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ITGB1 - Itgb1 integrin subunit beta 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 24511

Summary

Enables several functions, including cytoskeletal protein binding activity; enzyme binding activity; and fibronectin binding activity. Involved in several processes, including bicellular tight junction assembly; regulation of cell projection organization; and regulation of neuron differentiation. Located in several cellular components, including acrosomal vesicle; focal adhesion; and hemidesmosome. Part of Integrin alpha3-beta1 complex and Integrin alpha9-beta1 complex. Is active in glutamatergic synapse. Is integral component of postsynaptic membrane. Used to study hydrocephalus and myocardial infarction. Biomarker of glomerulonephritis. Orthologous to human ITGB1 (Integrin subunit beta 1). [provided by Alliance of Genome Resources, Apr 2022]

ITGB1 Products (1)

mRNA	Protein	Name
NM_017022.2	NP_058718.2	integrin beta-1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables actin binding	IDA IDA: Inferred from direct assay	16935300	RGD
enables alpha-actinin binding	IDA IDA: Inferred from direct assay	16935300	RGD
enables collagen binding	IDA IDA: Inferred from direct assay	1835909	RGD
enables fibronectin binding	IDA IDA: Inferred from direct assay	1835909	RGD
enables integrin binding	IMP IMP: Inferred from mutant phenotype	17118629	RGD
enables integrin binding	IPI IPI: Inferred from physical interaction	2223092	RGD
enables kinase binding	IPI IPI: Inferred from physical interaction	16935300	RGD
enables laminin binding	IDA IDA: Inferred from direct assay	1835909	RGD
enables laminin binding	IMP IMP: Inferred from mutant phenotype	18635166	RGD
enables protease binding	IPI IPI: Inferred from physical interaction	19027888	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	8020590	RGD
enables protein domain specific binding	IDA IDA: Inferred from direct assay	18658130	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	11133699	RGD
enables protein-containing complex binding	IMP IMP: Inferred from mutant phenotype	17118629	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	2223092	RGD
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	18465789	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in bicellular tight junction assembly	IMP IMP: Inferred from mutant phenotype	18579774	RGD
involved in cell adhesion mediated by integrin	IGI IGI: Inferred from genetic interaction	20091784	RGD
involved in cell projection organization	IMP IMP: Inferred from mutant phenotype	20091784	RGD
involved in cellular response to ionizing radiation	IEP IEP: Inferred from expression pattern	19714308	RGD
involved in cellular response to mechanical stimulus	IEP IEP: Inferred from expression pattern	19720043	RGD
involved in cellular response to vitamin D	IEP IEP: Inferred from expression pattern	20304064	RGD
involved in establishment of Sertoli cell barrier	IEP IEP: Inferred from expression pattern	22872576	RGD
involved in lamellipodium assembly	IMP IMP: Inferred from mutant phenotype	20091784	RGD
involved in maintenance of postsynaptic specialization structure	EXP EXP: Inferred from Experiment	20935643	RGD
involved in maintenance of postsynaptic specialization structure	IDA IDA: Inferred from direct assay	20935643	RGD
involved in maternal process involved in female pregnancy	IEP IEP: Inferred from expression pattern	20353731	RGD
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	28367125	RGD
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	18658130	RGD
involved in negative regulation of cell projection organization	IMP IMP: Inferred from mutant phenotype	20039268	RGD
involved in negative regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	18658130	RGD
involved in phagocytosis	IMP IMP: Inferred from mutant phenotype	17410128	RGD
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	15466886	RGD
involved in positive regulation of cell-substrate adhesion	IMP IMP: Inferred from mutant phenotype	18167060	RGD
involved in positive regulation of endocytosis	IMP IMP: Inferred from mutant phenotype	18577581	RGD
involved in positive regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	18658130	RGD
involved in positive regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	14564503	RGD
involved in positive regulation of peptidyl-tyrosine phosphorylation	IMP IMP: Inferred from mutant phenotype	18465789	RGD
involved in protein transport within lipid bilayer	IMP IMP: Inferred from mutant phenotype	19420267	RGD
involved in regulation of G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	17157995	RGD
involved in regulation of postsynaptic neurotransmitter receptor diffusion trapping	EXP EXP: Inferred from Experiment	20935643	RGD
involved in regulation of postsynaptic neurotransmitter receptor diffusion trapping	IDA IDA: Inferred from direct assay	20935643	RGD
involved in response to activity	IEP IEP: Inferred from expression pattern	18378961	RGD
involved in response to gonadotropin	IEP IEP: Inferred from expression pattern	20189708	RGD
involved in response to nutrient levels	IEP IEP: Inferred from expression pattern	20200130	RGD
involved in response to transforming growth factor beta	IEP IEP: Inferred from expression pattern	18378961	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	20368265	RGD
involved in tissue homeostasis	IMP IMP: Inferred from mutant phenotype	17118629	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in acrosomal vesicle	IDA IDA: Inferred from direct assay	9202984	RGD
located in adherens junction	IDA IDA: Inferred from direct assay	18579774	RGD
located in basement membrane	IDA IDA: Inferred from direct assay	9202984	RGD
located in cell surface	IDA IDA: Inferred from direct assay	19705458	RGD
located in cell-cell junction	IDA IDA: Inferred from direct assay	11133699	RGD
located in focal adhesion	IDA IDA: Inferred from direct assay	17157995	RGD
located in glial cell projection	IDA IDA: Inferred from direct assay	20091784	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	22973009	RGD
is active in glycinergic synapse	EXP EXP: Inferred from Experiment	20935643	RGD
is active in glycinergic synapse	IDA IDA: Inferred from direct assay	20935643	RGD
located in hemidesmosome	IDA IDA: Inferred from direct assay	18579774	RGD
part of integrin alpha3-beta1 complex	IDA IDA: Inferred from direct assay	1835909	RGD
part of integrin alpha9-beta1 complex	IDA IDA: Inferred from direct assay	8020590	RGD
part of integrin complex	IDA IDA: Inferred from direct assay	17157995	RGD
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	22973009	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
integrin beta-1	VLA-4 subunit beta beta OL beta oligodendroglia collagen alpha-1(I) chain-like fibronectin receptor subunit beta integrin VLA-4 subunit beta integrin beta 1 (fibronectin receptor beta)

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P990643	OS-2966	Inhibitor	99.62%	Phase 1

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06963	ITGB1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16668	Itgb1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-E70297	N-Acetylglucosaminyltransferase IVa		/	Unkown
HY-RS06964	ITGB1BP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23103	Itgb1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P992055	Anti-ITGB1 Antibody		96.16%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	ITGB1	NCBI	NCBI:3688