MLS6585
MLS6585 is a selective D1 dopamine receptor (D1R) positive allosteric modulator that enhances Dopamine (HY-B0451)-stimulated G protein/β-arrestin signaling and affinity without intrinsic D1R agonist activity. MLS6585 is inactive at D2R, D3R, D4R, and β2-adrenergic receptors. MLS6585 partially restores signaling of loss-of-function DRD1 variants and enhances responses to multiple agonists.
For research use only. We do not sell to patients.
- CAS No.: 389080-71-1
- Formula: C19H23N3O2S
- Molecular Weight:357.47
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
D1 Receptor |
In Vitro
MLS6585 (50 µM; 90 min) is a low-micromolar-affinity orthosteric allosteric modulator of D1R in HEK293-D1R membranes, which increases dopamine affinity by approximately 7-fold and inhibits [3H]-SCH23390 binding by about 66% at 50 µM[1].
MLS6585 (0.1-100 µM; 90 min) is a positive allosteric modulator of dopamine-stimulated β-arrestin recruitment in CHO-K1 D1R cells, enhancing dopamine potency by approximately 7-8 fold and displaying low micromolar affinity (Kb 5.4 µM)[1].
MLS6585 (50 µM) enhances dopamine-induced D1R internalization in U2OS cells, increasing dopamine potency by 6-fold without increasing maximal internalization[1].
MLS6585 increases DA affinity at D1R in radioligand binding assays[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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CAS No. 389080-71-1
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Molecular Weight 357.47
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Formula C19H23N3O2S
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SMILES
O=C(N)C1=C(SC2=C1CCC(C2)C(C)(C)C)NC(=O)C=3C=CN=CC3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MLS6585 Related Classifications
HY-123828 Related Classifications
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