MGMT - O-6-methylguanine-DNA methyltransferase Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4255

About MGMT

Cytogenetic location: 10q26.3 Genomic coordinates (GRCh38): 10:129,467,241-129,770,983 (from NCBI)

This gene has 5 transcripts (splice variants), 189 orthologues and is associated with 75 phenotypes. Ubiquitous expression in liver (RPKM 6.2), kidney (RPKM 3.0) and 25 other tissues.

Summary

Alkylating agents are potent carcinogens that can result in cell death, mutation and Cancer. The protein encoded by this gene is a DNA repair protein that is involved in cellular defense against mutagenesis and toxicity from alkylating agents. The protein catalyzes transfer of methyl groups from O(6)-alkylguanine and Other methylated moieties of the DNA to its own molecule, which repairs the toxic lesions. Methylation of the genes promoter has been associated with several Cancer types, including colorectal Cancer, lung Cancer, lymphoma and glioblastoma. [provided by RefSeq, Sep 2015]

MGMT Products (2)

mRNA	Protein	Name
NM_002412.5	NP_002403.3	methylated-DNA--protein-cysteine methyltransferase
NM_002412.5	NP_002403.3	methylated-DNA--protein-cysteine methyltransferase

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	24147153	GOA
involved in positive regulation of double-strand break repair	IDA IDA: Inferred from direct assay	24147153	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MGMT Protein Structure

Methyltransf_1N

DNA_binding_1

0
100
200
238 a.a.

Protein Preferred Names	Protein Names
methylated-DNA--protein-cysteine methyltransferase	6-O-methylguanine-DNA methyltransferase O-6-methylguanine-DNA-alkyltransferase O6-methylguanine-DNA methyltransferase methylguanine-DNA methyltransferase

Recombinant MGMT Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70306	MGMT Protein, Human (His)	P16455 (M1-N207)	≥ 95%, as determined by reducing SDS-PAGE.

MGMT Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80224	MGMT Antibody (YA293)	WB, IHC-P	Human
HY-P84131	MGMT Antibody (YA3828)	WB, IHC-P, ICC/IF, FC, ELISA	Human
HY-P84131A	MGMT Antibody (YA3828)(PBS only)	WB, IHC-P, ICC/IF, FC, ELISA	Human
HY-P85856	MGMT Antibody (YA5548)	WB, ICC/IF, ELISA	Human

