Nf1 - neurofibromin 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24592

Summary

Enables microtubule binding activity and syndecan binding activity. Involved in several processes, including Schwann cell differentiation; cellular response to dexamethasone stimulus; and cellular response to nerve growth factor stimulus. Located in several cellular components, including axon; dendrite; and postsynaptic density. Part of protein-containing complex. Biomarker of sciatic neuropathy and transient cerebral ischemia. Human ortholog(s) of this gene implicated in autistic disorder; hematologic Cancer (multiple); nervous system Cancer (multiple); neurofibromatosis 1; and neurofibromatosis-Noonan syndrome. Orthologous to human NF1 (neurofibromin 1). [provided by Alliance of Genome Resources, Apr 2022]

Nf1 Products (1)

mRNA Protein Name
NM_012609.1 NP_036741.1 neurofibromin
Protein Preferred Names Protein Names

neurofibromin

  • Neurofibromatosis type 1

  • neurofibromatosis 1

  • neurofibromatosis-related protein NF-1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-W273690 Pentifylline Inhibitor 99.23% Phase 4
HY-158115 NST-628 Inhibitor 99.35% Phase 1

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-156872 MTX-216 / Unkown
HY-RS09233 NF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-113821 1-Naphthyl phosphate potassium salt Inhibitor 99.86% Unkown
HY-120614 BMS-186511 Inhibitor / Unkown
HY-RS17398 Nf1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23853 Nf1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nf1 NCBI NCBI:4763