Sod2 - superoxide dismutase 2 Gene

Also Known as MnSOD

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24787

Summary

Enables several functions, including identical protein binding activity; manganese ion binding activity; and superoxide dismutase activity. Involved in several processes, including hydrogen peroxide biosynthetic process; negative regulation of membrane hyperpolarization; and positive regulation of hydrogen peroxide biosynthetic process. Located in mitochondrial nucleoid. Used to study esophagus adenocarcinoma; hypertension; intestinal disease; and myocardial infarction. Biomarker of several diseases, including adult respiratory distress syndrome; artery disease (multiple); bladder neck obstruction; congenital diaphragmatic hernia; and hyperhomocysteinemia. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); lipid storage disease (multiple); liver disease (multiple); and optic nerve disease (multiple). Orthologous to human SOD2 (superoxide dismutase 2). [provided by Alliance of Genome Resources, Apr 2022]

Sod2 Products (1)

mRNA Protein Name
NM_017051.2 NP_058747.1 superoxide dismutase [Mn], mitochondrial precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
19228881 RGD
enables enzyme binding IPI
IPI: Inferred from physical interaction
24505357 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
19384983 RGD
enables manganese ion binding IDA
IDA: Inferred from direct assay
19384983 RGD
enables oxygen binding IDA
IDA: Inferred from direct assay
12107766 RGD
enables superoxide dismutase activity IDA
IDA: Inferred from direct assay
12107766 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to ethanol IEP
IEP: Inferred from expression pattern
19703426 RGD
involved in hydrogen peroxide biosynthetic process IDA
IDA: Inferred from direct assay
15642720 RGD
involved in hydrogen peroxide metabolic process IMP
IMP: Inferred from mutant phenotype
16716903 RGD
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
11961082 RGD
involved in negative regulation of membrane hyperpolarization IMP
IMP: Inferred from mutant phenotype
20529999 RGD
involved in positive regulation of hydrogen peroxide biosynthetic process IMP
IMP: Inferred from mutant phenotype
20529999 RGD
involved in removal of superoxide radicals IDA
IDA: Inferred from direct assay
12107766 RGD
involved in response to L-ascorbic acid IEP
IEP: Inferred from expression pattern
20122981 RGD
involved in response to activity IEP
IEP: Inferred from expression pattern
19297546 RGD
involved in response to cadmium ion IEP
IEP: Inferred from expression pattern
20107868 RGD
involved in response to electrical stimulus IEP
IEP: Inferred from expression pattern
17962976 RGD
involved in response to hydrogen peroxide IEP
IEP: Inferred from expression pattern
19917063 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
16911942 RGD
involved in response to immobilization stress IEP
IEP: Inferred from expression pattern
20020182 RGD
involved in response to isolation stress IEP
IEP: Inferred from expression pattern
20020182 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
17804075 RGD
involved in response to magnetism IEP
IEP: Inferred from expression pattern
20037191 RGD
involved in response to manganese ion IEP
IEP: Inferred from expression pattern
17920449 RGD
involved in response to nutrient levels IDA
IDA: Inferred from direct assay
12067840 RGD
involved in response to oxidative stress IEP
IEP: Inferred from expression pattern
15485085 RGD
involved in response to selenium ion IEP
IEP: Inferred from expression pattern
17804075 RGD
involved in response to silicon dioxide IEP
IEP: Inferred from expression pattern
17575405 RGD
involved in response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
15959853 RGD
involved in response to zinc ion IEP
IEP: Inferred from expression pattern
20128680 RGD
Cellular Component GO Annotation Evidence References Source
located in mitochondrial nucleoid IDA
IDA: Inferred from direct assay
19228881 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

superoxide dismutase [Mn], mitochondrial

  • Superoxide dimutase 2, mitochondrial

  • manganese superoxide dismutase

  • mitochondrial superoxide dismutase 2

  • superoxide dismutase 2, mitochondrial

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (15)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-134476 NF-κΒ activator 1 Activator 99.59% Unkown
HY-134477 NF-κΒ activator 2 Activator 99.76% Unkown
HY-N7700A Guluronic acid sodium Inhibitor 98.0% Unkown
HY-W014940 Ethylene glycol dimethacrylate 99.52% Unkown
HY-158162 SIRT3 activator 1 Activator 98.14% Unkown
HY-175352 Nurr1 agonist 14 99.42% Unkown
HY-N7700 Guluronic acid Inhibitor 98.90% Unkown
HY-RS13560 SOD2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W073128 Perfluorotetradecanoic acid 98.0% Unkown
HY-W248590 IR-775 chloride ≥98.0% Unkown
HY-179151 CDK4/6-IN-26 / Unkown
HY-182446 SRI-22818 Activator / Unkown
HY-181588 NR4A agonist-2 Agonist / Unkown
HY-RS16939 Sod2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23382 Sod2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sod2 NCBI NCBI:6648