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Hspa8 - heat shock protein family A (Hsp70) member 8 Gene

Also Known as Hsc70

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 24468

Summary

Enables several functions, including A1 Adenosine Receptor binding activity; ATP hydrolysis activity; and adenyl ribonucleotide binding activity. Involved in several processes, including animal organ development; protein import; and protein-containing complex disassembly. Acts upstream of or within cellular protein complex disassembly. Located in several cellular components, including dendrite; polymeric cytoskeletal fiber; and vacuole. Part of messenger ribonucleoprotein complex. Is active in several cellular components, including glutamatergic synapse; glycinergic synapse; and postsynaptic density. Biomarker of Parkinson's disease; acute kidney failure; brain ischemia; disease of metabolism; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Parkinson's disease and renal hypertension. Orthologous to human HSPA8 (heat shock protein family A (HSP70) member 8). [provided by Alliance of Genome Resources, Apr 2022]

Hspa8 Products (1)

mRNA	Protein	Name
NM_024351.2	NP_077327.1	heat shock cognate 71 kDa protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables A1 adenosine receptor binding	IPI IPI: Inferred from physical interaction	10866672	RGD
enables ADP binding	IDA IDA: Inferred from direct assay	11133993	RGD
enables ATP binding	IDA IDA: Inferred from direct assay	11133993	RGD
enables ATP hydrolysis activity	IDA IDA: Inferred from direct assay	9528774	RGD
enables RNA binding	IDA IDA: Inferred from direct assay	23159318	RGD
enables clathrin-uncoating ATPase activity	IDA IDA: Inferred from direct assay	8363588	RGD
enables enzyme binding	IPI IPI: Inferred from physical interaction	21958194	RGD
enables peptide binding	IDA IDA: Inferred from direct assay	8363588	RGD
enables prostaglandin binding	IPI IPI: Inferred from physical interaction	21445266	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	8806721	RGD
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	11133993	RGD
enables unfolded protein binding	IMP IMP: Inferred from mutant phenotype	11133993	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in G1/S transition of mitotic cell cycle	IEP IEP: Inferred from expression pattern	10198213	RGD
involved in axo-dendritic transport	IEP IEP: Inferred from expression pattern	11933046	RGD
involved in cellular response to cadmium ion	IEP IEP: Inferred from expression pattern	9736451	RGD
involved in cellular response to heat	IEP IEP: Inferred from expression pattern	8955942	RGD
involved in cellular response to hydrogen peroxide	IEP IEP: Inferred from expression pattern	10329212	RGD
involved in cerebellum development	IEP IEP: Inferred from expression pattern	9764759	RGD
involved in chaperone-mediated autophagy	IDA IDA: Inferred from direct assay	18644871	RGD
acts upstream of or within chaperone-mediated autophagy	IGI IGI: Inferred from genetic interaction	18644871	RGD
involved in chaperone-mediated autophagy translocation complex disassembly	IDA IDA: Inferred from direct assay	18644871	RGD
involved in chaperone-mediated protein folding	IDA IDA: Inferred from direct assay	11133993	RGD
involved in clathrin coat disassembly	IDA IDA: Inferred from direct assay	8363588	RGD
involved in estrous cycle	IEP IEP: Inferred from expression pattern	9990085	RGD
involved in forebrain development	IEP IEP: Inferred from expression pattern	9878698	RGD
involved in kidney development	IEP IEP: Inferred from expression pattern	9764759	RGD
involved in maintenance of postsynaptic specialization structure	EXP EXP: Inferred from Experiment	21209184	RGD
involved in maintenance of postsynaptic specialization structure	IDA IDA: Inferred from direct assay	21209184	RGD
involved in maintenance of postsynaptic specialization structure	IMP IMP: Inferred from mutant phenotype	21209184	RGD
involved in negative regulation of cardiac muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	21958194	RGD
involved in positive regulation of T cell mediated cytotoxicity	IMP IMP: Inferred from mutant phenotype	8871636	RGD
involved in positive regulation of catalytic activity	IMP IMP: Inferred from mutant phenotype	21958194	RGD
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	8734434	RGD
