Apoa1 - apolipoprotein A1 Gene

Also Known as apoA-I

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25081

Summary

Enables amyloid-beta binding activity; Cholesterol transfer activity; and Lipase Inhibitor activity. Involved in several processes, including lipid transport; peripheral nervous system axon regeneration; and response to estrogen. Located in cell surface; extracellular space; and nucleus. Part of discoidal high-density lipoprotein particle; intermediate-density lipoprotein particle; and low-density lipoprotein particle. Used to study arteriosclerosis and hyperthyroidism. Biomarker of several diseases, including fatty liver disease (multiple); hypertension; major depressive disorder; ocular hypertension; and sciatic neuropathy. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); familial visceral amyloidosis; hypolipoproteinemia (multiple); non-alcoholic steatohepatitis; and systemic lupus erythematosus. Orthologous to human APOA1 (Apolipoprotein A1). [provided by Alliance of Genome Resources, Apr 2022]

Apoa1 Products (1)

mRNA Protein Name
NM_012738.2 NP_036870.1 apolipoprotein A-I preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables amyloid-beta binding IPI
IPI: Inferred from physical interaction
9211985 RGD
enables cholesterol transfer activity IDA
IDA: Inferred from direct assay
1537840 RGD
enables lipase inhibitor activity IDA
IDA: Inferred from direct assay
10419291 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
18391222 RGD
Biological Process GO Annotation Evidence References Source
involved in animal organ regeneration IDA
IDA: Inferred from direct assay
2123716 RGD
involved in cholesterol transport IDA
IDA: Inferred from direct assay
1537840 RGD
involved in negative regulation of lipase activity IDA
IDA: Inferred from direct assay
10419291 RGD
involved in peripheral nervous system axon regeneration IEP
IEP: Inferred from expression pattern
2120218 RGD
involved in phospholipid transport IDA
IDA: Inferred from direct assay
11773045 RGD
involved in response to estrogen IEP
IEP: Inferred from expression pattern
2504861 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
2504861 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
7556148 RGD
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
2493483 RGD
part of discoidal high-density lipoprotein particle IDA
IDA: Inferred from direct assay
2493483 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
2579677 RGD
part of high-density lipoprotein particle IDA
IDA: Inferred from direct assay
9211985 RGD
part of intermediate-density lipoprotein particle IDA
IDA: Inferred from direct assay
9211985 RGD
part of low-density lipoprotein particle IDA
IDA: Inferred from direct assay
9211985 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

apolipoprotein A-I

  • apo-AI

  • apolipoprotein A-1

  • preproapolipoprotein A-I

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-13031 GW 841819X Activator / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Apoa1 NCBI NCBI:335
Mus musculus Apoa1 NCBI NCBI:11806