Related Diseases

Diseases	Alias
Cerebral Lymphoma	Primary Cerebral Lymphoma Brain Primary Lymphoma Primary Lymphoma Of Cerebrum
High Grade Ependymoma	Ependymal Neoplasm Ependymal Tumors Malignant Ependymoma Ependymal Tumor Anaplastic Ependymoma Experimental Organism Malignant Ependymoma Ependymoma Of Brain
Idh-Mutant Anaplastic Astrocytoma
Acidophil Adenoma	Adenoma, Acidophil Eosinophil Adenoma
Spinal Disease	Spinal Disorder Spinal Diseases
Cell Type Benign Neoplasm
Lung Benign Neoplasm	Lung Neoplasms Tumor Of The Lung Lung Tumor
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Prolactin Producing Pituitary Tumor	Prolactin-Producing Pituitary Gland Carcinoma Prolactin-Producing Pituitary Tumor Malignant Prolactin Producing Neoplasm Of Pituitary Gland Malignant Prolactinoma Prolactin Producing Pituitary Tumour Prolactin Secreting Tumor Of Pituitary Prolactin Secreting Tumour Of Pituitary
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Pituitary Carcinoma	Pituitary Cancer Carcinoma Of The Pituitary Gland Malignant Neoplasm Of Pituitary Gland
Idh-Mutant Glioblastoma
Gemistocytic Astrocytoma	Gemistocytic Astrocytic Tumor
Central Nervous System Rhabdomyosarcoma	Rhabdomyosarcoma Of The Cns
Pilocytic Astrocytoma	Juvenile Pilocytic Astrocytoma Grade I Astrocytic Tumor Piloid Astrocytoma
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Anaplastic Pleomorphic Xanthoastrocytoma
Idh-Wildtype Anaplastic Astrocytoma
Spinal Cord Glioma	Glial Tumor Of Spinal Cord Glial Neoplasm Spinal Cord Glioma Of Spinal Cord
Gastric Cancer	Stomach Cancer Stomach Carcinoma Gastric Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Squamous Cell Carcinoma, Head And Neck	Squamous Cell Carcinoma Of The Head And Neck HNSCC Head And Neck Squamous Cell Carcinoma Head And Neck Cancer Squamous Cell Carcinoma Of Lip Squamous Cell Carcinoma, Head And Neck, Somatic Carcinoma Of The Head And Neck Squamous Cell Carcinomas Of Head And Neck Scchn Squamous Cell Carcinoma Of The Hypopharynx Squamous Cell Carcinoma Of The Oropharynx Squamous Cell Carcinoma Of Salivary Glands Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses Squamous Cell Carcinoma Of The Oral Cavity Squamous Cell Carcinoma Of The Lip Carcinoma, Squamous Cell Of Head And Neck Lip Squamous Cell Carcinoma Cancer, Head/Neck Carcinoma, Squamous Cell, Head And Neck Salivary Gland Squamous Cell Carcinoma Cancer Of Head And Neck Squamous Cell Carcinoma Of Oropharynx Nos
Mixed Oligodendroglioma-Astrocytoma	Who Grade Ii Mixed Glioma
Low Grade Glioma	Benign Glioma
Glioblastoma Classical Subtype
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Desmoplastic/Nodular Medulloblastoma Medulloblastoma With Extensive Nodularity Desmoplastic Medulloblastoma Medulloblastoma, Somatic Medulloblastoma, Desmoplastic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Mben Medulloblastoma Desmoplastic Neuroectodermal Tumors, Primitive Medulloblastomas Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Primary Central Nervous System Lymphoma	Pcnsl Primary Cns Lymphoma Primary Brain Lymphoma Primary Lymphoma, Cns Primary Cerebral Lymphoma
Giant Cell Glioblastoma	Monstrocellular Sarcoma
Supratentorial Cancer	Supratentorial Neoplasms Brain Neoplasm, Supratentorial Malignant Supratentorial Tumor Cancer, Supratentorial
Adult Spinal Cord Glioblastoma Multiforme	Glioblastoma Multiforme Of Spinal Cord Adult Spinal Cord Glioblastoma
Diffuse Midline Glioma, H3 K27m-Mutant	Diffuse Intrinsic Pontine Glioma Dipg Infiltrative Brainstem Glioma
