HSPA8 - heat shock protein family A (Hsp70) member 8 Gene

Also Known as LAP1; HSC54; HSC70; HSC71; HSP71; HSP73; LAP-1; NIP71; HEL-33; HSPA10; HEL-S-72p

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3312

About HSPA8

Cytogenetic location: 11q24.1 Genomic coordinates (GRCh38): 11:123,057,489-123,062,462 (from NCBI)

This gene has 24 transcripts (splice variants), 316 orthologues and 13 paralogues. Ubiquitous expression in brain (RPKM 443.0), kidney (RPKM 352.5) and 25 other tissues.

Summary

This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

HSPA8 Products (2)

mRNA	Protein	Name
NM_006597.6	NP_006588.1	heat shock cognate 71 kDa protein isoform 1
NM_153201.4	NP_694881.1	heat shock cognate 71 kDa protein isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP binding	IDA IDA: Inferred from direct assay	23921388	GOA
enables ATP-dependent protein disaggregase activity	IDA IDA: Inferred from direct assay	23921388	GOA
enables C3HC4-type RING finger domain binding	IPI IPI: Inferred from physical interaction	25281747	GOA
enables G protein-coupled receptor binding	IPI IPI: Inferred from physical interaction	12150907	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	23921388	GOA
enables heat shock protein binding	IPI IPI: Inferred from physical interaction	17182002	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9305631	GOA
enables protein-folding chaperone binding	IPI IPI: Inferred from physical interaction	16207813	GOA
enables protein-macromolecule adaptor activity	IDA IDA: Inferred from direct assay	2799391	GOA
enables protein-macromolecule adaptor activity	IPI IPI: Inferred from physical interaction	16207813	GOA
enables receptor ligand activity	IDA IDA: Inferred from direct assay	17785435	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	12150907	GOA
enables unfolded protein binding	IDA IDA: Inferred from direct assay	21231916	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in ATP metabolic process	IDA IDA: Inferred from direct assay	23921388	GOA
involved in clathrin coat disassembly	IDA IDA: Inferred from direct assay	8524399	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	10722728	GOA
involved in negative regulation of NLRP3 inflammasome complex assembly	IDA IDA: Inferred from direct assay	36586411	GOA
involved in negative regulation of supramolecular fiber organization	IDA IDA: Inferred from direct assay	23921388	GOA
involved in positive regulation of cell migration	IDA IDA: Inferred from direct assay	17785435	GOA
involved in protein refolding	IDA IDA: Inferred from direct assay	21231916	GOA
involved in protein targeting to lysosome involved in chaperone-mediated autophagy	IDA IDA: Inferred from direct assay	11559757	GOA
involved in protein targeting to lysosome involved in chaperone-mediated autophagy	IMP IMP: Inferred from mutant phenotype	26212789	GOA
involved in regulation of protein stability	IMP IMP: Inferred from mutant phenotype	26212789	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of Prp19 complex	IDA IDA: Inferred from direct assay	20176811	GOA
part of Prp19 complex	IPI IPI: Inferred from physical interaction	20176811	GOA
located in cytosol	IDA IDA: Inferred from direct assay	21231916	GOA
located in extracellular exosome	IDA IDA: Inferred from direct assay	19028452	GOA
is active in extracellular space	IDA IDA: Inferred from direct assay	16502470	GOA
is active in lysosomal membrane	IDA IDA: Inferred from direct assay	11559757	GOA
located in nucleus	IDA IDA: Inferred from direct assay	20176811	GOA
part of protein folding chaperone complex	IPI IPI: Inferred from physical interaction	16207813	GOA
part of ribonucleoprotein complex	IDA IDA: Inferred from direct assay	17289661	GOA
part of spliceosomal complex	IPI IPI: Inferred from physical interaction	20176811	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HSPA8 Protein Structure

HSP70

0
100
200
300
400
500
600
646 a.a.

Protein Preferred Names	Protein Names
heat shock cognate 71 kDa protein	LPS-associated protein 1

