Mgmt - O-6-methylguanine-DNA methyltransferase Gene

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 25332

About Mgmt

Primary_assembly 1: 191,710,930-191,937,756 forward strand.mRatBN7.2:CM026974.1

This gene has 3 transcripts (splice variants), 189 orthologues and is associated with 31 phenotypes. Biased expression in Liver (RPKM 16.5), Spleen (RPKM 119.4) and 9 other tissues.

Summary

Enables calcium ion binding activity and methylated-DNA-[protein]-cysteine S-methyltransferase activity. Involved in several processes, including DNA dealkylation involved in DNA repair; cellular response to ionizing radiation; and response to folic acid. Located in nucleus. Biomarker of colon adenocarcinoma and melanoma. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endocrine gland Cancer (multiple); granulosa cell tumor; nervous system Cancer (multiple); and urinary bladder Cancer. Orthologous to human MGMT (O-6-methylguanine-DNA methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Mgmt Products (2)

mRNA	Protein	Name
NM_012861.1	NP_036993.1	methylated-DNA--protein-cysteine methyltransferase
NM_012861.1	NP_036993.1	methylated-DNA--protein-cysteine methyltransferase

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables calcium ion binding	IDA IDA: Inferred from direct assay	12479403	RGD
enables methylated-DNA-[protein]-cysteine S-methyltransferase activity	IDA IDA: Inferred from direct assay	15025514	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in DNA alkylation repair	IDA IDA: Inferred from direct assay	15025514	RGD
involved in DNA damage response	IEP IEP: Inferred from expression pattern	12815001	RGD
involved in cellular response to ionizing radiation	IEP IEP: Inferred from expression pattern	9780001	RGD
involved in cellular response to organic cyclic compound	IEP IEP: Inferred from expression pattern	19549930	RGD
involved in cellular response to oxidative stress	IEP IEP: Inferred from expression pattern	11133343	RGD
involved in mammary gland epithelial cell differentiation	IEP IEP: Inferred from expression pattern	16086375	RGD
involved in positive regulation of DNA repair	IDA IDA: Inferred from direct assay	1945835	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	11524300	RGD
involved in response to folic acid	IEP IEP: Inferred from expression pattern	20051376	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	12517412	RGD
involved in response to toxic substance	IEP IEP: Inferred from expression pattern	20011461	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	19860839	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mgmt Protein Structure

AdaB

0
100
209 a.a.

Protein Preferred Names	Protein Names
methylated-DNA--protein-cysteine methyltransferase	0-6-methylguanine-DNA methyltransferase 6-O-methylguanine-DNA methyltransferase O(6)-alkylguanine-DNA alkyltransferase O-6-methylguanine-DNA-alkyltransferase O6-alkylguanine-DNA alkyltransferase O6-methylguanine-DNA methyltranferase

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-13668	Lomeguatrib	Inhibitor	99.77%	Phase 2

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13057	O6BTG-octylglucoside	Inhibitor	95.0%	Unkown
HY-175299	Hedgehog IN-11	Inhibitor	/	Unkown
HY-186228	Anticancer agent 333		/	Unkown
HY-180540	MGMT-IN-1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mgmt	NCBI	NCBI:4255