Central Nervous System Cancer	Central Nervous System Tumor Central Nervous System Tumors Cns Neoplasm Malignant Neoplasm Of Central Nervous System Malignant Tumor Of Cns Neoplasm Of Central Nervous System Malignant Neoplasm Of The Central Nervous System Neoplasm Of The Central Nervous System Central Nervous System Neoplasms Central Nervous System Neoplasm
Temporal Lobe Neoplasm	Neoplasm Of Temporal Lobe Malignant Neoplasm Of Temporal Lobe Tumor Of Temporal Lobe
Polyposis Syndrome, Hereditary Mixed, 1	HMPS1 Colorectal Adenoma And Carcinoma 1 Crac1 Colorectal Cancer 4 Chromosome 15q13-Q14 Duplication Syndrome, 40-Kb Colorectal Cancer, Susceptibility To, 4 Hereditary Mixed Polyposis Syndrome 1 Polyposis Syndrome, Hereditary Mixed 1 CRCS4 Susceptibility To Colorectal Cancer On Chromosome 15 Polyposis Syndrome, Mixed Hereditary 1 Adenomatous Polyps
Brain Cancer	Malignant Neoplasm Of Brain Adult Brain Tumor Brain Neoplasms Brain Neoplasm Neoplasm Of Brain Primary Malignant Neoplasm Of Brain Brain Tumors Adult Malignant Brain Neoplasm Brain Neoplasm, Adult Bt - Brain Tumour Malignant Brain Tumour Malignant Primary Brain Neoplasm Malignant Primary Brain Tumor Malignant Tumor Of Adult Brain Malignant Tumor Of Brain Primary Brain Neoplasm Primary Brain Tumor Tumor Of The Brain Brain Tumor, Adult Brain Tumor Primary Malignant Primary Brain Tumors Primary Brain Tumors Cancer, Brain Brain Tumor, Primary
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Cancer Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Familial Adenomatous Polyposis	Adenomatous Polyposis Coli Fap Familial Multiple Polyposis Syndrome Adenomatous Polyposis Of The Colon Familial Intestinal Polyposis Familial Polyposis Coli Fpc Familial Adenomatous Polyposis Of The Colon Familial Multiple Polyposis Familial Polyposis Of The Colon Hereditary Polyposis Coli Polyposis, Adenomatous Intestinal Adenomatous Familial Polyposis Adenomatous Familial Polyposis Syndrome Myh-Associated Polyposis Colorectal Adenomatous Polyposis Adenomatous Polyposis, Familial Mutyh-Associate Polyposis
Frontal Lobe Neoplasm	Neoplasm Of Frontal Lobe Malignant Neoplasm Of Frontal Lobe Tumor Of Frontal Lobe
Oligoastrocytoma	Mixed Oligoastrocytoma Moa Oligoastrocytoma Mixed Mixed Oligodendroglioma-Astrocytoma
Pituitary Adenoma	Pituitary Neoplasms Adenoma Of The Pituitary Gland Pituitary Adenomas Adenoma, Pituitary Pituitary Gland Adenoma
Xeroderma Pigmentosum, Variant Type	Xeroderma Pigmentosum XPV Xeroderma Pigmentosum Variant Type Xeroderma Pigmentosum With Normal Dna Repair Rates Photosensitivity With Defective Dna Synthesis De Sanctis-Cacchione Syndrome Xp Desanctis-Cacchione Syndrome Xeroderma Pigmentosa Xerodermic Idiocy Xeroderma Pigmentosum Variant Xp - [Xeroderma Pigmentosum] Atrophoderma Pigmentosum
Pleomorphic Xanthoastrocytoma	Pxa Pleomorphic Xantho-Astrocytoma
Spinal Cord Oligodendroglioma	Oligodendroglioma Of Spinal Cord Well Differentiated Spinal Cord Oligodendroglioma
Anaplastic Astrocytoma	Grade Iii Astrocytoma Grade Iii Astrocytic Tumor Astrocytoma, Anaplastic
Oligodendroglioma	Oligodendroglial Neoplasm Oligodendroglial Tumor Oligodendroglial Tumors Well Differentiated Oligodendroglioma
Pancytopenia
Spinal Cord Lipoma	Lipoma Of Spinal Cord
Central Nervous System Benign Neoplasm	Benign Neoplasm Of The Central Nervous System
Gliosarcoma	Glioblastoma With Sarcomatous Component Sarcomatous Glioblastoma
Gliomatosis Cerebri	Astrocytosis Cerebri Neoplasms, Neuroepithelial
Brain Glioblastoma Multiforme	Brain Glioblastoma Glioblastoma Multiforme Of Brain Glioblastoma Nos
Idh-Wildtype Glioblastoma
