2. Gene
  3. Mgmt - O-6-methylguanine-DNA methyltransferase Gene

Mgmt - O-6-methylguanine-DNA methyltransferase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 25332 | Gene type: protein coding

About Mgmt

Primary_assembly 1: 191,710,930-191,937,756 forward strand.mRatBN7.2:CM026974.1

This gene has 3 transcripts (splice variants), 189 orthologues and is associated with 31 phenotypes. Biased expression in Liver (RPKM 16.5), Spleen (RPKM 119.4) and 9 other tissues.

Summary

Enables calcium ion binding activity and methylated-DNA-[protein]-cysteine S-methyltransferase activity. Involved in several processes, including DNA dealkylation involved in DNA repair; cellular response to ionizing radiation; and response to folic acid. Located in nucleus. Biomarker of colon adenocarcinoma and melanoma. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endocrine gland Cancer (multiple); granulosa cell tumor; nervous system Cancer (multiple); and urinary bladder Cancer. Orthologous to human MGMT (O-6-methylguanine-DNA methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Mgmt Products(1)

mRNA Protein Name
NM_012861.1 NP_036993.1 methylated-DNA--protein-cysteine methyltransferase

Mgmt Protein Structure

AdaB

AdaB: COG0350 (5 - 177)

  • 0
  • 100
  • 209 a.a.
Protein Preferred Names Protein Names

methylated-DNA--protein-cysteine methyltransferase

0-6-methylguanine-DNA methyltransferase

6-O-methylguanine-DNA methyltransferase

O(6)-alkylguanine-DNA alkyltransferase

O-6-methylguanine-DNA-alkyltransferase

O6-alkylguanine-DNA alkyltransferase

O6-methylguanine-DNA methyltranferase

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13668 Lomeguatrib Inhibitor 99.70% Unkown
HY-13057 O6BTG-octylglucoside Inhibitor ≥95.0% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mgmt NCBI NCBI:4255