Foxa1 - forkhead box A1 Gene

Also Known as Hnf3a

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25098

Summary

Enables several functions, including DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleus. Orthologous to human FOXA1 (forkhead box A1). [provided by Alliance of Genome Resources, Apr 2022]

Foxa1 Products (1)

mRNA Protein Name
NM_012742.2 NP_036874.2 hepatocyte nuclear factor 3-alpha

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
10024498 RGD
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
17220277 RGD
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
17220277 RGD
enables double-stranded DNA binding IDA
IDA: Inferred from direct assay
10024498 RGD
enables protein domain specific binding IDA
IDA: Inferred from direct assay
18003659 RGD
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
2227418 RGD
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
17220277 RGD
involved in positive regulation of hydrogen peroxide-mediated programmed cell death IMP
IMP: Inferred from mutant phenotype
19649697 RGD
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
10024498 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

hepatocyte nuclear factor 3-alpha

  • HNF-3-alpha

  • HNF-3A

  • forkhead box protein A1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-168534 WX-02-23 99.88% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Foxa1 NCBI NCBI:3169