Lymphoma	Lymphoid Cancer Lymphomas Lymphoid Cancers Lymphoid Neoplasm Lymphoma Nos Nhl - [Non-Hodgkin Lymphoma] Non-Hodgkin Lymphoma Non-Hodgkin Lymphoma, Nos Non-Hodgkin Malignant Lymphoma Nos
Glioma
Spinal Cord Disease	Spinal Cord Diseases Myelopathy Bone Marrow Diseases
Adult Brain Stem Glioma	Adult Brainstem Neuroglial Tumor
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Protection Against Lung Cancer, Susceptibility To Adenocarcinoma Of Lung, Somatic Nonsmall Cell Lung Cancer Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Rhabdomyosarcoma
Alpha-Thalassemia	Alpha Thalassemia Alpha Thalassaemia Alpha Plus Thalassemia Thalassemia, Alpha- Thalassemias, Alpha- A-Thalassemia Α-Thalassemia A-THAL Thalassemia Alpha Thalassaemia Syndrome
Brain Glioma	Lower Grade Glioma Intracranial Glioma Glioma Nos
Anaplastic Oligodendroglioma
Infratentorial Cancer	Infratentorial Neoplasms Brain Neoplasm, Infratentorial Malignant Infratentorial Tumors
Neuroma
Cerebrum Cancer	Cerebral Cancer Neoplasm Of Cerebrum Tumor Of Cerebrum Malignant Neoplasm Of Cerebrum
Cerebral Ventricle Cancer	Cerebral Ventricle Neoplasms Cerebral Ventricle Neoplasm Intraventricular Tumor Of Brain
Protoplasmic Astrocytoma	Protoplasmic Astrocytic Tumor Astrocytoma Protoplasmic
Diffuse Glioma, H3 G34 Mutant
High Grade Glioma	Malignant Glioma Glial Cell Tumor Glioma, Malignant Malignant Neuroglial Tumor Neuroglial Tumor Glioma Malignant Gliomas
Mixed Glioma	Mixed Gliomas Mixed Neuroglial Tumor Glioma
Testicular Cancer	Testis Cancer Testicular Carcinoma Testicular Neoplasms Malignant Neoplasm Of Testis Childhood Neoplasm Of The Testis Neoplasm Of Testis Pediatric Testicular Neoplasm Testicular Tumor Testis Neoplasm Testicular Tumors Testicular Neoplasm Testicular Malignant Germ Cell Tumor Childhood Testicular Neoplasm Carcinoma Of The Testis Cancer Of Testis Malignant Neoplasm Of Testis, Nos Malignant Neoplasm Of Testis, Unspecified Malignant Tumour Of Testis Testicle Cancer Primary Malignant Neoplasm Of Testis
Mismatch Repair Cancer Syndrome	Turcot Syndrome Brain Tumor-Polyposis Syndrome 1 Btp1 Syndrome Btps1 Childhood Cancer Syndrome Cmmr-D Syndrome Cmmrds Constitutional Mismatch Repair Deficiency Syndrome Mmr Deficiency Cancer Syndrome, Mismatch Repair Malignant Childhood Neoplasm
Colonic Benign Neoplasm	Colon Neoplasm Colonic Mass Colonic Tumor Neoplasm Of Colon Neoplasm Of The Colon Colonic Neoplasms Colon Cancer Colon Carcinoma Nos Colonic Cancer Metastatic Colon Cancer Nos
Lung Cancer Susceptibility 3	Lung Adenocarcinoma Adenocarcinoma Of Lung LNCR3 Adenocarcinoma Of Lung, Susceptibility To Bronchogenic Lung Adenocarcinoma Nonsmall Cell Adenocarcinoma Adenocarcinoma Lung Lung Adenocarcinomas Non-Small Cell Adenocarcinoma
Nelson Syndrome	Nelson'S Syndrome Dermal Ridges Ridges-Off-The-End Syndrome Postadrenalectomy Cushing Syndrome
Adenoma	Acinar Cell Adenoma Adenomas Acinic Cell Adenoma
Histoplasmosis Meningitis	Histoplasmosis With Meningitis Histoplasmosis, Unspecified, Meningitis
Gallbladder Cancer	Gallbladder Carcinoma Gallbladder Neoplasm Malignant Neoplasm Of Gallbladder Malignant Tumour Of Gallbladder Gallbladder Ca Localized Malignant Gallbladder Neoplasm Malignant Tumor Of The Gallbladder Tumor Of The Gallbladder Cancer Of The Gallbladder Carcinoma Gallbladder Carcinoma Of Gallbladder Gallbladder Neoplasms Malignant Neoplasm Of Gallbladder Localized Cancer Of Gallbladder Primary Malignant Neoplasm Of Gallbladder
Histone Mutated Tumor	Histone Mutated Tumour
Childhood Oligodendroglioma	Pediatric Oligodendroglioma Oligodendroglioma, Childhood
