Tacr2 - tachykinin receptor 2 Gene

Also Known as Tac2r

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25007

About Tacr2

Primary_assembly 20: 30,208,907-30,223,446 forward strand.mRatBN7.2:CM026993.1

This gene has 1 transcript (splice variant), 200 orthologues, 50 paralogues and is associated with 6 phenotypes. Biased expression in Adrenal (RPKM 43.), Uterus (RPKM 5.5) and 1 other tissue.

Summary

Enables substance K receptor activity. Involved in several processes, including operant conditioning; positive regulation of uterine smooth muscle contraction; and regulation of secretion by cell. Located in membrane. Used to study colitis and pulmonary hypertension. Biomarker of colitis. Human ortholog(s) of this gene implicated in asthma. Orthologous to human TACR2 (tachykinin receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Tacr2 Products (1)

mRNA Protein Name
NM_080768.1 NP_542946.1 substance-K receptor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables substance K receptor activity IDA
IDA: Inferred from direct assay
1662278 RGD
Biological Process GO Annotation Evidence References Source
involved in intestine smooth muscle contraction IMP
IMP: Inferred from mutant phenotype
11275010 RGD
involved in negative regulation of luteinizing hormone secretion IMP
IMP: Inferred from mutant phenotype
9376629 RGD
involved in operant conditioning IMP
IMP: Inferred from mutant phenotype
17324063 RGD
involved in positive regulation of acetylcholine secretion, neurotransmission IMP
IMP: Inferred from mutant phenotype
12747940 RGD
involved in positive regulation of monoatomic ion transport IMP
IMP: Inferred from mutant phenotype
11275010 RGD
involved in positive regulation of uterine smooth muscle contraction IDA
IDA: Inferred from direct assay
12390879 RGD
involved in positive regulation of vascular permeability IMP
IMP: Inferred from mutant phenotype
9374705 RGD
involved in prolactin secretion IMP
IMP: Inferred from mutant phenotype
9376629 RGD
involved in response to electrical stimulus IEP
IEP: Inferred from expression pattern
18440496 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Tacr2 Protein Structure

7tmA_SKR_NK2R

7tmA_SKR_NK2R: cd16004 (33 - 317)

7tmA_SKR_NK2R

7tmA_SKR_NK2R: cd16004 (34 - 60)

7tmA_SKR_NK2R

7tmA_SKR_NK2R: cd16004 (67 - 93)

7tmA_SKR_NK2R

7tmA_SKR_NK2R: cd16004 (105 - 135)

7tmA_SKR_NK2R

7tmA_SKR_NK2R: cd16004 (146 - 167)

7tmA_SKR_NK2R

7tmA_SKR_NK2R: cd16004 (193 - 222)

7tmA_SKR_NK2R

7tmA_SKR_NK2R: cd16004 (242 - 272)

7tmA_SKR_NK2R

7tmA_SKR_NK2R: cd16004 (285 - 310)

  • 0
  • 100
  • 200
  • 300
  • 390 a.a.
Protein Preferred Names Protein Names

substance-K receptor

  • NK-2 receptor

  • NK-2R

  • SKR

  • Tachykinin 2 (substance K) receptor

  • neurokinin A receptor

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P3848 Tyr0-Neurokinin A Agonist / Unkown
HY-RS14146 TACR2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14147 Tacr2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14148 Tacr2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tacr2 NCBI NCBI:6865