HSPA8 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	HSPA8	P11142	BAG1	Homo sapiens	Q99933	Peptide Array	19800331
Intra	HSPA8	P11142	P01308-PRO_0000015820	Homo sapiens	P01308-PRO_0000015820	NMR	29764935
Intra	HSPA8	P11142	TRIM38	Homo sapiens	O00635	Y2H Array	32296183
Intra	HSPA8	P11142	TRIM38	Homo sapiens	O00635	Y2H Prey Pooling	25416956
Intra	HSPA8	P11142	TRIM38	Homo sapiens	O00635	Validated Y2H	25416956
Intra	HSPA8	P11142	TRIM38	Homo sapiens	O00635	Y2H Prey Pooling	32296183
Intra	HSPA8	P11142	SF3A2	Homo sapiens	Q15428	Anti Tag CoIP	33961781
Intra	HSPA8	P11142	SF3A2	Homo sapiens	Q15428	Anti Tag CoIP	28514442
Intra	HSPA8	P11142	BAG4	Homo sapiens	O95429	Y2H Prey Pooling	32296183
Intra	HSPA8	P11142	BAG4	Homo sapiens	O95429	Y2H Array	32296183
Intra	HSPA8	P11142	BAG4	Homo sapiens	O95429	Pull Down	29568061
Intra	HSPA8	P11142	EGFR	Homo sapiens	P00533	Lumier	24658140
Intra	HSPA8	P11142	EGFR	Homo sapiens	P00533	Ub Reconstruction	24658140
Intra	HSPA8	P11142	HLA-H	Homo sapiens	P01893	FPS	29764935
Intra	HSPA8	P11142	HLA-H	Homo sapiens	P01893	NMR	29764935
Intra	HSPA8	P11142	BAG2	Homo sapiens	O95816	Pull Down	29568061
Intra	HSPA8	P11142	BAG2	Homo sapiens	O95816	Anti Tag CoIP	33961781
Intra	HSPA8	P11142	BAG2	Homo sapiens	O95816	Y2H	22365833
Intra	HSPA8	P11142	BAG2	Homo sapiens	O95816	BioID	29568061
Intra	HSPA8	P11142	HSPBP1	Homo sapiens	Q9NZL4	Y2H Prey Pooling	25416956
Intra	HSPA8	P11142	HSPBP1	Homo sapiens	Q9NZL4	Anti Tag CoIP	35271311
Intra	HSPA8	P11142	HSPBP1	Homo sapiens	Q9NZL4	BioID	29568061
Intra	HSPA8	P11142	HSPBP1	Homo sapiens	Q9NZL4	Validated Y2H	25416956
Intra	HSPA8	P11142	HSPBP1	Homo sapiens	Q9NZL4	Pull Down	29568061
Intra	HSPA8	P11142	HSPBP1	Homo sapiens	Q9NZL4	Anti Tag CoIP	33961781
Intra	HSPA8	P11142	HSPBP1	Homo sapiens	Q9NZL4	Anti Tag CoIP	28514442
Intra	HSPA8	P11142	HSPBP1	Homo sapiens	Q9NZL4	Y2H Array	25416956
Intra	HSPA8	P11142	HSPA4	Homo sapiens	P34932	BioID	29568061
Intra	HSPA8	P11142	HSPA4	Homo sapiens	P34932	Crosslink	30021884
Intra	HSPA8	P11142	HSPA4	Homo sapiens	P34932	Anti Tag CoIP	33961781
Intra	HSPA8	P11142	HSPA4	Homo sapiens	P34932	Pull Down	29568061
Intra	HSPA8	P11142	STUB1	Homo sapiens	Q9UNE7	Filter Binding	16275660
Intra	HSPA8	P11142	STUB1	Homo sapiens	Q9UNE7	Pull Down	16275660
Intra	HSPA8	P11142	STUB1	Homo sapiens	Q9UNE7	BioID	29568061
Intra	HSPA8	P11142	STUB1	Homo sapiens	Q9UNE7	Pull Down	29568061