Neural Tube Defects	Spina Bifida Neural Tube Defect NTD Neural Tube Defects, Susceptibility To Spinal Dysraphism Spina Bifida, Susceptibility To Rachischisis Cleft Spine Open Spine Hydrocele Spinalis Neural Tube Defect Nos Sb - [Spina Bifida] Spinal Hernia Nos Spinal Fissure Nos
Connective Tissue Cancer	Neoplasms, Connective Tissue Connective Tissue Neoplasm Mesenchymal Tissue Malignant Neoplasm Neoplasm Of Connective Tissues Tumour Of Connective Tissue
Meningioma, Familial	Meningioma Familial Meningioma Meningioma, Familial, Susceptibility To Meningeal Neoplasm Meningeal Neoplasms Meningiomas Meningioma, Nf2-Related, Somatic Meningioma, Sis-Related Meningothelial Cell Tumor Neoplasm Of The Meninges Primary Meningeal Tumor Familial Multiple Meningioma MNGMA Meningioma, Benign, No Icd-O Subtype Intracranial Meningioma Meningothelial Cell Neoplasm Supratentorial Meningioma Primary Neoplasm Of Spinal Meninges Benign Intracranial Meningioma Benign Meningioma Meningeal Tumours Meningeal Sarcoma Of Unspecified Site Meningothelial Sarcoma Of Unspecified Site
Childhood Medulloblastoma	Medulloblastoma, Childhood Pediatric Medulloblastoma Medulloblastoma Childhood
Melanoma, Cutaneous Malignant 1	Familial Melanoma Melanoma, Cutaneous Malignant, Susceptibility To, 1 CMM1 Melanoma, Cutaneous Malignant Cmm Melanoma, Malignant Familial Atypical Mole-Malignant Melanoma Syndrome Fammm Melanoma, Familial Mlm Dysplastic Nevus Syndrome, Hereditary Dns B-K Mole Syndrome Melanoma, Cutaneous Malignant, 1 Malignant Melanoma, Cutaneous Melanoma, Cutaneous, Malignant, Susceptibility To, Type 1 Dysplastic Nevus Syndrome Cutaneous Melanoma Familial Atypical Mole Melanoma Syndrome Hereditary Melanoma
Lynch Syndrome	Hereditary Nonpolyposis Colon Cancer Hereditary Nonpolyposis Colorectal Cancer Hereditary Nonpolyposis Colorectal Carcinoma Hereditary Nonpolyposis Colorectal Neoplasms Familial Nonpolyposis Colon Cancer Hnpcc Coca 1 Hereditary Defective Mismatch Repair Syndrome Hereditary Non-Polyposis Colon Cancer Hereditary Non-Polyposis Colon Cancer Syndrome Hereditary Non-Polyposis Colorectal Cancer Hereditary Non-Polyposis Colorectal Cancer Syndrome Hereditary Nonpolyposis Colon Cancer Syndrome Hereditary Nonpolyposis Colorectal Cancer Syndrome Hereditary Nonpolyposis Colorectal Neoplasm Hnpcc - Hereditary Nonpolyposis Colon Cancer Cancer Family Syndrome Familial Nonpolyposis Colorectal Cancer Colon Cancer, Familial Nonpolyposis Colorectal Neoplasms, Hereditary Nonpolyposis Cancer, Colorectal, Nonpolyposis, Hereditary Colorectal Cancer, Hereditary Nonpolyposis, Type 1
Malignant Astrocytoma	Astrocytic Tumor Astrocytoma Of Brain Astrocytoma Of Cerebrum Astroglioma Cerebral Astrocytoma Astrocytoma
Diffuse Astrocytoma	Diffuse Astrocytoma, Low Grade Who Grade Ii Astrocytoma Fibrillary Astrocytoma Gemistocytic Astrocytoma Low-Grade Diffuse Astrocytoma Protoplasmic Astrocytoma
Cellular Ependymoma	Ependymoma Classic Ependymoma Papillary Ependymoma Tanycytic Ependymoma Clear Cell Ependymoma Ependymoma, Familial Epithelial Ependymoma Who Grade Ii Ependymal Neoplasm
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-13668	Lomeguatrib	Inhibitor	99.77%	Phase 2

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13057	O6BTG-octylglucoside	Inhibitor	95.0%	Unkown
HY-175299	Hedgehog IN-11	Inhibitor	/	Unkown
HY-186228	Anticancer agent 333		/	Unkown
HY-180540	MGMT-IN-1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	MGMT	VGNC	VGNC:43213
Rattus norvegicus	MGMT	RGD	RGD:3087
Bos taurus	MGMT	VGNC	VGNC:107299
Macaca mulatta	MGMT	VGNC	VGNC:74717
Mus musculus	MGMT	MGD	MGI:96977
Others	MGMT	NCBI