involved in positive regulation of lysosomal membrane permeability	IMP IMP: Inferred from mutant phenotype	9038169	RGD
involved in positive regulation of phagocytosis	IMP IMP: Inferred from mutant phenotype	9886410	RGD
involved in positive regulation of protein refolding	IDA IDA: Inferred from direct assay	11360998	RGD
involved in positive regulation of proteolysis	IDA IDA: Inferred from direct assay	9987077	RGD
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	8420978	RGD
involved in protein import into nucleus	IMP IMP: Inferred from mutant phenotype	8892974	RGD
involved in protein transmembrane import into intracellular organelle	IEP IEP: Inferred from expression pattern	9038169	RGD
acts upstream of or within protein-containing complex disassembly	IMP IMP: Inferred from mutant phenotype	18644871	RGD
involved in regulation of protein complex stability	IDA IDA: Inferred from direct assay	18644871	RGD
involved in response to activity	IEP IEP: Inferred from expression pattern	10606824	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	9990085	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	12170112	RGD
involved in response to nickel cation	IEP IEP: Inferred from expression pattern	15736156	RGD
involved in response to odorant	IEP IEP: Inferred from expression pattern	11268007	RGD
involved in response to progesterone	IEP IEP: Inferred from expression pattern	9990085	RGD
involved in response to starvation	IEP IEP: Inferred from expression pattern	9038169	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	10425221	RGD
involved in skeletal muscle tissue development	IEP IEP: Inferred from expression pattern	12909603	RGD
involved in slow axonal transport	IEP IEP: Inferred from expression pattern	11933046	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in asymmetric synapse	IDA IDA: Inferred from direct assay	11230095	RGD
located in autophagosome	IDA IDA: Inferred from direct assay	20392947	RGD
located in axon	IDA IDA: Inferred from direct assay	9878698	RGD
located in cell surface	IDA IDA: Inferred from direct assay	8228242	RGD
located in dendrite	IDA IDA: Inferred from direct assay	9878698	RGD
located in dendritic shaft	IDA IDA: Inferred from direct assay	11230095	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	11230095	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	9878698	RGD
is active in glycinergic synapse	EXP EXP: Inferred from Experiment	21209184	RGD
is active in glycinergic synapse	IDA IDA: Inferred from direct assay	21209184	RGD
is active in glycinergic synapse	IMP IMP: Inferred from mutant phenotype	21209184	RGD
located in intermediate filament	IDA IDA: Inferred from direct assay	7721954	RGD
located in lysosomal matrix	IDA IDA: Inferred from direct assay	9038169	RGD
located in lysosomal membrane	IDA IDA: Inferred from direct assay	9038169	RGD
located in microtubule	IDA IDA: Inferred from direct assay	2527848	RGD
located in neuron spine	IDA IDA: Inferred from direct assay	9878698	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	9878698	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	11230095	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	10549657	RGD
located in photoreceptor inner segment	IDA IDA: Inferred from direct assay	10549657	RGD
is active in postsynapse	IDA IDA: Inferred from direct assay	9878698	RGD
is active in postsynaptic density	IDA IDA: Inferred from direct assay	9878698	RGD
located in postsynaptic density	IDA IDA: Inferred from direct assay	9878698	RGD
is active in presynapse	IDA IDA: Inferred from direct assay	9878698	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	9528774	RGD
located in synaptic vesicle	IDA IDA: Inferred from direct assay	19457116	RGD
located in terminal bouton	IDA IDA: Inferred from direct assay	9878698	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
heat shock cognate 71 kDa protein	Heat shock cognate protein 70 heat shock 70kD protein 8 heat shock 70kDa protein 8 heat shock protein 8 heat shock protein A8

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-111002	Displurigen	Inhibitor	98.48%	Unkown
HY-RS06436	HSPA8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17202	Hspa8 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23654	Hspa8 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hspa8	NCBI	NCBI:3312