Intra	HSPA8	P11142	STUB1	Homo sapiens	Q9UNE7	ITC	20618441
Intra	HSPA8	P11142	MAPT	Homo sapiens	P10636	Anti Tag CoIP	33961781
Intra	HSPA8	P11142	MAPT	Homo sapiens	P10636	FPS	29764935
Intra	HSPA8	P11142	MAPT	Homo sapiens	P10636	NMR	29764935
Intra	HSPA8	P11142	LDHA	Homo sapiens	P00338	Pull Down	23523103
Intra	HSPA8	P11142	AICDA	Homo sapiens	Q9GZX7	Anti Tag CoIP	22085931
Intra	HSPA8	P11142	ESRP2	Homo sapiens	Q9H6T0	Anti Tag CoIP	33961781
Intra	HSPA8	P11142	NCF1	Homo sapiens	P14598	Anti Tag CoIP	25910212
Intra	HSPA8	P11142	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	HSPA8	P11142	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	HSPA8	P11142	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	HSPA8	P11142	LRRK2	Homo sapiens	Q5S007	Anti Tag CoIP	23455607
Intra	HSPA8	P11142	ATP13A2	Homo sapiens	Q9NQ11	Ub Reconstruction	22645275
Intra	HSPA8	P11142	EIF2AK1	Homo sapiens	Q9BQI3	Anti Bait CoIP	31273097
Intra	HSPA8	P11142	EIF2AK1	Homo sapiens	Q9BQI3	Pull Down	29568061
Intra	HSPA8	P11142	ARRB2	Homo sapiens	P32121	Anti Tag CoIP	17620599
Intra	HSPA8	P11142	GAK	Homo sapiens	O14976	Anti Tag CoIP	33961781
Intra	HSPA8	P11142	GAK	Homo sapiens	O14976	Anti Tag CoIP	24510904
Intra	HSPA8	P11142	GAK	Homo sapiens	O14976	Anti Tag CoIP	28514442
Intra	HSPA8	P11142	GAK	Homo sapiens	O14976	BioID	29568061
Intra	HSPA8	P11142	ARRB1	Homo sapiens	P49407	Anti Tag CoIP	17620599
Intra	HSPA8	P11142	MAPT	Homo sapiens	P10636-6	FPS	29764935
Intra	HSPA8	P11142	MAPT	Homo sapiens	P10636-6	NMR	29764935
Intra	HSPA8	P11142	JUN	Homo sapiens	P05412	Display Tech	20195357
Intra	HSPA8	P11142	ATXN1	Homo sapiens	P54253	Validated Y2H	32814053
Intra	HSPA8	P11142	ATXN1	Homo sapiens	P54253	Y2H Pooling	32814053
Intra	HSPA8	P11142	ATXN1	Homo sapiens	P54253	Y2H Array	32814053
Intra	HSPA8	P11142	STXBP1	Homo sapiens	P61764	Anti Tag CoIP	25910212
Cross	HSPA8	P11142	EBNA-LP	Epstein-Barr virus	Q8AZK7	Anti Bait CoIP	18457437
Cross	HSPA8	P11142	M	Influenza A virus	P03485	Filter Binding	17022977
Cross	HSPA8	P11142	M	Influenza A virus	P03485	Anti Bait CoIP	17022977
Cross	HSPA8	P11142	Q99IB8-PRO_0000045603	Hepatitis C virus	Q99IB8-PRO_0000045603	Pull Down	24136289
Cross	HSPA8	P11142	Q99IB8-PRO_0000045603	Hepatitis C virus	Q99IB8-PRO_0000045603	Split-Luc	24136289
Cross	HSPA8	P11142	Q99IB8-PRO_0000045603	Hepatitis C virus	Q99IB8-PRO_0000045603	Y2H	24136289

