Slc16a1 - solute carrier family 16 member 1 Gene

Also Known as MCT1; RNMCT1; RATMCT1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25027

About Slc16a1

Primary_assembly 2: 192,124,289-192,144,611 forward strand.mRatBN7.2:CM026975.1

This gene has 2 transcripts (splice variants), 339 orthologues, 13 paralogues and is associated with 8 phenotypes. Biased expression in Heart (RPKM 11.1), Thymus (RPKM 589.2) and 9 other tissues.

Summary

Enables identical protein binding activity; monocarboxylic acid transmembrane transporter activity; and organic cyclic compound binding activity. Involved in cellular response to organic cyclic compound and plasma membrane lactate transport. Located in apical plasma membrane and basolateral plasma membrane. Is integral component of plasma membrane. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 7. Orthologous to human SLC16A1 (solute carrier family 16 member 1). [provided by Alliance of Genome Resources, Apr 2022]

Slc16a1 Products (1)

mRNA Protein Name
NM_012716.2 NP_036848.1 monocarboxylate transporter 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables carboxylic acid transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
10714609 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
19473976 RGD
enables lactate:proton symporter activity IDA
IDA: Inferred from direct assay
9639576 RGD
enables monocarboxylic acid transmembrane transporter activity IDA
IDA: Inferred from direct assay
8526936 RGD
enables organic cyclic compound binding IMP
IMP: Inferred from mutant phenotype
19473976 RGD
enables organic cyclic compound binding IPI
IPI: Inferred from physical interaction
19473976 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
11719518 RGD
enables solute:proton symporter activity IDA
IDA: Inferred from direct assay
9374487 RGD
Biological Process GO Annotation Evidence References Source
involved in carboxylic acid transmembrane transport IMP
IMP: Inferred from mutant phenotype
10714609 RGD
involved in cellular response to organic cyclic compound IEP
IEP: Inferred from expression pattern
19473976 RGD
involved in cellular response to organic cyclic compound IMP
IMP: Inferred from mutant phenotype
19473976 RGD
involved in lactate transmembrane transport IDA
IDA: Inferred from direct assay
19473976 RGD
involved in lactate transmembrane transport IMP
IMP: Inferred from mutant phenotype
19473976 RGD
involved in monocarboxylic acid transport IDA
IDA: Inferred from direct assay
8526936 RGD
involved in plasma membrane lactate transport IDA
IDA: Inferred from direct assay
19929853 RGD
involved in plasma membrane lactate transport IMP
IMP: Inferred from mutant phenotype
17127621 RGD
involved in pyruvate transmembrane transport IDA
IDA: Inferred from direct assay
9639576 RGD
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
18619525 RGD
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
10564700 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
11719518 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Slc16a1 Protein Structure

2A0113

2A0113: TIGR00892 (0 - 461)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 494 a.a.
Protein Preferred Names Protein Names

monocarboxylate transporter 1

  • MCT 1

  • solute carrier 16 (monocarboxylic acid transporter), member 1

  • solute carrier family 16 (monocarboxylate transporter), member 1

  • solute carrier family 16 (monocarboxylic acid transporters), member 1

  • solute carrier family 16, member 1 (monocarboxylic acid transporter 1)

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13016 SLC16A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-182416 slCeMM1 Inhibitor / Unkown
HY-RS13017 Slc16a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13018 Slc16a1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc16a1 NCBI NCBI:6566