Lipe - lipase E, hormone sensitive type Gene

Also Known as HSL; REH

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25330

Summary

Enables carboxylic ester hydrolase activity. Involved in female pregnancy; response to xenobiotic stimulus; and triglyceride catabolic process. Located in cytoplasm and extracellular space. Used to study arteriosclerosis and heart disease. Biomarker of obesity. Human ortholog(s) of this gene implicated in familial partial lipodystrophy type 6 and hypertension. Orthologous to human LIPE (Lipase E, hormone sensitive type). [provided by Alliance of Genome Resources, Apr 2022]

Lipe Products (1)

mRNA Protein Name
NM_012859.1 NP_036991.1 hormone-sensitive lipase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables diacylglycerol lipase activity IDA
IDA: Inferred from direct assay
6643478 RGD
enables hydrolase activity, acting on ester bonds IDA
IDA: Inferred from direct assay
15697220 RGD
enables monoacylglycerol lipase activity IDA
IDA: Inferred from direct assay
15627655 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
10318917 RGD
enables retinyl-palmitate esterase activity IDA
IDA: Inferred from direct assay
9162045 RGD
enables sterol ester esterase activity IDA
IDA: Inferred from direct assay
9162045 RGD
enables triacylglycerol lipase activity IDA
IDA: Inferred from direct assay
9162045 RGD
Biological Process GO Annotation Evidence References Source
involved in female pregnancy IEP
IEP: Inferred from expression pattern
16328496 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
11016888 RGD
involved in triglyceride catabolic process IDA
IDA: Inferred from direct assay
14739077 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
15654127 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

hormone-sensitive lipase

  • lipase, hormone sensitive

  • monoacylglycerol lipase LIPE

  • retinyl ester hydrolase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-112083 BAY-3827 Inhibitor 99.72% Unkown
HY-153523 Hi 76-0079 Inhibitor 99.87% Unkown
HY-RS07687 LIPE Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18621 Lipe Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25107 Lipe Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lipe NCBI NCBI:3991