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant HSPA8 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73915	HSPA8/HSC70 Protein, Human (His, Solution)	P11142-1 (M1-D646)	≥ 90%, as determined by reducing SDS-PAGE.

HSPA8 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80708	HSC70 Antibody (YA360)	WB, IHC-P, IP	Human, Mouse, Rat, Hamster
HY-P80708A	HSC70 Antibody (YA360)(PBS only)	WB, IHC-P, IP	Human, Mouse, Rat, Hamster
HY-P85704	HSC70 Antibody (YA5396)	IHC-P, WB	Human, Mouse, Rat
HY-P86734	HSC70 Antibody (YA6426)	WB, IHC-P, IHC-F, IF-Tissue	Human, Mouse, Rat
HY-P86734A	HSC70 Antibody (YA6426)(PBS only)	WB, IHC-P, IHC-F, IF-Tissue	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Auditory System Disease	Ear Diseases Ear And Mastoid Disease
Borna Disease	Enzootic Encephalomyelitis
Ischemia	Acute Coronary Syndrome
Arthritis	Inflammatory Joint Disease Inflammatory Disorder Of Joint
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Sensorineural Hearing Loss	Sensory Hearing Loss Sensorineural Deafness Sensorineural Hearing Loss Disorder Hearing Loss, Sensorineural Central Hearing Loss High Frequency Deafness High Frequency Hearing Loss High-Frequency Hearing Loss Perceptive Deafness Perceptive Hearing Loss Perceptive Hearing Loss Or Deafness Hearing Loss Sensorineural Deafness Sensorineural Hearing Loss High-Frequency Hearing Loss, Central Hearing Loss, High-Frequency
Axonal Neuropathy
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Heart Disease	Heart Failure Congenital Heart Disease Heart Diseases Congenital Heart Defects Congenital Heart Defect Heart Malformation Congenital Anomaly Of Heart Heart Defect Heart-Congenital Defect Congenital Heart Disorder Heart Defects Congenital Heart Defects, Congenital Heart Defects Heart Disease, Congenital Disease, Heart, Congenital Congestive Heart Failure
Meniere Disease	Meniere'S Disease Otogenic Vertigo Ménière Disease Ménière'S Disease Mnire'S Vertigo Auditory Vertigo Aural Vertigo Meniere'S Syndrome Ménière'S Vertigo Primary Endolymphatic Hydrops Menieres Disease Vertigo, Aural Labyrinth Hydrops Labyrinthine Hydrops Labyrinthine Vertigo Ménière Syndrome Ménière Vertigo Idiopathic Endolymphatic Hydrops
Muscular Atrophy	Muscle Wasting Amyotrophia Wasting - Muscle Skeletal Muscle Atrophy
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Complement Component 7 Deficiency	C7 Deficiency C7D
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Muscular Dystrophy	Muscular Dystrophies Congenital Md Congenital Muscular Dystrophy Cmd Mdc Dystrophy, Muscular Gower'S Muscular Dystrophy Progressive Musclular Dystrophy Pseudohypertrophic Atrophy Pseudohypertrophic Muscle Paralysis Pseudohypertrophic Muscular Atrophy Pseudohypertrophic Muscular Dystrophy Pseudohypertrophic Paralysis Pseudomuscular Hypertrophy
Gastric Cancer	Stomach Cancer Gastric Carcinoma Stomach Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Dystonia	Dystonic Disease Dystonic Disorder Dystonia Disorders Neuroleptic Dyskinesia
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Stroke, Ischemic	Cerebral Infarction Stroke Ischemic Stroke Cerebrovascular Accident Cerebral Infarction, Susceptibility To Stroke, Ischemic, Susceptibility To Cerebral Infarct Ischemic Stroke, Susceptibility To Stroke, Susceptibility To Cva - Cerebral Infarction ISCHSTR Ischemic Cerebrovascular Accident
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Leukemia, Chronic Myeloid	Chronic Myeloid Leukemia Chronic Myelogenous Leukemia CML Chronic Granulocytic Leukemia Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib Chronic Myeloid Leukaemia Chronic Granulocytic Leukaemia Chronic Myelogenous Leukaemia Myeloid Leukemia, Chronic Leukemia, Chronic Myelogenous Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic Cml - Chronic Myelogenous Leukemia Cgl Chronic Myelocytic Leukemia Leukemia, Chronic Myeloid, Atypical ACML Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative Myeloid Leukemia Chronic Leukemia, Myeloid, Chronic Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative Cml- [Chronic Myeloid Leukaemia] Cgl - [Chronic Granulocytic Leukaemia] Chronic Myelocytic Leukaemia
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Lipoprotein Quantitative Trait Locus	Coronary Artery Disease Coronary Artery Anomaly Coronary Artery Disease, Susceptibility To Myocardial Ischemia Congenital Anomaly Of Coronary Artery Coronary Arteriosclerosis Coronary Disease Coronary Heart Disease Coronary Artery Disorder LPAQTL Lpa Deficiency, Congenital Coronary Artery Abnormality Coronary Artery Anomaly, Congenital Chd Coronary Syndrome Congenital Malformations Of Coronary Vessels Malformation Of Coronary Vessels Congenital Coronary Artery Anomaly Congenital Coronary Artery Deformity Congenital Coronary Artery Disorder Abnormal Coronary Artery Congenital Coronary Artery Malposition Congenital Coronary Disease Congenital Anomaly Of Coronary Arteries
Pick Disease Of Brain	Pick Disease Pick'S Disease Pick Disease Of The Brain Lobar Atrophy Of Brain Dementia With Lobar Atrophy And Neuronal Cytoplasmic Inclusions Behavioral Variant Of Frontotemporal Dementia Dementia In Pick'S Disease Lobar Atrophy Of The Brain Bvftd Bv-Ftd PIDB Picks Disease
Neuronal Ceroid Lipofuscinosis	Hereditary Ceroid Lipofuscinosis Batten Disease Ncl Neuronal Ceroid-Lipofuscinoses Lipofuscinosis, Ceroid, Neuronal Juvenile Neuronal Ceroid Lipofuscinosis Cerebromacular Dystrophy Cerebromacular Degeneration Ceroid-Lipofuscinosis Ncl - [Neuronal Ceroid Lipofuscinosis] Amaurotic Familial Idiocy Amaurotic Idiocy Amaurotic Idiot Neuronal Lipofuscinosis Pigmentary Retinal Lipoid Neuronal Heredodegeneration
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-111002	Displurigen	Inhibitor	98.48%	Unkown
HY-RS06436	HSPA8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17202	Hspa8 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23654	Hspa8 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	HSPA8	VGNC	VGNC:82045
Canis familiaris	HSPA8	VGNC	VGNC:59028
Rattus norvegicus	HSPA8	RGD	RGD:621725
Bos taurus	HSPA8	VGNC	VGNC:54632
Macaca mulatta	HSPA8	VGNC	VGNC:101093
Mus musculus	HSPA8	MGD	MGI:105384
Others	HSPA8	NCBI