2. Gene
  3. Stat5b - signal transducer and activator of transcription 5B Gene

Stat5b - signal transducer and activator of transcription 5B Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 25126 | Gene type: protein coding

About Stat5b

Primary_assembly 10: 85,705,670-85,775,668 reverse strand.mRatBN7.2:CM026983.1

This gene has 4 transcripts (splice variants), 286 orthologues, 5 paralogues and is associated with 17 phenotypes. Biased expression in Muscle (RPKM 432.5), Thymus (RPKM 364.1) and 9 other tissues.

Summary

Enables DNA binding activity; DNA-binding transcription factor activity; and chromatin binding activity. Involved in several processes, including cellular response to epidermal growth factor stimulus; luteinization; and receptor signaling pathway via JAK-STAT. Located in cytosol and nucleus. Human ortholog(s) of this gene implicated in growth hormone insensitivity syndrome with immune dysregulation 1 and growth hormone insensitivity syndrome with immune dysregulation 2. Orthologous to human STAT5B (signal transducer and activator of transcription 5B). [provided by Alliance of Genome Resources, Apr 2022]

Stat5b Products(1)

mRNA Protein Name
NM_022380.2 NP_071775.1 signal transducer and activator of transcription 5B

Stat5b Protein Structure

STAT_int

STAT_int: pfam02865 (64 - 132)

STAT5_CCD

STAT5_CCD: cd16855 (147 - 338)

STAT5_DBD

STAT5_DBD: cd16849 (340 - 497)

SH2_STAT5b

SH2_STAT5b: cd10420 (581 - 725)

  • 0
  • 200
  • 400
  • 600
  • 795 a.a.
Protein Preferred Names Protein Names

signal transducer and activator of transcription 5B

Signal transducer and activator of transcription 5a

Related Agents

Pre-clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-112647 Stafib-1 Inhibitor ≥98.0% Unkown
HY-136546 Stafia-1 Inhibitor 99.37% Unkown
HY-148813 AK-2292 99.73% Unkown
HY-19527 IST5-002 99.36% Unkown
HY-112648 Stafib-2 Inhibitor 98.42% Unkown
HY-112649 Pomstafib-2 / Unkown
HY-RS13893 STAT5B Human Pre-designed siRNA Set A / Unkown
HY-RS13894 Stat5b Mouse Pre-designed siRNA Set A / Unkown
HY-RS13895 Stat5b Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Stat5b NCBI NCBI:6777