Chm - CHM Rab escort protein Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24942

Summary

Enables small GTPase binding activity. Involved in protein geranylgeranylation. Part of Rab-protein geranylgeranyltransferase complex. Human ortholog(s) of this gene implicated in choroideremia. Orthologous to human CHM (CHM Rab escort protein). [provided by Alliance of Genome Resources, Apr 2022]

Chm Products (1)

mRNA Protein Name
NM_017067.1 NP_058763.1 rab proteins geranylgeranyltransferase component A 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15186776 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
12620235 RGD
enables small GTPase binding IDA
IDA: Inferred from direct assay
8513495 RGD
Biological Process GO Annotation Evidence References Source
involved in protein geranylgeranylation IDA
IDA: Inferred from direct assay
15186776 RGD
Cellular Component GO Annotation Evidence References Source
part of Rab-protein geranylgeranyltransferase complex IDA
IDA: Inferred from direct assay
15186776 RGD
part of Rab-protein geranylgeranyltransferase complex IMP
IMP: Inferred from mutant phenotype
12620235 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

rab proteins geranylgeranyltransferase component A 1

  • CHM, Rab escort protein 1

  • REP-1

  • choroideraemia protein homolog

  • choroideremia (Rab escort protein 1)

  • choroideremia protein homolog

  • choroidermia

  • rab escort protein 1

Chm Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Chm P37727 Rab7a Rattus norvegicus P09527
X-Ray Diffraction
15186776
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-103257 CHM-1 Inhibitor 99.57% Unkown
HY-120482 CHM-1-P-Na Control / Unkown
HY-RS02636 CHM Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08633 MPZ Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-170700 CHM-FUBIATA / Unkown
HY-RS19561 Chm Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26057 Chm Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W754600 BZO-CHMOXIZID Activator / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Chm NCBI NCBI:1121