Bmp4 - bone morphogenetic protein 4 Gene

Also Known as BOMPR4A

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25296

Summary

Enables growth factor activity and identical protein binding activity. Involved in several processes, including animal organ development; positive regulation of calcium ion transport; and positive regulation of cell differentiation. Acts upstream of or within positive regulation of ossification and positive regulation of transcription by RNA polymerase II. Located in cytoplasm; extracellular space; and vesicle. Biomarker of Barrett's esophagus; congenital diaphragmatic hernia; epilepsy; peptic esophagitis; and prolactinoma. Human ortholog(s) of this gene implicated in several diseases, including CAKUT (multiple); cleft lip; orofacial cleft 11; ossification of the posterior longitudinal ligament of spine; and otosclerosis. Orthologous to human BMP4 (bone morphogenetic protein 4). [provided by Alliance of Genome Resources, Apr 2022]

Bmp4 Products (1)

mRNA Protein Name
NM_012827.2 NP_036959.2 bone morphogenetic protein 4 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables growth factor activity IDA
IDA: Inferred from direct assay
12475223 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
16245174 RGD
Biological Process GO Annotation Evidence References Source
involved in anatomical structure regression IEP
IEP: Inferred from expression pattern
12808102 RGD
involved in cardiac muscle hypertrophy in response to stress IMP
IMP: Inferred from mutant phenotype
26873969 RGD
involved in cellular response to BMP stimulus IEP
IEP: Inferred from expression pattern
9246083 RGD
involved in cellular response to dexamethasone stimulus IDA
IDA: Inferred from direct assay
17537984 RGD
involved in cellular response to mechanical stimulus IEP
IEP: Inferred from expression pattern
20877159 RGD
involved in cellular response to oxidative stress IDA
IDA: Inferred from direct assay
22710965 RGD
involved in cellular response to thyroid hormone stimulus IEP
IEP: Inferred from expression pattern
12395077 RGD
involved in epithelial tube branching involved in lung morphogenesis IEP
IEP: Inferred from expression pattern
8769111 RGD
involved in lung lobe development IEP
IEP: Inferred from expression pattern
15991191 RGD
involved in negative regulation of oligodendrocyte differentiation IMP
IMP: Inferred from mutant phenotype
16388796 RGD
involved in ovarian follicle development IMP
IMP: Inferred from mutant phenotype
12801979 RGD
involved in positive regulation of bone mineralization IDA
IDA: Inferred from direct assay
15352071 RGD
involved in positive regulation of branching involved in ureteric bud morphogenesis IMP
IMP: Inferred from mutant phenotype
17537984 RGD
involved in positive regulation of calcium ion transport into cytosol IMP
IMP: Inferred from mutant phenotype
20844246 RGD
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
17286956 RGD
involved in positive regulation of endothelial cell apoptotic process IMP
IMP: Inferred from mutant phenotype
12808102 RGD
involved in positive regulation of hepatocyte differentiation IMP
IMP: Inferred from mutant phenotype
19229878 RGD
involved in positive regulation of mesenchymal stem cell proliferation IMP
IMP: Inferred from mutant phenotype
19723531 RGD
involved in positive regulation of neuron differentiation IMP
IMP: Inferred from mutant phenotype
19287192 RGD
involved in positive regulation of neuron projection development IDA
IDA: Inferred from direct assay
23325243 RGD
involved in positive regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
23325243 RGD
acts upstream of or within positive regulation of ossification IDA
IDA: Inferred from direct assay
7911662 RGD
involved in positive regulation of ossification IMP
IMP: Inferred from mutant phenotype
17112416 RGD
involved in positive regulation of osteoblast differentiation IDA
IDA: Inferred from direct assay
16245174 RGD
involved in positive regulation of osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
17112416 RGD
involved in positive regulation of store-operated calcium channel activity IMP
IMP: Inferred from mutant phenotype
20844246 RGD
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
7911662 RGD
involved in regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
19229878 RGD
involved in regulation of cell differentiation IDA
IDA: Inferred from direct assay
12514223 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
16551644 RGD
involved in response to glucocorticoid IEP
IEP: Inferred from expression pattern
17537984 RGD
involved in response to mechanical stimulus IEP
IEP: Inferred from expression pattern
10404008 RGD
involved in response to nitric oxide IEP
IEP: Inferred from expression pattern
15991191 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
12730624 RGD
involved in response to retinoic acid IEP
IEP: Inferred from expression pattern
8385738 RGD
involved in response to testosterone IEP
IEP: Inferred from expression pattern
20660069 RGD
involved in retina development in camera-type eye IEP
IEP: Inferred from expression pattern
17069773 RGD
involved in tongue morphogenesis IEP
IEP: Inferred from expression pattern
16828469 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
18758911 RGD
located in vesicle IDA
IDA: Inferred from direct assay
18758911 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

bone morphogenetic protein 4

  • BMP-2B

  • BMP-4

  • bone morphogenetic protein 2B

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (13)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-124697 BMP signaling agonist sb4 Agonist 99.98% Unkown
HY-16712 LDN-214117 Inhibitor 99.54% Unkown
HY-18961 PD 407824 Inhibitor 99.00% Unkown
HY-147372 SJ000063181 Activator 98.92% Unkown
HY-N0836 Jervine 99.28% Unkown
HY-P10710A BMP-4 (15-24) acetate Inhibitor 99.30% Unkown
HY-N9409 2-Hydroxymelatonin / Unkown
HY-P10710 BMP-4 (15-24) Inhibitor / Unkown
HY-RS01539 BMP4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-179400 LDN-193688 Inhibitor / Unkown
HY-N0836A Jervine hydriodide / Unkown
HY-RS16511 Bmp4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22943 Bmp4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991879 Anti-BMP-4 Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bmp4 NCBI NCBI:652