Dependence Opioid Addiction Opiate Addiction Opioid Type Dependence Opioid-Related Disorders Opium Dependence Narcotic Dependence Intravenous Narcotism Narcotism Nos Oral Narcotism Nos
Major Depressive Disorder	Seasonal Affective Disorder Unipolar Depression Depression MDD Depressive Disorder Unipolar Depression, Susceptibility To Major Depressive Disorder 1 Major Depressive Disorder, Response To Citalopram Therapy In Major Depressive Disorder 2 Winter Depression Single Major Depressive Episode Sad Clinical Depression Major Depression Depressive Syndrome Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment Seasonal Affective Disorder, Susceptibility To Recurrent Major Depression Affective Disorder, Seasonal Depression In A Seasonal Pattern Depression Seasonal Major Depressive Disorder With A Seasonal Pattern Seasonal Depression Seasonal Mood Disorder Mental Depression Recurrent Major Depressive Episodes
Bipolar Disorder	Bipolar Depression Manic Disorder Depression, Bipolar Bipolar Disorder Manic Phase Depressive-Manic Psych. Manic Bipolar Affective Disorder Manic Bipolar I Disorder Manic Depression Manic Depressive Disorder Mixed Bipolar Disorder Bipolar Affective Disorder Bipolar Affective Psychosis Bipolar Spectrum Disorder Manic Depressive Illness Depression Bipolar Bipolar Disorder, Mixed Major Affective Disorder Major Affective Disorder 1 Major Affective Disorder 2
Tobacco Addiction	Nicotine Dependence Tobacco Addiction, Susceptibility To Nicotine Addiction Tobacco Use Disorder Smoking Habit Nicotine Dependence, Protection Against Nicotine Addiction, Protection From Cigarette Habituation Cigarette Habituation, Susceptibility To Smoking Habit, Susceptibility To Nicotine Dependence, Susceptibility To Nicotine Addiction, Susceptibility To Addiction, Tobacco, Susceptibility To Compulsive Tobacco User Syndrome Tobacco Dependence Tobacco Dependence Syndrome Cigarette Addiction Cigarette Dependence Smoking Addiction Smokers Syndrome
Ewing Sarcoma	Neuroepithelioma Ewing'S Tumor Ewings Sarcoma Ewing'S Sarcoma Peripheral Neuroepithelioma Primitive Neuroectodermal Tumor ES Ewings Sarcoma-Primitive Neuroectodermal Tumor Localized Peripheral Primitive Neuroectodermal Tumor Peripheral Primitive Neuroectodermal Tumor Ewing Tumor Sarcoma, Ewing'S Extraosseous Ewing Tumor Askin Tumor Ewing'S Family Localized Tumor Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing Sarcoma Localized Ewing'S Sarcoma Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing'S Tumor Pnet Of Thoracopulmonary Region Ewing Family Of Tumors Tumor Of The Ewing Family Skeletal Ewing Sarcoma Osseous Ewing Sarcoma Ppnet Peripheral Pnet Extraskeletal Ewing Sarcoma Eoe Extraosseous Ewing Sarcoma Extraskeletal Ewing Tumor Esft Ewing Sarcoma Family Of Tumors Pne Pnet Pnet Of The Chest Wall Sarcoma, Ewing Neuroectodermal Tumors, Primitive, Peripheral Neuroectodermal Tumor, Primitive Disorder Of Eye Askin'S Tumor Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor Neuroepithelioma, Peripheral
Trichothiodystrophy 7, Nonphotosensitive	TTD7 Nonphotosensitive Trichothiodystrophy 7 Trichothiodystrophy 7, Non-Photosensitive
Pathological Gambling	Compulsive Gambling Gambling Gambling, Pathological Addiction Betting Addiction Gambling Betting Pathological Gambling Dependence
Attention Deficit-Hyperactivity Disorder	Attention Deficit Hyperactivity Disorder ADHD Attention Deficit Disorder Attention Deficit-Hyperactivity Disorder, Susceptibility To Attention Deficit Disorder With Hyperactivity Hyperkinetic Disorder Hyperactivity Of Childhood Attention-Deficit/Hyperactivity Disorder Add Addh Attention Deficit Attention Deficit Disorder Of Childhood With Hyperactivity Attention Deficit Disorder With Hyperactivity Syndrome Hyperkinetic Syndrome Attention-Deficit Hyperactivity Disorder Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type Disturbance Of Activity And Attention Disorder Of Activity And Attention Adhd - [Attention Deficit Hyperactivity Disorder] Hyperkinetic Disorders Disorder Of Activity And Attention With Hyperkinesia Attention Deficit Syndrome With Hyperactivity
Narcolepsy	Paroxysmal Sleep Gelineau Syndrome Narcoleptic Syndrome Narcolepsy-Cataplexy Syndrome Cataplexy And Narcolepsy Narcolepsy, Without Cataplexy Gelineau'S Syndrome Narcolepsy With Or Without Cataplexy Narcolepsy Nos
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Choreatic Disease	Chorea Hereditary Chorea
Tic Disorder	Tics Behavioral Tic
Mood Disorder	Mood Disorders Episodic Mood Disorder
Cholera	Vibrio Cholerae Infection Cholera - Vibrio Cholerae Cholera Due To Vibrio Cholerae Vibrio Cholerae Cholera Syndrome Asiatic Cholera Epidemic Cholera
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Substance Dependence
Schizophrenia 12	Sczd12 Schizophrenia Susceptibility Locus, Chromosome 1p-Related
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Anxiety	Anxiety Disorder Anxiety Disorders Anxiety State Anxieties Anxiety Neurosis
Brugada Syndrome 3	BRGDA3 Brugada Syndrome, Type 3
Cerebral Meningioma	Meningioma Of Cerebrum
Parkinsonism	Parkinsonism-Plus Idiopathic Parkinsonism Primary Parkinsonism Paralysis Agitans Syndrome Parkinsonian Syndrome Trembling Paralysis Paralysis Agitans Shaking Palsy Shaking Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03622	Ddr1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS03994	DRD1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS03995	Drd1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS03996	Drd1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Drd1	NCBI	NCBI:1812